Patents by Inventor Jan-I Tu

Jan-I Tu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiohalogenation of proteins using trihalophenyl derivatives
    Patent number: 5569446
    Abstract: Compounds, useful as radiolabeling reagents, including a trihalogenated phenyl ring and having the formula ##STR1## wherein X.sub.1, X.sub.2 and X.sub.3 are halogens, one of which may be a radiohalogen, are disclosed. The invention further includes radiohalogenated proteins as well as processes for preparing such reagents and radiohalogenated proteins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 29, 1996
    Assignee: Bracco International B.V.
    Inventors: Marc Ogan, Frank P. Tomasella, Jan-I Tu
  • 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents
    Patent number: 5463080
    Abstract: Compounds, useful as radiolabeling reagents, including a trihalogenated phenyl ring and having the formula ##STR1## wherein X.sub.1, X.sub.2 and X.sub.3 are halogens, one of which may be a radiohalogen, are disclosed. The invention further includes radiohalogenated proteins as well as processes for preparing such reagents and radiohalogenated proteins.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: October 31, 1995
    Assignee: Bracco International B.V.
    Inventors: Marc Ogan, Frank P. Tomasella, Jan-I Tu
  • Monoclonal antibodies which bind (E)-5- (2-bromovinyl)-arabinofuranosyluracil and diagnostic methods based thereon
    Patent number: 5352584
    Abstract: Monoclonal antibodies which bind (E)-5-(2-bromovinyl)-arabinofuranosyluracil and/or immunologically related compounds, hybrid cell lines which produce these monoclonal antibodies, and immunoassay methods for detecting (E)-5-(2-bromovinyl)-arabinofuranosyluracil and/or immunologically related compounds using these monoclonal antibodies.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: October 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward M. Croze, Jan-I Tu, Marc D. Ogan
  • Derivatives of pravastatin and method of making the same
    Patent number: 5155229
    Abstract: Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.
    Type: Grant
    Filed: July 1, 1991
    Date of Patent: October 13, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard A. DiPietro, Jan-I Tu, Noor Z. Turabi
  • Monoclonal antibodies which bind thromboxane A2 receptor antagonists and diagnostic methods based thereon
    Patent number: 5141865
    Abstract: Monoclonal antibodies which bind thromboxane A2 receptor antagonists, hybrid cell lines which produce these monoclonal antibodies, and immunoassay methods for detecting thromboxane A2 receptor antagonists using these monoclonal antibodies.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: August 25, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward M. Croze, Jan-I Tu
  • Derivatives of pravastatin for inhibiting cholesterol biosynthesis
    Patent number: 5047549
    Abstract: Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.
    Type: Grant
    Filed: April 17, 1989
    Date of Patent: September 10, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard A. DiPietro, Jan-I Tu, Noor Z. Turabi
  • Derivatives of pravastatin for inhibiting cholesterol biosynthesis
    Patent number: 4857522
    Abstract: Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: August 15, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard A. DiPietro, Jan-I Tu, Noor Z. Turabi
  • Solid phase separation technique for use in radioimmunoassays
    Patent number: 4166844
    Abstract: A radioimmunoassay procedure, and article of manufacture for carrying out that procedure, are disclosed herein. The solid phase separation technique utilized in the radioimmunoassay of this invention utilizes a test tube, the internal surface of which has been coated with two antibody layers.
    Type: Grant
    Filed: April 18, 1977
    Date of Patent: September 4, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Jan-I Tu