Patents by Inventor Jan Izdebski

Jan Izdebski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of human growth hormone-releasing hormone, their preparation and use
    Patent number: 7928063
    Abstract: Growth hormone-releasing hormone analogs having the amino acid sequence of the formula: Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr10-R11-R12-VAL-Leu-Ala-Gln-Leu-Ser-Ala-R20-R21-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R29-NH2 (I), wherein R11 is hArg, Gab or Gap; R12 is hArg, Orn, Gab or Gap; R20 is hArg, hArg, Gab or Gap; R21 is hArg, Orn, Gab or Gap; R29 is D-Arg, hArg, Gab or Gap; and their pharmaceutically acceptable salts. Said peptides are potent and selective stimulators of GH release and they are highly resistant to enzymatic degradation.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: April 19, 2011
    Assignees: Instytut Farmaceutyczny, Zaklady Farmaceutyczne Polpharma
    Inventors: Jan Izdebski, Danuta Kunce, Alicja Orlowska, Ewa Witkowska, Wieslaw Szelejewski, Andrzej Kutner, Krzysztof Bankowski, Elzbieta Frackiewicz
  • Analogs of human growth hormone-releasing hormone, their preparation and use
    Publication number: 20060172927
    Abstract: Growth hormone-releasing hormone analogs having the amino acid sequence of the formula: Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr10-R11-R12-VAL-Leu-Ala-Gln-Leu-Ser-Ala-R20-R2-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R29-NH2 (I), wherein R11 is hArg, Gab or Gap; R12 is hArg, Orn, Gab or Gap; R20 is hArg, hArg, Gab or Gap; R21 is hArg, Orn, Gab or Gap; R29 is D-Arg, hArg, Gab or Gap; and their pharmaceutically acceptable salts. Said peptides are potent and selective stimulators of GH release and they are highly resistant to enzymatic degradation.
    Type: Application
    Filed: October 30, 2002
    Publication date: August 3, 2006
    Inventors: Jan Izdebski, Danuta Kunce, Alicja Orlowska, Ewa Witkowska, Wieslaw Szelejewski, Andrzej Kutner, Krzysztof Bankowski, Elzbieta Frackiewicz
  • Highly potent agonists of growth hormone releasing hormone
    Patent number: 5792747
    Abstract: Synthetic peptides which have the sequence:Q.sup.1 -CO -Ala.sup.2 -Asp.sup.3 -Ala.sup.4 -Ile.sup.5 -Phe.sup.6 -Thr.sup.7 -R.sup.8 -Ser.sup.9 -Tyr.sup.10 -Arg.sup.11 -R.sup.12 -Val.sup.13 -Leu.sup.14 -R.sup.15 -Gln.sup.16 -Leu.sup.17 -Ser.sup.18 -Ala.sup.19 -Arg.sup.20 -R.sup.21 -Leu.sup.22 -Leu.sup.23 -Gln.sup.24 -Asp.sup.25 -Ile.sup.26 -R.sup.27 -R.sup.28 -NH-Q.sup.2wherein Q.sup.1 is an omega or alpha-omega substituted alkyl of the structure: ##STR1## where: ?.phi.! is phenyl; Y is H, --NH.sub.2, CH.sub.3 CONH--or CH.sub.3 NH--; Z is H or CH.sub.3 ; m is 1 or 2; n is 0, 1 or 2; R.sup.8 is Asn, Ser, Gln or Thr; R.sup.12 is Lys or Orn; R.sup.15 is Gly, Ala, or Abu;R.sup.21 is Lys or Orn; R.sup.27 is Met or Nle; R.sup.28 is Ser or Asp; and Q.sup.2 is a lower omega-guanidino-alkyl group having a formula: --(CH.sub.2).sub.p --NH--C(NH.sub.2).dbd.NH wherein p is 2-6, and the pharmaceutically acceptable addition salts thereof with the pharmaceutically acceptable organic or inorganic bases or acids.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: August 11, 1998
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: Andrew V. Schally, Jan Izdebski