Patents by Inventor Jan KOCI

Jan KOCI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for production of 2-chloro-4-nitroimidazole derivatives
    Patent number: 11104650
    Abstract: An improved process for preparing 2-chloro-4-nitroimidazole derivatives which are useful intermediates in the preparation of an anti-tuberculosis drug is provided. The process may comprise the step of chlorinating nitroimidazoles with a chlorinating agent and an activating agent to give 2-chloro-4-nitroimidazole derivatives.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: August 31, 2021
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Petr Novak, Petr Zahradnik, Jiri Tauchman, Jan Koci, Antonin Sturc
  • Method of 4-boronophenylalanine production
    Patent number: 11098067
    Abstract: The present invention relates to a method of production of 4-boronophenylalanine (BPA) from 4-iodophenylalanine, in which all the functional groups of the amino acid are protected by benzyl protection method, and which uses isopropyl magnesium halogenide stabilized by a complexation base, and subsequent condensation of the resulting Grignard reagent with a boric acid ester. The final reaction step, catalytic hydrogenolysis or transfer hydrogenolysis of protecting groups on the amino acid, occurs after hydrolysis of the boronate ester groups.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: August 24, 2021
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Petr Zahradnik, Antonin Sturc, Jiri Malinak, Jan Koci
  • PROCESS FOR PRODUCTION OF 2-CHLORO-4-NITROIMIDAZOLE DERIVATIVES
    Publication number: 20210053925
    Abstract: An improved process for preparing 2-chloro-4-nitroimidazole derivatives which are useful intermediates in the preparation of an anti-tuberculosis drug is provided. The process may comprise the step of chlorinating nitroimidazoles with a chlorinating agent and an activating agent to give 2-chloro-4-nitroimidazole derivatives.
    Type: Application
    Filed: January 29, 2018
    Publication date: February 25, 2021
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Petr NOVAK, Petr ZAHRADNIK, Jiri TAUCHMAN, Jan KOCI, Antonin STURC
  • METHOD OF 4-BORONOPHENYLALANINE PRODUCTION
    Publication number: 20200392163
    Abstract: The present invention relates to a method of production of 4-boronophenylalanine (BPA) from 4-iodophenylalanine, in which all the functional groups of the amino acid are protected by benzyl protection method, and which uses isopropyl magnesium halogenide stabilized by a complexation base, and subsequent condensation of the resulting Grignard reagent with a boric acid ester. The final reaction step, catalytic hydrogenolysis or transfer hydrogenolysis of protecting groups on the amino acid, occurs after hydrolysis of the boronate ester groups.
    Type: Application
    Filed: February 19, 2019
    Publication date: December 17, 2020
    Inventors: Petr ZAHRADNIK, Antonin STURC, Jiri MALINAK, Jan KOCI
  • Lighting domes with reflective gradient and broad spectrum light source
    Patent number: 9933372
    Abstract: A lighting dome that can be used to inspect semiconductor wafers can include a small aperture, backlighting, a reflectance gradient and/or a broad spectrum light source.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 3, 2018
    Assignee: Graftek Imaging, Inc.
    Inventors: Romik Chatterjee, Robert Martin Eastlund, Christopher Jan Koci, Archer Forrest Finley
  • LIGHTING DOMES
    Publication number: 20160025651
    Abstract: A lighting dome that can be used to inspect semiconductor wafers can include a small aperture, backlighting, a reflectance gradient and/or a broad spectrum light source.
    Type: Application
    Filed: October 7, 2015
    Publication date: January 28, 2016
    Applicant: GRAFTEK IMAGING INC.
    Inventors: Romik Chatterjee, Robert Martin Eastlund, Christopher Jan Koci, Archer Forrest Finley
  • Lighting domes with pin hole lens
    Patent number: 9157867
    Abstract: A lighting dome that can be used to inspect semiconductor wafers includes a small aperture, and can include backlighting, a reflectance gradient and/or a broad spectrum light source. A pin hole lens is aligned with the small aperture.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 13, 2015
    Assignee: GRAFTEK IMAGING INC.
    Inventors: Romik Chatterjee, Robert Martin Eastlund, Christopher Jan Koci, Archer Forrest Finley
  • Lighting Domes
    Publication number: 20140263981
    Abstract: A lighting dome that can be used to inspect semiconductor wafers can include a small aperture, backlighting, a reflectance gradient and/or a broad spectrum light source.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventors: Romik Chatterjee, Robert Martin Eastlund, Christopher Jan Koci, Archer Forrest Finley