Abstract: A bone biopsy needle assembly which includes a handle having a proximal concave curved surface having an off-center radius producing a first relatively narrow end and a second relatively wide end of the handle. The wide end is curved to conform to the shape of a user's palm, and the narrow end forms a surface to limit lateral slippage in the direction of the user's forefinger. The handle also has a distal surface with a receiving opening. A cannula has a central lumen, with a first end extending into the receiving opening and being connected to the distal surface of the handle toward the relatively narrow end and having a second end extending distally from the handle. A removable stylet is slidably received within the lumen and has a proximal knob carried by the handle.