Patents by Inventor Jan Lötvall
Jan Lötvall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220387505Abstract: The present disclosure provides ghost nanovesicles (gNVs) that are deficient in cytosolic components. Methods of making such vesicles and therapeutic uses of such vesicles are also provided. The gNVs may be used in preventing or treating conditions that may benefit from administration of the gNVs. Such conditions include conditions that involve inflammation.Type: ApplicationFiled: September 11, 2020Publication date: December 8, 2022Inventors: Jan Lötvall, Kyong-su Park
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Publication number: 20220334120Abstract: The present disclosure relates to a method of isolating extracellular vesicles directly from human tissues. The invention further relates to a method of identifying disease and tissue specific membrane proteins on extracellular vesicles by membrane isolation and proteomic analysis. The invention further relates to methods of diagnosing diseases by capturing extracellular vesicles by the use of disease specific membrane proteins from body fluids, and detecting or analyzing molecular signatures (proteome, DNA, and RNA) on captured extracellular vesicles. Moreover, the present invention relates to kits, apparatus and software required for implementing aforementioned methods.Type: ApplicationFiled: April 28, 2022Publication date: October 20, 2022Inventors: Jan Lötvall, Su Chul Jang, Rossella Crescitelli
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Publication number: 20220080035Abstract: Non-naturally occurring vesicles derived from bacteria, e.g., pathogenic bacteria, methods for making the vesicles, and methods for using compositions of these vesicles are disclosed. Methods of using the vesicles include prevention and/or treatment of bacterial infections. Also provided herein are compositions that include vesicles derived front bacteria and tumor vesicles, methods for making the tumor vesicles, and methods for using the compositions of bacterial vesicles and tumor vesicles. Methods of using the compositions of bacterial vesicles and tumor vesicles include treatment of cancer in a subject. Tumor vesicles may be derived from cancer cells present in the subject to be treated or from a cancer cell line expressing at least one neoantigen. The neoantigen may be specific to the subject and may have been identified by sequencing of the cancer cells from the subject. The neoantigen may be a neoantigen known to be commonly expressed in a particular type of cancer.Type: ApplicationFiled: January 7, 2020Publication date: March 17, 2022Inventors: Kyong-su PARK, Rossella CRESCITELLI, Jan LÖTVALL
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Publication number: 20210000976Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: ApplicationFiled: June 18, 2020Publication date: January 7, 2021Applicant: Codiak BioSciences, Inc.Inventors: Jan LÖTVALL, Hadi VALADI
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Patent number: 10695443Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: GrantFiled: November 27, 2018Date of Patent: June 30, 2020Assignee: Codiak BioSciences, Inc.Inventors: Jan Lötvall, Hadi Valadi
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Publication number: 20200063138Abstract: A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a DNA sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said inhibitor oligonucleotide from said cell. Nanovesicles produced by the claimed method can be effectively and specifically targeted to e.g. cancer cells to deliver the inhibitor oligonucleotide.Type: ApplicationFiled: August 2, 2019Publication date: February 27, 2020Applicant: Codiak BioSciences, Inc.Inventors: Jan LÖTVALL, Jonas Andrej NILSSON
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Patent number: 10370663Abstract: A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a DNA sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said inhibitor oligonucleotide from said cell. Nanovesicles produced by the claimed method can be effectively and specifically targeted to e.g. cancer cells to deliver the inhibitor oligonucleotide.Type: GrantFiled: November 28, 2017Date of Patent: August 6, 2019Assignee: Codiak BioSciences, Inc.Inventors: Jan Lötvall, Jonas Andrej Nilsson
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Publication number: 20190111155Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: ApplicationFiled: November 27, 2018Publication date: April 18, 2019Inventors: Jan LÖTVALL, Hadi VALADI
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Publication number: 20180236104Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: ApplicationFiled: December 28, 2017Publication date: August 23, 2018Inventors: Jan LÖTVALL, Hadi VALADI
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Publication number: 20180135056Abstract: A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a DNA sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said inhibitor oligonucleotide from said cell. Nanovesicles produced by the claimed method can be effectively and specifically targeted to e.g. cancer cells to deliver the inhibitor oligonucleotide.Type: ApplicationFiled: November 28, 2017Publication date: May 17, 2018Inventors: Jan LÖTVALL, Jonas Andrej NILSSON
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Patent number: 9889210Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: GrantFiled: March 31, 2017Date of Patent: February 13, 2018Assignee: Codiak BioSciences, Inc.Inventors: Jan Lötvall, Hadi Valadi
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Patent number: 9856477Abstract: A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a DNA sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said inhibitor oligonucleotide from said cell. Nanovesicles produced by the claimed method can be effectively and specifically targeted to e.g. cancer cells to deliver the inhibitor oligonucleotide.Type: GrantFiled: November 13, 2013Date of Patent: January 2, 2018Assignee: Codiak BioSciences, Inc.Inventors: Jan Lötvall, Jonas Andrej Nilsson
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Publication number: 20170258938Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: ApplicationFiled: March 31, 2017Publication date: September 14, 2017Inventors: Jan LÖTVALL, Hadi VALADI
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Patent number: 9629929Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: GrantFiled: June 25, 2015Date of Patent: April 25, 2017Assignee: CODIAK BIOSCIENCES, INC.Inventors: Jan Lötvall, Hadi Valadi
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Publication number: 20160168572Abstract: A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a DNA sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said inhibitor oligonucleotide from said cell. Nanovesicles produced by the claimed method can be effectively and specifically targeted to e.g. cancer cells to deliver the inhibitor oligonucleotide.Type: ApplicationFiled: November 13, 2013Publication date: June 16, 2016Inventors: Jan LÖTVALL, Jonas Andrej NILSSON
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Publication number: 20150290343Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: ApplicationFiled: June 25, 2015Publication date: October 15, 2015Inventors: Jan LÖTVALL, Hadi VALADI
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Patent number: 9085778Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.Type: GrantFiled: April 30, 2007Date of Patent: July 21, 2015Assignee: VL27, Inc.Inventors: Jan Lötvall, Hadi Valadi