Patents by Inventor Jan Lehmbeck
Jan Lehmbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220089978Abstract: The present invention concerns a detergent and a pharmaceutical composition comprising a deoxyribonuclease (DNase), wherein the DNase is obtained from a fungal source. It further concerns a laundering method and the use of DNase. The present invention further relates to polypeptides having DNase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.Type: ApplicationFiled: December 7, 2021Publication date: March 24, 2022Applicant: Novozymes A/SInventors: Klaus GORI, Marie ALLESEN-HOLM, Lilian Eva Tang BALTSEN, Allan NOERGAARD, Jan LEHMBECK
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Patent number: 11214760Abstract: The present invention concerns a detergent and a pharmaceutical composition comprising a deoxyribonuclease (DNase), wherein the DNase is obtained from a fungal source. It further concerns a laundering method and the use of DNase. The present invention further relates to polypeptides having DNase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.Type: GrantFiled: October 9, 2018Date of Patent: January 4, 2022Assignee: NOVOZYMES A/SInventors: Klaus Gori, Marie Allesen-Holm, Lilian Eva Tang Baltsen, Allan Noergaard, Jan Lehmbeck
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Publication number: 20210253982Abstract: The present invention concerns the use of a polypeptide having DNase activity for preventing, reducing or removing a biofilm from an item, wherein the item is a hard surface, a composition comprising such polypeptide and a method for cleaning.Type: ApplicationFiled: April 5, 2021Publication date: August 19, 2021Applicant: Novozymes A/SInventors: Klaus Gori, Lillian Eva Tang Baltsen, Marie Allesen-Holm, Allan Noergaard, Jan Lehmbeck, Kirk Matthew Schnorr
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Publication number: 20200248106Abstract: The present invention concerns a detergent and a pharmaceutical composition comprising a deoxyribonuclease (DNase), wherein the DNase is obtained from a fungal source. It further concerns a laundering method and the use of DNase. The present invention further relates to polypeptides having DNase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.Type: ApplicationFiled: October 9, 2018Publication date: August 6, 2020Applicant: NOVOZYMES A/SInventors: Klaus GORI, Marie ALLESEN-HOLM, Lilian Eva Tang BALTSEN, Allan NOERGAARD, Jan LEHMBECK
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Patent number: 10619144Abstract: The present invention relates to a recombinant fungal host cell comprising at least one first polynucleotide encoding a polypeptide of interest; and one or more second polynucleotide encoding a fungal PepC protease, wherein the one or more second polynucleotide is operably linked to a regulated heterologous promoter, as well as a method for producing a polypeptide of interest, comprising cultivating said fungal host cell.Type: GrantFiled: August 22, 2014Date of Patent: April 14, 2020Assignee: Novozymes A/SInventors: Hiroshi Teramoto, Hiroaki Udagawa, Jan Lehmbeck, Michael Lynge Nielsen
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Patent number: 10131863Abstract: The present invention concerns a detergent and a pharmaceutical composition comprising a deoxyribonuclease (DNase), wherein the DNase is obtained from a fungal source. It further concerns a laundering method and the use of DNase. The present invention further relates to polypeptides having DNase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.Type: GrantFiled: April 10, 2015Date of Patent: November 20, 2018Assignee: NOVOZYMES A/SInventors: Klaus Gori, Marie Allesen-Holm, Lillian Eva Tang Baltsen, Allan Noergaard, Jan Lehmbeck
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Publication number: 20170107457Abstract: The present invention concerns a detergent and a pharmaceutical composition comprising a deoxyribonuclease (DNase), wherein the DNase is obtained from a fungal source. It further concerns a laundering method and the use of DNase. The present invention further relates to polypeptides having DNase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.Type: ApplicationFiled: April 10, 2015Publication date: April 20, 2017Applicant: NOVOZYMES A/SInventors: Klaus GORI, Marie ALLESEN-HOLM, Lillian Eva Tang BALTSEN, Allan NOERGAARD, Jan LEHMBECK
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Publication number: 20170044468Abstract: The present invention concerns the use of a polypeptide having DNase activity for preventing, reducing or removing a biofilm from an item, wherein the item is a hard surface, a composition comprising such polypeptide and a method for cleaning.Type: ApplicationFiled: April 30, 2015Publication date: February 16, 2017Applicant: Novozymes A/SInventors: Klaus Gori, Lillian Eva Tang Baltsen, Marie Allesen-Holm, Allan Noergaard, Jan Lehmbeck, Kirk Matthew Schnorr
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Publication number: 20160244737Abstract: The present invention relates to a recombinant fungal host cell comprising at least one first polynucleotide encoding a polypeptide of interest; and one or more second polynucleotide encoding a fungal PepC protease, wherein the one or more second polynucleotide is operably linked to a regulated heterologous promoter, as well as a method for producing a polypeptide of interest, comprising cultivating said fungal host cell.Type: ApplicationFiled: August 22, 2014Publication date: August 25, 2016Inventors: Hiroshi Teramoto, Hiroaki Udagawa, Jan Lehmbeck, Michael Lynge Nielsen
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Patent number: 8633010Abstract: The present invention relates to an isolated polypeptide having PepC inhibitory activity as well as to a method for producing a heterologous polypeptide of interest in an Aspergillus host cell comprising: (a) cultivating the Aspergillus host cell comprising a first and a second nucleic acid sequences under conditions conducive for the expression of the polypeptides encoded by the said first and second nucleic acid sequences, and wherein the first nucleic acid sequence encodes a heterologous polypeptide of interest and the second nucleic acid encodes the inhibitor polypeptide of the invention, and wherein the inhibitor polypeptide is expressed from a recombinant nucleic acid construct resulting in an increased level of the inhibitor polypeptide compared to an Aspergillus host cell not comprising the recombinant nucleic acid construct; and (b) recovering the heterologous polypeptide.Type: GrantFiled: December 2, 2008Date of Patent: January 21, 2014Assignee: Novozymes A/SInventors: Jan Lehmbeck, Hiroaki Udagawa
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Patent number: 7858360Abstract: The disclosure relates to a filamentous fungal cell in which an endogenous alkaline protease activity, an endogenous neutral metalloprotease activity, an endogenous serine protease activity, and an endogenous kexin maturase activity have been completely or partially inactivated. Particularly the endogenous alkaline protease activity, the endogenous.neutral metalloprotease activity, the endogenous serine protease activity, and the kexin maturase activity are encoded by the alp, npI, pepC and kexB genes respectively. The filamentous fungal cell is particularly suitable for production of heterologous proteins such as antibodies.Type: GrantFiled: October 17, 2006Date of Patent: December 28, 2010Assignee: Novozymes A/SInventors: Mogens Trier Hansen, Christian Isak Jorgensen, Jan Lehmbeck
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Publication number: 20100273980Abstract: The present invention relates to an isolated polypeptide having PepC inhibitory activity as well as to a method for producing a heterologous polypeptide of interest in an Aspergillus host cell comprising: (a) cultivating the Aspergillus host cell comprising a first and a second nucleic acid sequences under conditions conducive for the expression of the polypeptides encoded by the said first and second nucleic acid sequences, and wherein the first nucleic acid sequence encodes a heterologous polypeptide of interest and the second nucleic acid encodes the inhibitor polypeptide of the invention, and wherein the inhibitor polypeptide is expressed from a recombinant nucleic acid construct resulting in an increased level of the inhibitor polypeptide compared to an Aspergillus host cell not comprising the recombinant nucleic acid construct; and (b) recovering the heterologous polypeptide.Type: ApplicationFiled: December 2, 2008Publication date: October 28, 2010Applicant: NOVOZYMES A/SInventors: Jan Lehmbeck, Hiroaki Udagawa
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Publication number: 20100062491Abstract: The present invention relates to a method for increasing the production yield of a secreted antibody or antibody fragment in a filamentous fungal host cell, comprising: recombinant expression of the antibody or antibody fragment and over-expressing a BiP chaperone protein.Type: ApplicationFiled: January 3, 2008Publication date: March 11, 2010Applicant: Novozymes A/SInventor: Jan Lehmbeck
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Publication number: 20080248530Abstract: The present invention relates to a filamentous fungal cell in which an endogenous alkaline protease activity, an endogenous neutral metalloprotease activity and an endogenous serine protease activity of the subtilisin type have been completely or partially inactivated. Particularly the endogenous alkaline protease activity, the endogenous neutral metalloprotease activity and the endogenous serine protease activity of the subtilisin type are encoded by the alp, npI and pepC genes respectively. The filamentous fungal cell is particularly suitable for production of heterologous proteins such as antibodies.Type: ApplicationFiled: October 17, 2006Publication date: October 9, 2008Applicant: Novozymes AVSInventors: Mogens Trier Hansen, Christian Isak Jorgensen, Jan Lehmbeck
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Patent number: 7241614Abstract: The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes responsible for the biosynthesis or secretion of at least one toxin, and (ii) the mutant produces less of the toxin than the parent Aspergillus cell when cultured under the same conditions; and (b) isolating the polypeptide from the culture medium. Also, mutants of Aspergillus cells are provided, as well as methods for obtaining the mutant cells.Type: GrantFiled: October 26, 2004Date of Patent: July 10, 2007Assignee: Novozymes A/SInventors: Bjorn Eggert Christensen, Henrik Mollgaard, Svend Kaasgaard, Jan Lehmbeck
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Publication number: 20070118930Abstract: The present invention relates to polypeptides having cellobiase activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.Type: ApplicationFiled: September 28, 2006Publication date: May 24, 2007Applicant: Novozymes A/SInventors: Martin Schulein, Jan Lehmbeck, Torben Henriksen
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Publication number: 20060240521Abstract: The invention relates to a DNA sequences for regulating transcription of a structural gene encoding a polypeptide in a eukaryotic host cell comprising (a) a first DNA sequence to which RNA polymerase binds which DNA sequence comprises a mRNA initiation site; and further (b) one or more DNA sequence(s) to which RNA polymerase binds with or without a mRNA initiation site. The invention also relates to a DNA construct and an expression vector and a host cell comprising the DNA sequence of the invention.Type: ApplicationFiled: May 19, 2006Publication date: October 26, 2006Applicant: Novozymes A/SInventor: Jan Lehmbeck
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Patent number: 7063962Abstract: The invention relates to a DNA sequences for regulating transcription of a structural gene encoding a polypeptide in a eukaryotic host cell comprising (a) a first DNA sequence to which RNA polymerase binds which DNA sequence comprises a mRNA initiation site; and further (b) one or more DNA sequence(s) to which RNA polymerase binds with or without a mRNA initiation site. The invention also relates to a DNA construct and an expression vector and a host cell comprising the DNA sequence of the invention.Type: GrantFiled: July 12, 2002Date of Patent: June 20, 2006Assignee: Novozymes A/SInventor: Jan Lehmbeck
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Patent number: 7060468Abstract: The invention relates to starch conversion processes using glucoamylases derived from Talaromyces emersonii and related glucoamylases.Type: GrantFiled: July 22, 2003Date of Patent: June 13, 2006Assignee: Novozymes A/SInventors: Bjarne Ronfeldt Nielsen, Ruby Ilum Nielsen, Jan Lehmbeck
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Publication number: 20060075519Abstract: The present invention relates to polypeptides having cellobiase activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.Type: ApplicationFiled: May 17, 2002Publication date: April 6, 2006Applicant: Novozymes A/SInventors: Martin Schulein, Torben Henriksen, Jan Lehmbeck