Abstract: An apparatus consisting of stacked slab waveguides whose outputs are vertically staggered is disclosed. At the input to the stacked waveguides, the entrances to each slab lie in approximately the same vertical plane. A spot which is imaged onto the input will be transformed approximately to a set of staggered rectangles at the output, without substantial loss in brightness, which staggered rectangles can serve as a convenient input to a spectroscopic apparatus. A slit mask can be added to spatially filter the outputs so as to present the desired transverse width in the plane of the spectroscopic apparatus parallel to its dispersion.

Abstract: An apparatus is disclosed wherein laser radiation illuminates a sample using all reflective optics and wherein in-elastically scattered light from the sample is collected using the identical elements. The apparatus obviates the problem of contaminating the laser radiation with unwanted spectra from transmissive optics while providing very high rejection of the laser radiation with respect to the in-elastically scattered light. In addition, the apparatus can collect and launch light with high numerical aperture and large field of view.

Abstract: An apparatus is presented for stabilizing an optical, thermal, and mechanical interface between a spectroscopic and/or imaging system and a biological sample. The apparatus includes a window retainer having a retainer surface and a well. The retainer surface surrounds the well. Further, the retainer surface is substantially planar. An optical window is located in the well. The optical window comprises a first and second surface. The second surface is in contact with the window retainer. The first surface is substantially flush with the retainer surface. The apparatus further includes an attachment mechanism coupling the window retainer to the biological sample such that a fluid, gel, adhesive or elastomer interposed between the optical window and the biological sample is trapped in the well.

Abstract: A means for optically coupling a semiconductor laser to an optical fiber is disclosed. In one embodiment, a volume phase holographic element is disposed on a light-emitting surface of a semiconductor laser. The volume phase holographic element acts as an aberration-corrector for a lens that is disposed between the semiconductor laser and the optical fiber. In this way, an inexpensive lens that is not aberration free can be used. In some embodiments, the volume phase holographic element converts a Gaussian light beam emitted by the semiconductor laser into an annular beam that is more suitable for long distance transmission in multimode fibers.

Abstract: The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.

Abstract: An apparatus comprising an optical window transmits both an excitation beam to a sample and scattered light from the sample which is within the angular range of the collection optics. Scattered light from the sample outside the angular range of the collection optics is re-directed back to the sample by reflection from one or more surfaces of the apparatus. As a result, the magnitude of scattered light collected is increased.

Abstract: An apparatus is presented in which a sample can be accurately repositioned in a spectroscopic and/or imaging apparatus upon multiple insertions, and where the apparatus can be worn by living subjects for extended periods of time. The apparatus additionally reduces the temperature increase and stabilizes the temperature of the sample upon irradiation with an optical source of excitation. Additionally, the apparatus stabilizes the pressure and critical optical properties of the sample and its interface with the apparatus. Alternatively or additionally, the apparatus can be used to alter and/or substantially reduce fluorescence from targeted fluorophores in the sample.

Abstract: The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.

Abstract: The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.

Abstract: An apparatus for increasing the blood perfusion in skin by elevating the temperature, and for providing superior heat sinking to the skin of thermally dissipative devices is disclosed. The increased perfusion gives rise to improved thermal transport properties near the site of elevated temperature which is advantageously used by thermally connecting the dissipative devices to the skin. The heat generated by the thermally dissipative devices can supplement or replace separate heating elements to elevate the skin temperature. Alternatively, thermal isolation of the heated area of the skin from the heat sinks of the dissipative devices can minimize the temperature of the skin in contact with the heat sinks.

Abstract: An apparatus is disclosed wherein laser radiation illuminates a sample using all reflective optics and wherein in-elastically scattered light from the sample is collected using the identical elements. The apparatus obviates the problem of contaminating the laser radiation with unwanted spectra from transmissive optics while providing very high rejection of the laser radiation with respect to the in-elastically scattered light. In addition, the apparatus can collect and launch light with high numerical aperture and large field of view.

Abstract: An apparatus for enhancing the selectivity for spectroscopic measurements of analytes in a turbid medium is described. In one example, spatial filters are used to select only certain radii from the medium to be imaged. This selection is accomplished by placing an optical obstruction on the surface of the medium or at an image plane of the surface later in the optical imaging system. In one implementation, this is achieved by placing a fiber bundle at an image plane of the collecting optical system and then using a spacer of appropriate size at the center of the fiber bundle to act as a central obstruction.

Abstract: Vertical cavity surface emitting lasers are disclosed, one example of which includes a substrate upon which a lower mirror layer is formed. An active region and upper mirror layer are disposed, in that order, on the lower mirror layer. In particular, the upper mirror layer includes a plurality of DBR layers formed on the active region. The upper mirror layer additionally includes a photonic crystal formed on the plurality of DBR layers and having a periodic structure that contributes to the definition of a central defect. As a consequence of this structure, the photonic crystal has a reflectivity that is wavelength dependent, and the central defect enables the VCSEL to propagate a single mode.

Abstract: Vertical cavity surface emitting lasers are disclosed, one example of which includes a substrate upon which a lower mirror layer is formed. An active region and upper mirror layer are disposed, in that order, on the lower mirror layer. In particular, the upper mirror layer includes a plurality of DBR layers formed on the active region. The upper mirror layer additionally includes a photonic crystal formed on the plurality of DBR layers and having a periodic structure that contributes to the definition of a central defect. As a consequence of this structure, the photonic crystal has a reflectivity that is wavelength dependent, and the central defect enables the VCSEL to propagate a single mode.

Abstract: Methods are disclosed for producing a tunable vertical cavity surface emitting laser (VCSEL) using photonic crystals and an electrostrictive material that includes a hologram with a narrow filter function. Photonic crystals are formed such that the active region of the VCSEL is bounded by the photonic crystals. The photonic crystals have a periodic cavity structure that reflects light of certain wavelengths through the active region of the VCSEL such that laser light at the wavelengths is generated. The periodic cavity structure includes a central defect that does not include any cavities. The single mode is emitted through the central defect. The electrostrictive material that includes a hologram makes the VCSEL tunable because the shape of the electrostrictive material changes when an electric field is applied. The filter function of the hologram thus changes as well in response to the electric field such that the VCSEL is tunable.

Abstract: A method of reducing interference in a data stream includes filtering the data stream using a first equalizer to output a first filtered data stream. Also, the data stream is filtered using a second equalizer to create a second filtered data stream. Then, one or more error rates based on the first filtered data stream and the second filtered data stream are determined. Based at least in part on those error rates, a filtered data stream is selected from among the first filtered data stream and the second filtered data stream. A threshold value is determined, and then compared against the selected filtered data stream to generate a data bit.

Abstract: A method is proposed whereby photo-bleaching is used not only to change the absorption and fluorescence of a sample but is also employed to change its scattering characteristics. When the compounds which are bleached are contained in regions wherein the real part of the index of refraction is greater than or equal to the average index of the medium, the bleaching will result in reduction in the scattering at wavelengths longer than the wavelength of the bleaching source. This reduction can be useful in measuring the concentration of analytes located at significant depths within turbid media.

Abstract: The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.

Abstract: An apparatus is presented in which a sample can be accurately repositioned in a spectroscopic and/or imaging apparatus upon multiple insertions, and where the apparatus can be worn by living subjects for extended periods of time. The apparatus additionally reduces the temperature increase and stabilizes the temperature of the sample upon irradiation with an optical source of excitation. Additionally, the apparatus stabilizes the pressure and critical optical properties of the sample and its interface with the apparatus. Alternatively or additionally, the apparatus can be used to alter and/or substantially reduce fluorescence from targeted fluorophores in the sample.

Abstract: This disclosure concerns systems, methods and devices for temperature-based control of laser performance. One example of a method is performed in connection with a laser of an optoelectronic transceiver. In particular, the laser is operated over a range of temperatures and the optical output of the laser is monitored. During operation of the laser, the bias current and current swing supplied to the laser are adjusted to the extent necessary to maintain a substantially constant optical output from the laser over the range of temperatures.