Patents by Inventor Jan Lonzaric

Jan Lonzaric has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210324413
    Abstract: Genetic circuits have been developed to regulate behaviors of replicon RNA in responses to small molecules, which has broader applications, such as for quantitative expression of cargo genes, temporary expression of immunomodulatory cytokines or antigens for better cancer immunotherapy or vaccination, and for increased safety in use of self-replicating vectors or in combination with other viral-delivery vectors. Described herein are genetic circuits suitable for systems that either require a tight off state or a slow off state, which can serve for instance where either a kill switch or prolonged protein expression (e.g., of vaccine antigens) are needed.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Ron Weiss, Yingzhong Li, Jan Lonzaric, Parisa Yousefpour