Patents by Inventor Jan Lubiñski

Jan Lubiñski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FAST ASSIGNMENT OF ADEQUATE CHEMOTHERAPY WITH LATINUM BASED DRUGS FOR CANCER PATIENTS BASED ON THE IDENTIFICATION OF CONSTITUTIONAL BRCAL MUTATIONS
    Publication number: 20110245095
    Abstract: A new method to improve therapy outcome depending on a particular constitutional genotype have been disclosed. Subject of invention allows to synthesize DNA and identification of germline BRCA1 genetic abnormalities which are correlated with a significantly increased clinical response to chemotherapy based on platinum derived drugs in cancer patients.
    Type: Application
    Filed: July 6, 2009
    Publication date: October 6, 2011
    Inventors: Tomasz Byrski, Jacek Gronwald, Jan Lubinski
  • METHOD FOR DETERMINING REDUCED PREDISPOSITION TO CANCER BASED ON GENETIC PROFILE
    Publication number: 20110105342
    Abstract: The invention provide methods for early detection of a reduced risk of developing cancer, which comprises detecting the absence of a series of genetic polymorphisms associated with a predisposition of developing cancer, including the polymorphisms of the genes BRCA1, BRCA2, CARD15 (NOD2), CHEK2, CDKN2A (P16), CYP1B1, FGFR2 (KGFR2), MAP3K1 (MEKK1), p53 (TP53), TNRC9, XPD (ERCC2) and the genetic marker Rs6983267, in a biological sample from the analyzed subject, wherein the absence of the genetic polymorphisms is indicative of significantly decreased risk of developing, at least, breast cancer.
    Type: Application
    Filed: March 13, 2009
    Publication date: May 5, 2011
    Inventors: Jan Lubinski, Tadeusz Debniak, Grzegorz Kurzawski, Anna Jakubowska, Krzystof Medrek, Cezary Cybulski, Jacek Gronwald, Tomasz Huzarski, Bohdan Gorski, Tomasz Byrski, Joanna Matyjasik, Pablo Serrano Fernandez
  • Determining a predisposition to cancer
    Patent number: 7851162
    Abstract: The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: December 14, 2010
    Inventors: Jan Lubiñski, Janina Suchy, Grzegorz Kurzawski, Tadeusz Dêbniak, Cezary Cybulski
  • Determining a predisposition to cancer
    Patent number: 7745133
    Abstract: The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of a NBS1 gene.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: June 29, 2010
    Assignee: Pomeranian Academy of Medicine
    Inventors: Cezary Cybulski, Jan Lubinski, Bohdan Gorski, Bartlomiej Gliniewicz, Andrzej Sikorski, Tomasz Huzarski, Tadeusz Debniak, Jacek Gronwald, Tomasz Byrski
  • Determining a predisposition to cancer
    Publication number: 20090197255
    Abstract: The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of a NBS1 gene.
    Type: Application
    Filed: December 5, 2007
    Publication date: August 6, 2009
    Inventors: Cezary Cybulski, Jan Lubinski, Bohdan Gorski, Bartlomiej Gliniewicz, Andrzej Sikorski, Tomasz Huzarski, Tadeusz Debniak, Jacek Gronwald, Tomasz Byrski
  • Determining a predisposition to cancer
    Publication number: 20090092984
    Abstract: The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene.
    Type: Application
    Filed: July 28, 2008
    Publication date: April 9, 2009
    Inventors: Jan Lubinski, Janina Suchy, Grzegorz Kurzawski, Tadeusz Debniak, Cezary Cybulski
  • Method for improving neoadjuvant chemotherapy
    Publication number: 20080241834
    Abstract: Disclosed is a method and composition for optimizing the efficiency of breast cancer neoadjuvant chemotherapy, depending on the particular constitutional genotype characteristics of the gene BRCA1 in each patient. Generally, the invention concerns a new method to improve neoadjuvant therapy depending on a particular constitutional genotype. Subject of invention allow to synthesize DNA and identification of germline BRCA1 genetic abnormalities which are correlated with a significantly decreased clinical response to neoadjuvant chemotherapy based on taxane-derived cytostatics in breast cancer patients.
    Type: Application
    Filed: June 1, 2007
    Publication date: October 2, 2008
    Inventors: Tomasz Byrski, Jacek Gronwald, Jan Lubinski, Tomasz Huzarski, Steven Narod
  • Determining a predisposition to cancer
    Patent number: 7407755
    Abstract: The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: August 5, 2008
    Inventors: Jan Lubiñski, Janina Suchy, Grzegorz Kurzawski, Tadeusz Dêbniak, Cezary Cybulski
  • Determining a predisposition to cancer
    Patent number: 7319007
    Abstract: The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of a NBS1 gene.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: January 15, 2008
    Assignee: Pomeranian Academy of Medicine
    Inventors: Cezary Cybulski, Jan Lubinski, Bohdan Gorski, Bartlomiej Gliniewicz, Andrzej Sikorski, Tomasz Huzarski, Tadeusz Debniak, Jacek Gronwald, Tomasz Byrski
  • Methods, uses and compositions for determining redisposition to cancers by identifying specific genotypes of CYP1B1 gene
    Publication number: 20070009943
    Abstract: The present invention is provides the methods, uses and compositions useful in diagnosis of low-penetrance predisposition to human cancers of various sites wherein constitutional variants of alterations within CYP1B1 gene are analyzed in biological material from examined individual.
    Type: Application
    Filed: June 23, 2006
    Publication date: January 11, 2007
    Inventors: Jan Lubinski, Joanna Matyjasik
  • Determining a predisposition of cancer
    Publication number: 20050191669
    Abstract: The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene.
    Type: Application
    Filed: January 18, 2005
    Publication date: September 1, 2005
    Inventors: Jan Lubinski, Janina Suchy, Grzegorz Kurzawski, Tadeusz Debniak, Cezary Cybulski
  • Pharmaceutical compositions and methods for the prevention of breast and ovarian cancer
    Publication number: 20050069594
    Abstract: Disclosed is a method for the prevention of and the reduction of risk of breast cancer and ovarian cancer in a female human subject by the administration of selenium (or its salts or derivatives).
    Type: Application
    Filed: August 10, 2004
    Publication date: March 31, 2005
    Inventors: Jan Lubinski, Steven Narod, Elzbieta Kowalska, Bohdan Gorski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Jowita Huzarska, Barbara Gawronska-Szklarz
  • Determining a predisposition to cancer
    Publication number: 20050064461
    Abstract: The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of a NBS1 gene.
    Type: Application
    Filed: June 14, 2004
    Publication date: March 24, 2005
    Inventors: Cezary Cybulski, Jan Lubinski, Bohdan Gorski, Bartlomiej Gliniewicz, Andrzej Sikorski, Tomasz Huzarski, Tadeusz Debniak, Jacek Gronwald, Tomasz Byrski