Patents by Inventor Jan. M. Mikkelsen

Jan. M. Mikkelsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
    Patent number: 5623059
    Abstract: A process for the microbial production of a protein susceptible to inactivation in a fluid production medium by continuously and reversibly protecting said protein against said inactivation during the production stage, separating the protein from the production medium, deprotecting the protein, and recovering the protein product. The process is especially useful for obtaining substantially increased yields of the protein in question by continuously precipitating said protein.
    Type: Grant
    Filed: August 16, 1994
    Date of Patent: April 22, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Per L. Joergensen, Poul E. Pedersen, Joergen Petersen, Torben K. Nielsen, Jan M. Mikkelsen
  • Rhamnogalacturonase, corresponding DNA sequence, rhamnogalacturonase containing enzyme preparation and use of the enzyme preparation
    Patent number: 5538884
    Abstract: The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus japonicus which (a) has a pH-optimum between 6.5 and 7.0; (b) retains at least 80% of the maximal activity throughout the pH range of 5.5-12; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 20.degree.-60.degree. C. The present invention relates to rhamnogalacturonases derived from a stain of Aspergillus aculeatus which (a) has a pH-optimum of about 5.0; (b) retains at least 80% of the maximal activity throughout the pH range of 3-6.5; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 5.degree.-50.degree. C.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: July 23, 1996
    Assignee: Novo Nordisk A/S
    Inventors: Kurt D orreich, Henrik Dalb.o slashed.ge, Jan M. Mikkelsen, Flemming M. Christensen, Torben Halkier
  • Enzymatic detergent composition and method for enzyme stabilization
    Patent number: 5527487
    Abstract: The invention relates to a detergent composition comprising a protease and one or more other enzymes, as well as comprising a reversible protease inhibitor of the peptide or protein type.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: June 18, 1996
    Assignee: Novo Nordisk A/S
    Inventors: Jan M. Mikkelsen, Lone K. Hansen
  • .beta.-1,4-galactanase and a DNA sequence
    Patent number: 5474922
    Abstract: The present invention relates to .beta.-1,4-galactanase derived from A. aculeatus which have (a) a pH-optimum between 3.0 and 5.0, (b) an isoelectric point of 2.5-3.5, (c) a molecular weight of between 30,000 and 50,000, and (d) a temperature optimum between 10.degree. and 50.degree. C.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: December 12, 1995
    Assignee: Novo Nordisk A/S
    Inventors: Kurt Dorreich, Henrik Dalboge, Jan M. Mikkelsen, Marcel Mischler, Flemming M. Christensen
  • Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
    Patent number: 5371198
    Abstract: A process for the microbial production of a protein susceptible to inactivation in a fluid production medium by continuously and reversibly protecting said protein against said inactivation during the production stage, separating the protein from the production medium, deprotecting the protein, and recovering the protein product. The process is especially useful for obtaining substantially increased yields of the protein in question by continuously precipitating said protein.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: December 6, 1994
    Assignee: Novo Nordisk A/S
    Inventors: Per L. Joergensen, Poul E. Pedersen, Joergen Petersen, Torben K. Nielsen, Jan. M. Mikkelsen