Patents by Inventor Jan M. R. Balzarini

Jan M. R. Balzarini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonate substituted pyrimidine compounds and methods for therapy
    Patent number: 7115592
    Abstract: Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: October 3, 2006
    Assignees: Institute of Organic Chemistry, Biochemistry of the Academy of Sciences of the Czech Republic
    Inventors: Jan M. R. Balzarini, Erik D. A. De Clercq, Antonin Holy, Dana Hockova
  • Antiviral compounds and methods for synthesis and therapy
    Patent number: 6818633
    Abstract: Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: November 16, 2004
    Assignees: Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Jan M. R. Balzarini, Erik D. A. De Clercq, Antonin Holy
  • Novel compounds and methods for therapy
    Publication number: 20030109499
    Abstract: Novel compounds are provided having formula (I) 1
    Type: Application
    Filed: June 28, 2002
    Publication date: June 12, 2003
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES
    Inventors: Jan M. R. Balzarini, Erik D. A. De Clercq, Antonin Holy
  • N3-alkyl-2',5'-0-silylated-3'-spiro-thymidine derivatives
    Patent number: 5527900
    Abstract: Nucleoside analogs possessing anti-HIV activity and having a 3'-spiro moiety and blocking groups at the 2'- and 5'-positions. The preferred species is shown in the structure below: ##STR1## wherein R is alkyl.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: June 18, 1996
    Assignees: Stitching Rega VZW, Consejo Superior de Investigaciones Instituto de Quimica Medica
    Inventors: Jan M. R. Balzarini, Erik D. A. De Clerco, Maria-Jose Camarasa-Rius, Maria J. Perez-Perez, Ana San-Felix-Garcia
  • Combinations of TS-inhibitors and viral TK-inhibitors in antiherpetic medicines
    Patent number: 5137724
    Abstract: The antiviral activity of 5-fluoro-uracil, 5-fluoro-2'-deoxyuridine and similar thymilydate synthetase inhibitors towards herpes viruses can be potentiated dramatically by combining these compounds with compounds having viral thymidine kinase inhibiting activity.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: August 11, 1992
    Assignee: Stichting Rega VZW
    Inventors: Jan M. R. Balzarini, Erik D. A. De Clercq
  • Therapeutic application of dideoxycytidinene
    Patent number: 5116822
    Abstract: The compound 2',3'-dideoxycytidinene has an antiviral effect against human immunodeficiency virus (HIV) and may therefore be used as a therapeutic agent for treating AIDS and related diseases.
    Type: Grant
    Filed: July 2, 1990
    Date of Patent: May 26, 1992
    Assignees: Stichting Rega VZW, The United States of America as represented by the Department of Health and Human Serices
    Inventors: Erik D. A. De Clercq, Piet A. M. M. Herdewijn, Samuel Broder, Jan M. R. Balzarini
  • Therapeutic application of dideoxycytidinene
    Patent number: 4963533
    Abstract: The present invention relates to a composition containing the compound 2', 3'-dideoxycytidinene which has an antiviral effect against human immunodeficiency virus (HIV) and may therefore be used as a therapeutic agent for the treatment of AIDS and AIDS related diseases.
    Type: Grant
    Filed: October 24, 1986
    Date of Patent: October 16, 1990
    Assignees: Stichting Rega VZW (REGA), The Government of the United States of America
    Inventors: Erik D. A. de Clercq, Piet A. M. M. Herdewijn, Samuel Broder, Jan M. R. Balzarini