Abstract: Embodiments of the present invention include a method (10) for assessing a patient for cardiovascular risk. The method includes the steps of: drawing a first blood sample from a patient in a fasting condition; administering a liquid based protein meal to the patient; drawing a second blood sample from the patient after a time period of 60-120 minutes after the step of administering the meal; measuring HDL3-P of the first blood sample so as to determine a fasting HDL3-P amount (20); measuring HDL3-P of the second blood sample so as to determine a postprandial HDL3-P amount (30); comparing the fasting HDL3-P amount and the postprandial HDL3-P amount; and detecting cardiovascular risk based on the comparison.

Abstract: Methods and compositions related to lipoproteins reactions are provided. Particularly, quantitation of lipoprotein subgroup particle numbers may be used to detect lipoprotein's response to oxidation conditions and incubation conditions. In further aspects, ultracentrifugation may be improved to analyze the lipoprotein profiles. Embodiments are directed to methods for generating a oxidation susceptibility measure for serum lipoproteins. In certain aspects a first portion of a serum sample is used to generate a base lipid particle profile (LPP) and a second portion of the serum sample is used to generate an oxidized lipid particle profile.

Abstract: The method for treating cardiovascular disease relates to stopping growth of an atherosclerotic plaque or lesion. A therapeutically effective amount of a pharmaceutically acceptable gallium compound is administered to an inflammation site in an artery with a lesion with microcalcifications. Gallium ions bind to the lesion. The proper amount of gallium compound delivered to the lesion disrupts a calcification process at the inflammation site. The gallium ions bind to calcium hydroxyapatites in microcalcifications so that the microcalcifications can no longer differentiate into early phase osteoblasts. The gallium integrated into the calcium structures at the inflammation site has a lasting effect to reduce atherosclerotic plaques.

Abstract: The method for treating cardiovascular disease relates to stopping growth of an atherosclerotic plaque or lesion. A therapeutically effective amount of a pharmaceutically acceptable gallium compound is administered to an inflammation site in an artery with a lesion with microcalcifications. Gallium ions bind to the lesion. The proper amount of gallium compound delivered to the lesion disrupts a calcification process at the inflammation site. The gallium ions bind to calcium hydroxyapatites in microcalcifications so that the microcalcifications can no longer differentiate into early phase osteoblasts. The gallium integrated into the calcium structures at the inflammation site has a lasting effect to reduce atherosclerotic plaques.

Abstract: A system and method for assessing a patient includes a portable device for measuring a plurality of autonomic nervous system activities so as to form a baseline profile in a processor connected to the device. The baseline profile corresponds to an initial patient status before an impact event. A biomarker profile is determined by a parasympathetic ANS measurement and parasympathetic and sympathetic ANS measurement based on the baseline profile and a projected patient status for a traumatic brain injury. The device measures the plurality of autonomic nervous system activities after an impact event so as to form a test profile. The test profile is compared to the biomarker profile in a memory of the processor so as to form an injury index. When the injury index is equal or greater than a predetermined level, a traumatic brain injury is detected. An interactive display can indicate the traumatic brain injury.

Abstract: Methods and compositions related to lipoproteins reactions are provided. Particularly, quantitation of lipoprotein subgroup particle numbers may be used to detect lipoprotein's response to oxidation conditions and incubation conditions. In further aspects, ultracentrifugation may be improved to analyze the lipoprotein profiles. Embodiments are directed to methods for generating a oxidation susceptibility measure for serum lipoproteins. In certain aspects a first portion of a serum sample is used to generate a base lipid particle profile (LPP) and a second portion of the serum sample is used to generate an oxidized lipid particle profile.

Abstract: The method for treating traumatic brain injury in an individual includes the step of administering a therapeutically effective amount of a pharmaceutically acceptable gallium compound to a blood brain barrier of the individual within a therapeutically effective time period subsequent to the injury so as to reduce secondary injury in a brain of the individual. Secondary injuries include swelling of the brain after the initial injury, secondary lesions, hematomas, and edema. The effective amount and effective time period for the step of administering are established by test results disclosed in the present invention. Gallium compounds are shown to reduce oxidative stress levels in the brain, a metric for treatment of traumatic brain injury or concussion.

Abstract: The method for treating traumatic brain injury in an individual includes the step of administering a therapeutically effective amount of a pharmaceutically acceptable gallium compound to a blood brain barrier of the individual within a therapeutically effective time period subsequent to the injury so as to reduce secondary injury in a brain of the individual. Secondary injuries include swelling of the brain after the initial injury, secondary lesions, hematomas, and edema. The effective amount and effective time period for the step of administering are established by test results disclosed in the present invention. Gallium compounds are shown to reduce oxidative stress levels in the brain, a metric for treatment of traumatic brain injury or concussion.

Abstract: Disclosed is a method of treating concussion or other brain trauma in humans or other mammals by administering an effective dose of a gallium compound or gallium complex to the injured human or other mammal. The gallium compound may comprise, e.g., gallium nitrate, a docosahexaenonic acid salt of gallium with one to three of the gallium ligands being from docosahexaenonic acid, or other gallium compound or complex or combinations thereof. The gallium compound or complex may be administered orally, by spray, intravenously, subcutaneously, transdermally, intramuscularly, mucoadhesively or through oral or nasal inhalation. A transdermal patch containing the gallium compound may be applied after onset of the concussion or other brain trauma to permit rapid delivery of the compound through the skin. The gallium compound is preferably administered in an amount sufficient to maintain steady state blood concentrations. A preferred dosing is about 0.5 to about 20.0 mg/kg/day of body weight.

Abstract: A new lipoprotein analysis procedure based on the CDC gold standard, analytical ultra centrifugation, having dramatically reduced the time and cost to obtain a result with a self generating continuous gradient. The method allows quantification of the risk factors of cardiovascular disease based on particle numbers of the particles of various groups and subgroups of lipoproteins.

Abstract: A new lipoprotein analysis procedure based on the CDC gold standard, analytical ultra centrifugation, having dramatically reduced the time and cost to obtain a result with a self generating continuous gradient. The method allows quantification of the risk factors of cardiovascular disease based on particle numbers of the particles of various groups and subgroups of lipoproteins.

Abstract: A new lipoprotein analysis procedure based on the CDC gold standard, analytical ultra centrifugation, having dramatically reduced the time and cost to obtain a result with a self generating continuous gradient. The method allows quantification of the risk factors of cardiovascular disease based on particle numbers of the particles of various groups and subgroups of lipoproteins.

Abstract: An improved alternative breathable gas source for underwater breathing to be used in combination with a main air tank and a pressure regulator connected to a main air tank. The improvement comprises combining an auxiliary air tank having a manifold and pressure regulator, where the manifold is in fluid communication with the main air tank and is provided with a check valve therein for precluding air flow from the manifold to the main air tank. Thus when the main air tank is filled with pressurized air, the auxiliary air tank is also filled with pressurized air, but should the main air tank become depressured, the check valve prevents air flow from the auxiliary air tank to the main tank. The improvement also comprises an alternate air supply system having an auxiliary air tank where the auxiliary air tank is in combination with a pressure regulator that regulates air to a pressure for comfortable breathing.