Patents by Inventor Jan Martin Berke

Jan Martin Berke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO HBV CORE PROTEIN ASSAY
    Publication number: 20230228736
    Abstract: Provided herein is a method of identifying a compound that induces the formation of Hepatitis B Virus (HBV) aberrant viral capsid structures.
    Type: Application
    Filed: October 1, 2021
    Publication date: July 20, 2023
    Inventors: Jan Martin BERKE, Sarah SAUVILLER, Karen Maya VERGAUWEN, Steffen JAENSCH, Emmanuel Marie Paul Ernest GUSTIN
  • FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
    Publication number: 20230091047
    Abstract: The present application relates to compounds according to Formula (I), pharmaceutical compositions comprising at least one of said compounds, their use as a medicament, and their use in treating chronic hepatitis B virus (HBV) infection. The disclosure further pertains to methods for preparing compounds according to Formula (I).
    Type: Application
    Filed: March 13, 2020
    Publication date: March 23, 2023
    Inventors: Sandrine Céline GROSSE, Jan Martin BERKE, Meng-yang HSIAO, Lili HU, Edgar JACOBY, Tim Hugo Maria JONCKERS, Bart Rudolf Romanie KESTELEYN, Stefaan Julien LAST, Carlolina MARTINEZ LAMENCA, Mathieu PERRIER, Serge Maria Aloysius PIETERS, Pierre Jean-Marie Bernard RABOISSON, Abdellah TAHRI, Koen VANDYCK, Wim Gaston VERSCHUEREN
  • Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
    Patent number: 11491148
    Abstract: The application relates to amide derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their uses, more particularly their uses in treating chronic hepatitis B virus (HBV) infection:
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: November 8, 2022
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Bart Rudolf Romanie Kesteleyn, Jan Martin Berke, Erwin Coesemans, Sandrine Céline Grosse, Edgar Jacoby, Tim Hugo Maria Jonckers, Stefaan Julien Last, Wim Gaston Verschueren, Michel Obringer, Christelle Catherine Cecile Doebelin
  • FUSED HETEROCYCLIC DERIVATIVES
    Publication number: 20220348592
    Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.
    Type: Application
    Filed: May 27, 2020
    Publication date: November 3, 2022
    Inventors: Sandrine Celine GROSSE, Scott D. KUDUK, Lindsey Graham DERATT, Koen VANDYCK, Pierre Jean-Marien Bernard RABOISSON, Serge Maria Aloysius PIETERS, Bart Rudolf Romanie KESTELEYN, Wim Gaston VERSCHUEREN, Jan Martin BERKE, Morgan Charles R. LECOMTE, Carolina MARTINEZ LAMENCA, Tim Hugo Maria JONCKERS, Gang DENG, Yimin JIANG, Yanping XU, Zhangling CHENG, Lili HU
  • FUSED HETEROCYCLIC DERIVATIVES AS ANTIVIRAL AGENTS
    Publication number: 20220323455
    Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.
    Type: Application
    Filed: May 27, 2020
    Publication date: October 13, 2022
    Inventors: Scott D. KUDUK, Lindsey Graham DERATT, Chao-Yuan WANG, Jan Martin BERKE
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
    Publication number: 20220305107
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and an RNAi agent for inhibiting the expression of an HBV gene are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, An Martine M. DE CREUS, Jan Martin BERKE
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND DIHYDROPYRIMIDINE DERIVATIVES AS CAPSID ASSEMBLY MODULATORS
    Publication number: 20220249647
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and capsid assembly modulators are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: August 11, 2022
    Inventors: Helen HORTON, Jan Martin BERKE, Frederik PAUWELS
  • FUSED HETEROCYCLE DERIVATIVES
    Publication number: 20220242879
    Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.
    Type: Application
    Filed: May 27, 2020
    Publication date: August 4, 2022
    Inventors: Scott D. KUDUK, Christelle Catherine Cecile DOEBELIN, Abdellah TAHRI, Sandrine Céline GROSSE, Stefaan Julien LAST, Lindsey Graham DERATT, Koen VANDYCK, Pierre Jean-Marie Bernard RABOISSON, Jan Martin BERKE, Wim Gaston VERSCHUEREN, Michel OBRINGER
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND DIHYDROPYRIMIDINE DERIVATIVES AS CAPSID ASSEMBLY MODULATORS
    Publication number: 20220233526
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and capsid assembly modulators are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: July 28, 2022
    Inventors: Helen HORTON, Jan Martin BERKE, Frederik PAUWELS
  • Combinations and methods comprising a capsid assembly inhibitor
    Patent number: 11129834
    Abstract: The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: September 28, 2021
    Assignees: Novira Therapeutics, Inc., Janssen Sciences Ireland Unlimited Company
    Inventors: George Hartman, Osvaldo Flores, Klaus Klumpp, Man Iu Lam, Jan Martin Berke
  • Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
    Patent number: 11096931
    Abstract: The application relates to amide derivatives, processes for their preparation, pharmaceutical compositions, and their uses, more particularly their uses in treating chronic hepatitis B virus (HBV) infection.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: August 24, 2021
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Stefaan Julien Last, Bart Rudolf Romanie Kesteleyn, Sandrine Céline Grosse, Tim Hugo Maria Jonckers, Jan Martin Berke, Geerwin Yvonne Paul Haché, Edgar Jacoby, Carolina Martinez Lamenca, Morgan Charles R. Lecomte, Abdellah Tahri, Sarah Sauviller, Karen Maria Vergauwen
  • AMIDE DERIVATIVES USEFUL IN THE TREATMENT OF HBV INFECTION OR HBV-INDUCED DISEASES
    Publication number: 20200352925
    Abstract: The application relates to amide derivatives, processes for their preparation, pharmaceutical compositions, and their uses, more particularly their uses in treating chronic hepatitis B virus (HBV) infection.
    Type: Application
    Filed: May 5, 2020
    Publication date: November 12, 2020
    Inventors: Bart Rudolf Romanie KESTELEYN, Jan Martin BERKE, Erwin COESEMANS, Sandrine Céline GROSSE, Edgar JACOBY, Tim Hugo Maria JONCKERS, Stefaan Julien LAST, Wim Gaston VERSCHUEREN, Michel OBRINGER, Christelle Catherine Cecile DOEBELIN
  • AMIDE DERIVATIVES USEFUL IN THE TREATMENT OF HBV INFECTION OR HBV-INDUCED DISEASES
    Publication number: 20200268730
    Abstract: The application relates to amide derivatives, processes for their preparation, pharmaceutical compositions, and their uses, more particularly their uses in treating chronic hepatitis B virus (HBV) infection.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 27, 2020
    Inventors: Stefaan Julien LAST, Bart Rudolf Romanie KESTELEYN, Sandrine Céline GROSSE, Tim Hugo Maria JONCKERS, Jan Martin BERKE, Geerwin Yvonne Paul HACHÉ, Edgar JACOBY, Carolina MARTINEZ LAMENCA, Morgan Charles R. LECOMTE, Abdellah TAHRI
  • COMBINATIONS AND METHODS COMPRISING A CAPSID ASSEMBLY INHIBITOR
    Publication number: 20190365767
    Abstract: The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.
    Type: Application
    Filed: August 15, 2019
    Publication date: December 5, 2019
    Inventors: George Hartman, Osvaldo Flores, Klaus Klumpp, Man Iu Lam, Jan Martin Berke
  • Combinations and methods comprising a capsid assembly inhibitor
    Patent number: 10441589
    Abstract: The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: October 15, 2019
    Assignees: NOVIRA THERAPEUTICS, INC., Janssen Sciences Ireland Unlimited Company
    Inventors: George Hartman, Osvaldo Flores, Klaus Klumpp, Man Iu Lam, Jan Martin Berke
  • COMBINATIONS AND METHODS COMPRISING A CAPSID ASSEMBLY INHIBITOR
    Publication number: 20170340642
    Abstract: The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.
    Type: Application
    Filed: April 14, 2017
    Publication date: November 30, 2017
    Inventors: George HARTMAN, Osvaldo FLORES, Klaus KLUMPP, Man Iu LAM, Jan Martin BERKE
  • METHOD FOR DETERMINING DRUG RESISTANCE MUTATIONS IN ANY OF THE NON-STRUCTURAL PROTEIN REGIONS NS3 TO NS5B OF HEPATITIS C VIRUS (HCV) FOR GENOTYPES 1 TO 6
    Publication number: 20160177407
    Abstract: The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more in particular for subtype specific genotypes 1a, 1b, 2a, 2b, 3a, 4a and 4d.
    Type: Application
    Filed: December 22, 2014
    Publication date: June 23, 2016
    Inventors: Diana Koletzki, Jan Martin Berke, Ina Isabel Vandenbroucke, Leen Roger Vijgen
  • Method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of hepatitis C virus (HCV) for genotypes 1 to 6
    Patent number: 8945833
    Abstract: The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more in particular for subtype specific genotypes 1a, 1b, 2a, 2b, 3a, 4a and 4d.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: February 3, 2015
    Inventors: Lieven Jozef Stuyver, Diana Koletzki, Jan Martin Berke, Ina Isabel Vandenbroucke, Leen Roger Vijgen
  • METHOD FOR DETERMINING DRUG RESISTANCE MUTATIONS IN ANY OF THE NON-STRUCTURAL PROTEIN REGIONS NS3 TO NS5B OF HEPATITIS C VIRUS (HCV) FOR GENOTYPES 1 TO 6
    Publication number: 20110189684
    Abstract: The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more in particular for subtype specific genotypes 1a, 1b, 2a, 2b, 3a, 4a and 4d.
    Type: Application
    Filed: October 6, 2009
    Publication date: August 4, 2011
    Inventors: Lieven Jozef Stuyver, Diana Koletzki, Jan Martin Berke, Ina Isabel Vandenbroucke, Leen Roger Vijgen