Patents by Inventor Jan Mikkelson

Jan Mikkelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein complexes having factor VIII:C activity and production thereof
    Publication number: 20060122376
    Abstract: Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an .alpha.sub.1-antitrypsin signal sequence.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 8, 2006
    Applicant: Chiron Corporation
    Inventors: Barbara Chapman, Rae Burke, Mirella Rasmussen, Jan Mikkelson