Patents by Inventor Jan Mrazek

Jan Mrazek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11603392
    Abstract: Disclosed herein are major vault proteins having modified R8 flexible regions, vault particles comprising major vault proteins having modified R8 flexible regions, and methods of packaging passenger polypeptides in the modified R8 flexible regions.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 14, 2023
    Assignee: The Regents of the University of California
    Inventors: Otto O. Yang, Ke Ding, Jan Mrazek, Z. Hong Zhou
  • Patent number: 10821190
    Abstract: Disclosed herein are compositions comprising HIV peptide vaults, which are vault particles comprising complexes of MVP proteins and one or more HIV peptides bound or genetically linked to one or more MVP proteins or packaged within the internal cavities of the vault particles and methods of using thereof.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 3, 2020
    Assignee: The Regents of the University of California
    Inventors: Otto O. Yang, Leonard H. Rome, Jan Mrazek
  • Publication number: 20200255488
    Abstract: Disclosed herein are major vault proteins having modified R8 flexible regions, vault particles comprising major vault proteins having modified R8 flexible regions, and methods of packaging passenger polypeptides in the modified R8 flexible regions.
    Type: Application
    Filed: October 30, 2018
    Publication date: August 13, 2020
    Inventors: Otto O. Yang, Ph.D., Ke Ding, Jan Mrazek, Ph.D., Z. Hong Zhou, Ph.D.
  • Patent number: 10537529
    Abstract: Disclosed herein are methods of making vaults and packaging one or more passenger molecules in the internal cavities of the vault particles using cell-free techniques. Vaults according to the present invention and compositions comprising the vaults are free of cellular debris.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: January 21, 2020
    Assignee: The Regents of the University of California
    Inventor: Jan Mrazek
  • Publication number: 20190111146
    Abstract: Disclosed herein are compositions comprising HIV peptide vaults, which are vault particles comprising complexes of MVP proteins and one or more HIV peptides bound or genetically linked to one or more MVP proteins or packaged within the internal cavities of the vault particles and methods of using thereof.
    Type: Application
    Filed: May 1, 2017
    Publication date: April 18, 2019
    Inventors: Otto O. Yang, Leonard H. Rome, Jan Mrazek
  • Publication number: 20170246119
    Abstract: Disclosed herein are methods of making vaults and packaging one or more passenger molecules in the internal cavities of the vault particles using cell-free techniques. Vaults according to the present invention and compositions comprising the vaults are free of cellular debris.
    Type: Application
    Filed: September 23, 2015
    Publication date: August 31, 2017
    Inventor: Jan Mrazek, Ph.D.
  • Patent number: 7750603
    Abstract: A regenerative agent for lead battery cells includes, for each liter of aqueous solution 40% of hydrogen peroxide, 1 ml to 70 ml of sulfuric acid with a density of 1 to 1.32 g·cm?3, 0.1 g to 10 g of saccharides in solids and/or aldehydes or their derivatives, 0.1 g to 10 g of sodium and/or potassium bicarbonate and/or at least one hydroxide from the group of alkali metal hydroxides in solids and 0.1 g to 20 g, with an advantage 0.5 g to 2 g, of bisodium dinaphthylmethane disulfonic acid salt. The regenerative agent can also contain 0.1 g to 10 g of peroxoborate an/or tetraborate and/or sodium pyrophosphate in solids.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: July 6, 2010
    Assignee: Akuros s.r.o.
    Inventor: Jan Mrázek
  • Publication number: 20090140695
    Abstract: The electrochemical regeneration of lead battery cells during which, after the treatment of the battery by some of the regeneration additives on the basis of an aqueous solution of hydrogen peroxide and after the basic charging, they are alternately or intermittently charged and discharged. Above the limit located above the level of the full charge it is charged with a current of 1.1%-4% and discharged with a current of 0%-5% related to the nominal value of the capacity of the cell or storage battery, or else the charging is carried out in two phases or by a constant current. Under the limit located below the level of the permitted discharging it is discharged with a current of 1% to 4% and subsequently charged with a current of 3%-10% related to the value of the capacity of the battery to a decrease in the voltage to 1.6 V of the cell or any of the battery's cells. Then the battery supplies 10%-15% of its nominal capacity and this entire procedure is repeated 2-5 times.
    Type: Application
    Filed: December 22, 2008
    Publication date: June 4, 2009
    Inventor: Jan Mrazek
  • Publication number: 20060145664
    Abstract: The electrochemical regeneration of lead and alkaline battery cells during which, after the treatment of the battery by some of the regeneration additives on the basis of an aqueous solution of hydrogen peroxide and after the basic charging, they are alternately or internnittently charged and discharged. Above the limit located above the level of the full charge it is charged with a current of 1.1%-4% and discharged with a current of 0%-5% related to the nominal value of the capacity of the cell or storage battery, or else the charging is carried out in two phases or by a constant current. Under the limit located below the level of the permitted discharging it is discharged with a current of 1% to 4% and subsequently charged with a current of 3%-10% related to the value of the capacity of the battery to a decrease in the voltage to 1.6 V of the cell or any of the battery's cells. Then the battery supplies 10%-15% of its nominal capacity and this entire procedure is repeated 2-5 times.
    Type: Application
    Filed: March 10, 2004
    Publication date: July 6, 2006
    Inventor: Jan Mrazek