Patents by Inventor Jan Nolta

Jan Nolta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY MODIFIED MSC AND THERAPEUTIC METHODS
    Publication number: 20240425878
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Application
    Filed: February 8, 2024
    Publication date: December 26, 2024
    Applicant: The Regents of the University of California
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • Genetically modified MSC and therapeutic methods
    Patent number: 11939591
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: March 26, 2024
    Assignee: The Regents of the University of California
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • GENETICALLY MODIFIED MSC AND THERAPEUTIC METHODS
    Publication number: 20220002748
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Application
    Filed: February 5, 2021
    Publication date: January 6, 2022
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • Genetically modified MSC and therapeutic methods
    Patent number: 10913957
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: February 9, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • GENETICALLY MODIFIED MSC AND THERAPEUTIC METHODS
    Publication number: 20190276843
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Application
    Filed: October 5, 2018
    Publication date: September 12, 2019
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • VECTORS AND METHODS TO TREAT ISCHEMIA
    Publication number: 20180022787
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Application
    Filed: May 29, 2017
    Publication date: January 25, 2018
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • GENETICALLY MODIFIED MSC AND THERAPEUTIC METHODS
    Publication number: 20170314042
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Application
    Filed: November 14, 2016
    Publication date: November 2, 2017
    Applicant: The Regents of the University of California
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • Vectors and methods to treat ischemia
    Patent number: 9663564
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 30, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • MESENCHYMAL STEM CELLS FOR TARGETED CANCER THERAPY
    Publication number: 20170000886
    Abstract: An isolated polynucleotide comprising the element of: a promoter element that drives expression of the C—C motif ligand 5 (“a CCL5 promoter”) operatively linked to a polynucleotide encoding a fusion polypeptide comprising the Fc and hinge regions of a human IgG CD44 variant 6 (CD44v6) polypeptide is described.
    Type: Application
    Filed: June 22, 2016
    Publication date: January 5, 2017
    Inventors: Astra Chang, Jan Nolta
  • VECTORS AND METHODS TO TREAT ISCHEMIA
    Publication number: 20160046685
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • GENETICALLY MODIFIED MSC AND THERAPEUTIC METHODS
    Publication number: 20140065110
    Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 6, 2014
    Applicant: The Regents of the University of California
    Inventors: Jan Nolta, Karen Pepper, Fernando Fierro, Gerhard Bauer
  • DECELLULARIZED LIVER TRANSPLANTATION COMPOSITION AND METHODS
    Publication number: 20140023624
    Abstract: This disclosure provides an isolated or purified decellularized liver extracellular matrix (DLM) composition containing an isolated or purified cell capable of differentiating into a hepatocyte and/or liver tissue, and methods for its use in vitro and in vivo.
    Type: Application
    Filed: December 30, 2011
    Publication date: January 23, 2014
    Inventors: Ping Zhou, Jian Wu, Jan Nolta