Patents by Inventor Jan P. Kraus

Jan P. Kraus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20240091325
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: August 23, 2023
    Publication date: March 21, 2024
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 11771745
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: October 3, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • OPTIMIZATION OF ENZYME REPLACEMENT THERAPY FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20230039591
    Abstract: The present invention provides a method of PEGylating a human truncated cystathionine ?-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.
    Type: Application
    Filed: April 5, 2022
    Publication date: February 9, 2023
    Inventors: Tomas Majtan, Jan P. Kraus, Erez M. Bublil, Frank Glavin, Marcia Sellos-Moura
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20230042914
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: June 28, 2022
    Publication date: February 9, 2023
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • PEGYLATED CYSTATHIONINE BETA SYNTHASE FOR ENZYME THERAPY FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20220265835
    Abstract: The present disclosure provides formulations for a drug product comprising a PEGylated CBS protein having the amino acid sequence of SEQ ID NO: 1. Dosages and dosing regimens are provided for treatment of homocystinuria in a subject in need thereof. Additionally, the dosages and dosing regimens are also provided to reduce the level of homocysteine (Hcy) or increase the levels of cysteine (Cys) and/or cystathionine (Cth) in a subject in need thereof.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 25, 2022
    Inventors: Erez Bublil, Frank Glavin, Marcia Sellos-Moura, Jan P. Kraus, Tomas Majtan, Randy Wanner, Orhan Causevic
  • Compositions and methods for treatment of homocystinuria
    Patent number: 11400143
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: August 2, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Optimization of enzyme replacement therapy for treatment of homocystinuria
    Patent number: 11324811
    Abstract: The present invention provides a method of PEGylating a human truncated cystathionine ?-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: May 10, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, TRAVERE THERAPEUTICS SWITZERLAND GMBH
    Inventors: Tomas Majtan, Jan P. Kraus, Erez M. Bublil, Frank Glavin, Marcia Sellos-Moura
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20220125896
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: June 29, 2021
    Publication date: April 28, 2022
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 11077175
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: August 3, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Purification of cystathionine beta-synthase
    Patent number: 10941392
    Abstract: This invention provides chromatographic methods for the purification of a cystathionine ?-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: March 9, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Richard Carrillo, Jan P. Kraus, Tomas Majtan, David Naveh
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20200316179
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: June 24, 2020
    Publication date: October 8, 2020
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20200276282
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: March 20, 2020
    Publication date: September 3, 2020
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • OPTIMIZATION OF ENZYME REPLACEMENT THERAPY FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20200261555
    Abstract: The present invention provides a method of PEGylating a human truncated cystathionine ?-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.
    Type: Application
    Filed: April 17, 2018
    Publication date: August 20, 2020
    Inventors: Tomas Majtan, Jan P. Kraus, Erez M. Bublil, Frank Glavin, Marcia Sellos-Moura
  • Compositions and methods for treatment of homocystinuria
    Patent number: 10729753
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Compositions and methods for treatment of homocystinuria
    Patent number: 10653755
    Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: May 19, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • PURIFICATION OF CYSTATHIONINE BETA-SYNTHASE
    Publication number: 20200131497
    Abstract: This invention provides chromatographic methods for the purification of a cystathionine ?-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.
    Type: Application
    Filed: January 10, 2020
    Publication date: April 30, 2020
    Inventors: Richard Carrillo, Jan P. Kraus, Tomas Majtan, David Naveh
  • Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria
    Patent number: 10624959
    Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine ?-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: April 21, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Propionyl-CoA carboxylase compositions and uses thereof
    Patent number: 10406214
    Abstract: This invention provides compositions of human propionyl-CoA carboxylase (PCC) and pharmaceutical compositions of human PCC and methods for treating conditions such as propionic acidemia (PA), propionic aciduria, propionyl-CoA carboxylase deficiency and ketotic glycinemia.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: September 10, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Jan P. Kraus
  • Human cystathionine ?-synthase variants and methods of production thereof
    Patent number: 10280415
    Abstract: Human cystathionine ?-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine ?-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologs are described. In addition, a method to express and purify recombinant human cystathionine ?-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: May 7, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Jan P. Kraus
  • COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
    Publication number: 20190125845
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 2, 2019
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil