Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.

Abstract: An implantable article and methods of construction and use for the treatment of soft tissue defects that impact a patient's quality of life, such as a pelvic floor injury that results in urinary incontinence. The implantable article includes an implant assembly of a support member that can have anchoring zones, accelerated ingrowth zones, and support zones. The support assembly or its zones are constructed in various ways and with various materials to selectively control the location and rate of implant absorption and tissue ingrowth. The result is the formation of a tissue bridge or hybrid tissue bridge with reinforcing members.

Abstract: A set of toy construction blocks that are molded from a thermoplastic elastomer. This enables each of the blocks to elastically stretch in any direction by at least ten percent. Each toy construction block has a main body with a top surface and a bottom surface. One or more male connector protrusions extend from the top surface. One or more female connector receptacles extend into the bottom surface of the main body. At least one internal chamber is molded within the main body. The internal chamber is separate and distinct from the female connector receptacles. The internal chamber does extend into the male connector protrusions. Each internal chamber can be empty or can be filled with a fill material that does not inhibit the pliability of the main body. The fill material can be liquid, gel and lubricated particles and is preferably visible through the molded thermoplastic elastomer.

Abstract: An example operation includes one or more of establishing a network channel between a network interface of a computing system and a network interface of a remote computing system coupled to an electronic control unit (ECU), receiving, via a hardware interface of the computing system, a CAN message from a hardware element that is coupled to the hardware interface, converting the CAN message into an Ethernet packet message, and forwarding the Ethernet packet message to the ECU on the remote computing system via the established network channel.

Abstract: An example operation includes one or more of establishing a network connection between a plurality of ECUs via a bus, receiving a request to perform a software test, dynamically configuring a subset of ECUs among the plurality of ECUs for executing the software test via the bus, and executing the software test via the dynamically configured subset of ECUs, wherein the executing comprises exchanging messages between only the subset of ECUs rather than the plurality of ECUs based on the dynamic configuration.

Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.

Abstract: The invention relates to a method for obtaining APRIL-binding peptides. With this method APRIL-binding peptides may be obtained and/or selected. Further aspects of the invention relate to a cell comprising a nucleotide sequence coding for an APRIL-binding peptide according to the invention, a process for producing an APRIL-binding peptide and the APRIL-binding peptide obtainable in the production process and/or the selection method. In view of the possible utility of the APRIL-binding peptides according to the invention, further aspects of the invention relate to diagnostic uses of an APRIL binding peptide of the invention.

Abstract: A quetiapine fumarate composition for oral administration is provided comprising a pharmaceutically acceptable salt or solvate of quetiapine existing as a suspension in an aqueous carrier agent. The inventive liquid formulation demonstrates high bioavailability consistent with approved dosage forms, low agglomeration, reduced content of excipients commonly used in solid oral dosage forms and extended shelf life stability. Also provided is a method of manufacturing a liquid quetiapine suspension composition for oral administration and methods of administering therapeutically effective dosages of an oral liquid quetiapine suspension composition to patients in need thereof.

Abstract: A collapsible intermodal shipping container is provided. The container includes door frame posts and sidewalls that are each segmented into long and short portions that enable the door frames and sidewalls to articulate. When collapsed, the long portions of the door frame posts lie folded at right angles to the short portions of the door frame posts and the long portions of the sidewalls lie folded at right angles to the short portions of the sidewalls.

Abstract: A method for producing a polymer coated metal strip in a continuous coating line, including the subsequent steps of: laminating a thermoplastic polymer film onto at least one side of a metal strip to produce a polymer coated metal strip; post-heating the polymer coated metal strip to temperature sufficiently high to melt the thermoplastic polymer film to reduce orientation and crystallinity of the thermoplastic polymer film to target value; cooling the post-heated polymer coated metal strip; in-line illuminating the laminated polymer film with near-infrared light having one or more or all wavenumbers between 3500 and 9000 cm?1; in-line acquiring back-scattered near-infrared light with a near-infrared spectroscopy detector; calculating near-infrared spectrum from the back-scattered near-infrared light; comparing the calculated near-infrared spectrum to a reference material near-infrared spectrum to determine Conformity Index as measure of the laminated polymer film degree of crystallinity and/or molecular o

Abstract: An example method performed for a circuit path includes: receiving signals in the circuit path; and controlling states of the signals in the circuit path based on skews produced by circuits electrically connected in series in the circuit path. The states are controlled by inverting or not inverting the signals in the circuit path so that skews produced by different circuits in the circuit paths at least partially cancel.

Abstract: A quetiapine fumarate composition for oral administration is provided comprising a pharmaceutically acceptable salt or solvate of quetiapine existing as a suspension in an aqueous carrier agent. The inventive liquid formulation demonstrates high bioavailability consistent with approved dosage forms, low agglomeration, reduced content of excipients commonly used in solid oral dosage forms and extended shelf life stability. Also provided is a method of manufacturing a liquid quetiapine suspension composition for oral administration and methods of administering therapeutically effective dosages of an oral liquid quetiapine suspension composition to patients in need thereof.

Abstract: The invention relates to a method for obtaining APRIL-binding peptides. With this method APRIL-binding peptides may be obtained and/or selected. Further aspects of the invention relate to a cell comprising a nucleotide sequence coding for an APRIL-binding peptide according to the invention, a process for producing an APRIL-binding peptide and the APRIL-binding peptide obtainable in the production process and/or the selection method. In view of the possible utility of the APRIL-binding peptides according to the invention, further aspects of the invention relate to diagnostic uses of an APRIL binding peptide of the invention.

Abstract: A gripping apparatus for gripping a sample container comprising: a gripper body comprising a gripper actuator; at least two gripper fingers each comprising a gripping surface, wherein at least one of the gripper fingers is movably coupled to the gripper body, and wherein the gripping apparatus is designed for gripping a sample container with the gripping surfaces of the at least two gripper fingers by moving the at least one movable gripper finger; and characterized in that the gripping apparatus comprises at least one elastically mounted contacting surface for elastically contacting a sample container about to be gripped by the gripping apparatus.

Abstract: A polymer film for laminating onto a metal substrate (M), the polymer film including an adhesion layer (A) and a bulk layer (B), wherein the adhesion layer is intended for bonding to the metal substrate and includes 20 to 50 wt. % of a non-crystallisable copolyester, 50 to 80 wt. % of polybutylene terephthalate (PBT) and 0-10 wt. % of polymers and additives, and wherein the bulk layer consists of is at least 91 wt. % of PBT and at most 9% of other polymers and additives.

Abstract: A method for passivating a tinplate strip after electrodepositing the tin layer or tin layers, or after an optional flow-melting of the electrodeposited tin layer or tin layers, and an apparatus for producing the passivated tinplate strip.

Abstract: A method of producing a laminated metal sheet for packaging applications and laminated metal sheet for packaging applications produced thereby.

Abstract: A method for producing polymer coated steel sheet for 3-piece cans and 3-piece cans produced thereof.

Abstract: A method for manufacturing a laminated tinplate for packaging applications, the laminated tinplate including a tinplate sheet and a thermoplastic laminate layer that covers at least one side of the tinplate steel sheet, to a laminated tinplate produced thereby and use thereof in a process to produce containers for packaging purposes.

Abstract: Circuitry and methods of operating the same to strobe a DQ signal with a gated DQS signal are described. Some aspects are directed to a gating scheme to selectively pass a received strobe signal such as a DQS strobe signal based on a state of a drive enable (DE) signal in a drive circuit in the ATE, such that edges generated by the drive circuit are prevented from mistakenly strobing a received data signal such as a DQ signal.