Patents by Inventor Jan-Peter Kramb

Jan-Peter Kramb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
    Patent number: 9364459
    Abstract: The present invention relates to the use of a compound of formula (I) wherein R1 and R3 are as defined in the description and R2 is a phenyl group which is substituted with 2 or 3 C1-C6 alkoxy groups, or a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) or of the salt thereof, for treatment of colorectal or gastric adenocarcinoma.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: June 14, 2016
    Assignees: Johannes Gutenberg-Universität Mainz, Universitätsmedizin der Johannes Gutenberg-Universität Mainz
    Inventors: Gerd Dannhardt, Stanislav Plutizki, Jan-Peter Kramb, Annett Müller, Markus Möhler
  • 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
    Patent number: 9012659
    Abstract: The present invention relates to a compound of formula (I) wherein R1, R2 and R3 are as defined in the description and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula I and of the salts thereof. The compounds of formula I are suitable for treating tumors.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: April 21, 2015
    Assignee: Johannes Gutenberg—Universitat Mainz
    Inventors: Gerd Dannhardt, Jan-Peter Kramb, Stanislav Plutizki
  • 3-(INDOLYL)- OR 3-(AZAINDOLYL)- 4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT
    Publication number: 20130131060
    Abstract: The present invention relates to a compound of formula (I) wherein R1, R2 and R3 are as defined in the description and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula I and of the salts thereof. The compounds of formula I are suitable for treating tumors.
    Type: Application
    Filed: December 10, 2010
    Publication date: May 23, 2013
    Applicant: Johannes Gutenberg-Universität Mainz
    Inventors: Gerd Dannhardt, Jan-Peter Kramb, Stanislav Plutizki
  • 3-(INDOLYL)- OR 3-(AZAINDOLYL)- 4-ARYLMALEIMIDE DERIVATIVES FOR USE IN THE TREATMENT OF COLON AND GASTRIC ADENOCARZINOMA
    Publication number: 20130029986
    Abstract: The present invention relates to the use of a compound of formula (I) wherein R1 and R3 are as defined in the description and R2 is a phenyl group which is substituted with 2 or 3 C1-C6 alkoxy groups, or a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) or of the salt thereof, for treatment of colorectal or gastric adenocarcinoma.
    Type: Application
    Filed: December 10, 2010
    Publication date: January 31, 2013
    Applicants: Universitatsmedizin der Johannes Gutenberg-Universitat Mainz, Johannes Gutenberg-Universitat Mainz
    Inventors: Gerd Dannhardt, Stanislav Plutizki, Jan-Peter Kramb, Annett Müller, Markus Möhler
  • 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
    Patent number: 8008320
    Abstract: The present invention relates to a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy groups and R3 is indolyl or azaindolyl which may carry one or two substituents independently selected from C1-C6-alkyl, C1-C6-alkoxy, phenyl, OH, halogen, NH2, C1-C6-alkylamino, di-C1-C6-alkylamino, heteroaryl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and heterocyclyl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula 1 and of the salts thereof. The compounds of formula (I) are suitable for controlling angiogenesis.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: August 30, 2011
    Assignee: Johannes Gutenberg-Universitatis
    Inventors: Gerd Dannhardt, Christian Peifer, Stanislav Plutizki, Jan-Peter Kramb
  • 3-(INDOLYL)-4-ARYLMALEIMIDE DERIVATIVES AND THEIR USE AS ANGIOGENESIS INHIBITORS
    Publication number: 20090306124
    Abstract: The present invention relates to a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy groups and R3 is indolyl or azaindolyl which may carry one or two substituents independently selected from C1-C6-alkyl, C1-C6-alkoxy, phenyl, OH, halogen, NH2, C1-C6-alkylamino, di-C1-C6-alkylamino, heteroaryl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and heterocyclyl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula 1 and of the salts thereof. The compounds of formula (I) are suitable for controlling angiogenesis.
    Type: Application
    Filed: December 7, 2005
    Publication date: December 10, 2009
    Applicant: Johannes Gutenberg-Universitat Mainz
    Inventors: Gerd Dannhardt, Christian Peifer, Stanislav Plutizki, Jan-Peter Kramb