Patents by Inventor Jan Potempa

Jan Potempa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis
    Patent number: 11186572
    Abstract: The present invention relates to bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis and related conditions, and provides a bacterial glutaminyl cyclase (bacQC); an antibody which recognizes the bacQC, a method for identifying an inhibitor of the bacQC; a compound according to Formula (I); a pharmaceutical composition comprising a bacQC inhibitor compound; a bacQC inhibitor compound and/or a pharmaceutical composition for use in a method for treatment of the human or animal body, for use in a method for therapy or prophylaxis of a bacterial infection, and for use in a method for therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 30, 2021
    Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.
    Inventors: Jan Potempa, Sigrun Eick, Nadine Taudte, Jens-Ulrich Rahfeld, Mirko Buchholz, Hans-Ulrich Demuth
  • BACTERIAL GLUTAMINYL CYCLASES AND INHIBITORS THEREOF FOR USE IN THE TREATMENT OF PERIODONTITIS
    Publication number: 20190367511
    Abstract: The present invention relates to bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis and related conditions, and provides a bacterial glutaminyl cyclase (bacQC); an antibody which recognizes the bacQC, a method for identifying an inhibitor of the bacQC; a compound according to Formula (I); a pharmaceutical composition comprising a bacQC inhibitor compound; a bacQC inhibitor compound and/or a pharmaceutical composition for use in a method for treatment of the human or animal body, for use in a method for therapy or prophylaxis of a bacterial infection, and for use in a method for therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.
    Type: Application
    Filed: December 1, 2017
    Publication date: December 5, 2019
    Inventors: Jan Potempa, Sigrun Eick, Nadine Taudte, Jens-Ulrich Rahfeld, Mirko Buchholz, Hans-Ulrich Demuth
  • Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis
    Patent number: 6875851
    Abstract: The present invention provides isolated polypeptides, prolyl tripeptidyl-peptidases, and active analogs, active fragments or active modifications thereof, having amidolytic activity for cleavage of a peptide bond present in a target peptide having at least 30 amino acids. Isolated nucleic acid fragments encoding isolated prolyl tripeptidyl-peptidases are also provided, as are methods of reducing growth of a bacterium by inhibiting a prolyl tripeptidyl-peptidase.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: April 5, 2005
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: James Travis, Jan Potempa, Agnieszka Banbula
  • Methods and compositions for control of blood coagulation
    Patent number: 6627193
    Abstract: Methods for controlling blood coagulation, and suitable pharmaceutical compositions that include a polypeptide that enhances the anticoagulation process (or inhibitors thereof for reversing the anticoagulation process) are provided.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: September 30, 2003
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: James Travis, Takahisa Imamura, Jan Potempa
  • Immunogenic compositions comprising porphyromonas gingivalis proteins and/or peptides and methods
    Patent number: 6129917
    Abstract: Provided herein are methods and immunogenic compositions useful for protecting mammals from infection and pathology of P. gingivalis. Specifically, arginine-specific proteases of Porphyromonas gingivalis and peptides derived therefrom offer protection against infection. Immunogenic compositions comprising a 50 kDa arginine-specific protease, the high molecular weight complex or peptides from one of the foregoing proteins are capable of protecting against P. gingivalis infection and/or gingivitis and/or periodontitis caused thereby in mammals, including humans.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: October 10, 2000
    Assignees: The University of Georgia Research Foundation, Inc., Morehouse School of Medicine
    Inventors: Jan Potempa, James Travis, Caroline Attardo Genco