Patents by Inventor Jan R. Turner

Jan R. Turner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding SPNF of the spinosyn cluster
    Patent number: 7015001
    Abstract: Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: March 21, 2006
    Assignee: Dow AgroSciences LLC
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • Biosynthetic genes for spinosyn insecticide production
    Publication number: 20040023343
    Abstract: Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.
    Type: Application
    Filed: December 23, 2002
    Publication date: February 5, 2004
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • SpnG, a gene for spinosyn insecticide biosynthesis
    Patent number: 6521406
    Abstract: Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: February 18, 2003
    Assignee: Dow AgroSciences LLC
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • Biosynthetic genes for spinosyn insecticide production
    Patent number: 6274350
    Abstract: Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: August 14, 2001
    Assignee: Dow AgroSciences LLC
    Inventors: Richard H. Baltz, Kathryn P. Crawford, M. Christine Broughton, Krishnamurthy Madduri, Donald J. Merlo, Jan R. Turner, Patti J. Treadway, Clive Waldron
  • Biosynthetic genes for spinosyn insecticide production
    Patent number: 6143526
    Abstract: Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: November 7, 2000
    Inventors: Richard H. Baltz, M. Christine Broughton, Kathryn P. Crawford, Krishnamurthy Madduri, Donald J. Merlo, Patti J. Treadway, Jan R. Turner, Clive Waldron
  • A83543 compounds and process for production thereof
    Patent number: 5840861
    Abstract: New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: February 8, 1995
    Date of Patent: November 24, 1998
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, Mary C. Broughton, Walter M. Nakatsukasa, James A. Mabe, Jan R. Turner, Lawrence Creemer, Mary L. B. Huber, Herbert A. Kirst, James W. Martin
  • A83543 Compounds; factors Q, R, S, and T
    Patent number: 5767253
    Abstract: New A83543 components, including fermentation products A83543Q, A83543R, A83543S and A83543T and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones are useful for the preparation of A83543 components. Methods for making the new A83543 components by culture of Saccharopolyspora spinosa NRRL 18823 are provided. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: June 16, 1998
    Assignee: Dow AgroSciences LLC
    Inventors: Jan R. Turner, Mary L.B. Huber, Mary C. Broughton, Jon S. Mynderse, James W. Martin
  • A83543 compounds and process for production thereof
    Patent number: 5670486
    Abstract: New A83543 components, including fermentation products A83543K, A83543O, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, James A. Mabe, Jan R. Turner, Mary L. B. Huber, Mary C. Broughton, Walter M. Nakatsukasa, Lawrence Creemer, Herbert A. Kirst, James W. Martin
  • A83543 compounds and process for production thereof
    Patent number: 5670364
    Abstract: New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, James A. Mabe, Jan R. Turner, Mary L. B. Huber, Mary C. Broughton, Walter M. Nakatsukasa, Lawrence Creemer, Herbert A. Kirst, James W. Martin
  • Saccharopolyspora spinosa strain
    Patent number: 5631155
    Abstract: New A83543 components, including fermentation products A83543Q, A83543R, A83543S and A83543T and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones are useful for the preparation of A83543 components. Methods for making the new A83543 components by culture of Saccharopolyspora spinosa NRRL 18823 are provided. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 1997
    Assignee: DowElanco
    Inventors: Jan R. Turner, Mary L.B. Huber, Mary C. Broughton, Jon S. Mynderse, James W. Martin
  • Process for the production of A83543 compounds with Saccharopolyspora spinosa
    Patent number: 5591606
    Abstract: New A83543 components, including fermentation products A83543Q, A83543R, A83543S and A83543T and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones are useful for the preparation of A83543 components. Methods for making the new A83543 components by culture of Saccharopolyspora spinosa NRRL 18823 are provided. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: January 7, 1997
    Assignee: DowElanco
    Inventors: Jan R. Turner, Mary L. B. Huber, Mary C. Broughton, Jon S. Mynderse, James W. Martin
  • A83543 aglycones and pseudoglycones
    Patent number: 5539089
    Abstract: A83543 Aglycones A83543AgA, A83543AgD, A83543AgE, and A83543AgF, and A83543 pseudoaglycones A83543PsaA2, A83543PsaB2, A83543PsaD2, and A83543PsaN2 are intermediates useful in preparation of known insecticides.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: July 23, 1996
    Assignee: DowElanco
    Inventors: Mary C. Broughton, Lawrence Creemer, Mary L. B. Huber, Herbert A. Kirst, Jan R. Turner
  • Activator gene for macrolide biosynthesis
    Patent number: 5514544
    Abstract: A gene encoding activator protein (srmR) for increasing transcriptional efficiency of macrolide biosynthetic genes is disclosed and claimed. Methods for using srmR to increase macrolide biosynthetic gene transcription and identifying further macrolide biosynthetic pathways are disclosed. Recombinant DNA vectors comprising the srmR gene are disclosed.
    Type: Grant
    Filed: July 26, 1991
    Date of Patent: May 7, 1996
    Assignee: Eli Lilly and Company
    Inventors: Ramachandra N. Rao, Jan R. Turner
  • A83543 compounds and processes for production thereof
    Patent number: 5202242
    Abstract: New fermentation products A83543L, A83543M, and A83543N, N-demethyl derivatives thereof, and salts thereof, are useful for the control of insects. A83543PsaL1 is useful for the preparation of A83543 components. Methods for making A83543J, A83543L, A83543M, and A83543N by culture of Saccharopolyspora spinosa NRRL 18719 or NRRL 18720 are provided. Insecticidal and ectoparasiticidal compositions containing A83543L, A83543M, A83543N, and N-demethyl derivatives thereof are also provided.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: April 13, 1993
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, James W. Martin, Jan R. Turner, Lawrence C. Creemer, Herbert A. Kirst, Mary C. Broughton, Mary L. B. Huber
  • Macrocin derivatives
    Patent number: 4656258
    Abstract: New macrocin and lactenocin ester derivatives of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; and the acid addition salts thereof; prepared by bioconversion of macrocin or lactenocin with an acylating enzyme system produced by Streptomyces thermotolerans strains, have improved activity against Mycoplasma species.
    Type: Grant
    Filed: June 11, 1985
    Date of Patent: April 7, 1987
    Assignee: Eli Lilly and Company
    Inventors: Jan R. Turner, Veronica M. Krupinski, David S. Fukuda, Richard H. Baltz
  • Methods of controlling mycoplasma infections
    Patent number: 4594337
    Abstract: Methods of controlling Mycoplasma infections which comprise administering to an infected or susceptible warm-blooded animal an effective amount of a new macrocin or lactenocin ester derivative of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; or a pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: June 10, 1986
    Assignee: Eli Lilly and Company
    Inventors: Earl E. Ose, Jan R. Turner
  • Process for preparing macrocin derivatives
    Patent number: 4559301
    Abstract: New macrocin and lactenocin ester derivatives of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; and the acid addition salts thereof; prepared by bioconversion of macrocin or lactenocin with an acylating enzyme system produced by Streptomyces thermotolerans strains, have improved activity against Mycoplasma species.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: December 17, 1985
    Assignee: Eli Lilly and Company
    Inventors: Jan R. Turner, Veronica M. Krupinski, David S. Fukuda, Richard H. Baltz
  • Method of producing antibacterial agents and bioconverting microorganism therefor
    Patent number: 4522919
    Abstract: Improved bioconverting strain of Streptomyces thermotolerans useful in preparing tylosin esters and new antibacterial macrocin or lactenocin ester derivatives of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: June 11, 1985
    Assignee: Eli Lilly and Company
    Inventors: Barbara B. Shreve, Jan R. Turner
  • Indolylglycyl cephalosporin derivatives
    Patent number: 4492694
    Abstract: 7-(3-Indolyl)glycylamido cephalosporins have good gram positive activity and favorable pharmacokinetics and are orally effective.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: January 8, 1985
    Assignee: Eli Lilly and Company
    Inventors: Larry C. Blaszczak, Jan R. Turner
  • Benzothienylglycyl cephalosporin derivatives
    Patent number: 4492693
    Abstract: 7-(3-Benzothienyl)glycylamido cephalosporins have good gram positive activity and favorable pharmacokinetics and are orally effective.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: January 8, 1985
    Assignee: Eli Lilly and Company
    Inventors: Larry C. Blaszczak, Stjepan Kukolja, Jan R. Turner