Patents by Inventor Jan Ramza

Jan Ramza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF SODIUM SALT OF 1-(((1(R)-(3-(2-(7-CHLORO-2-QUINOLINYL)-ETHENYL)PHENYL)-3-(2-(1-HYDROXY-1-METHYLETHYL)PHENYL)PROPYL)SULFANYL)METHYL)CYCLOPROPANEACETIC ACID
    Publication number: 20100069641
    Abstract: A novel process for the preparation of a sodium salt of 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methyl-ethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid, comprising: a) reacting a compound of Formula 1 with methanesulfonyl chloride in the presence of a tertiary amine to yield a crude solution of a compound of Formula 2; b) filtering the crude solution of compound of Formula 2 obtained in a) to remove solid amine hydrochloride, reacting the filtrate without isolation or further purification with a compound of Formula 3, and isolating 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid; c) reacting the 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)sulfanyl)methyl)cyclopropaneacetic acid isolated in b) with tert-butylamine to yield a compound of formula 4; d) isolating and purifying the compound of formula 4; and e) converting th
    Type: Application
    Filed: April 30, 2008
    Publication date: March 18, 2010
    Applicant: ZAKLADY FARMACEUTYCZNE POLPHARMA S.A.
    Inventors: Daniel Zyla, Robert Rynkiewicz, Mariusz Krzyzanowski, Jan Ramza
  • Novel Salt of Montelukast
    Publication number: 20090005413
    Abstract: The invention relates to a novel salt of montelukast with tert-butylamine and its use in the process for the preparation of highly pure free montelukast acid and/or pharmaceutically acceptable salts thereof, in particular montelukast sodium.
    Type: Application
    Filed: October 21, 2005
    Publication date: January 1, 2009
    Applicants: INSTYTUT FARMACEUTYCZNY, ZAKLADY FARMACEUTYCZNE POLPHARMA SA
    Inventors: Osman Achmatowicz, Krzysztof Wisniewski, Jan Ramza, Wieslaw Szelejewski, Barbara Szechner
  • AMORPHOUS CARVEDILOL PHOSPHATE AND METHOD OF MANUFACTURING THEREOF
    Publication number: 20080242872
    Abstract: The subject of the invention is amorphous carvedilol phosphate and a method of manufacturing amorphous carvedilol phosphate comprising removing solvent from carvedilol phosphate solution by means of spray drying.
    Type: Application
    Filed: October 3, 2007
    Publication date: October 2, 2008
    Applicant: ZAKLADY FARMACEUTYCZNE POLPHARMA S.A.
    Inventors: Jerzy DRYGAS, Jolanta PAWLOWSKA, Roman SZRAMKA, Jan RAMZA