Patents by Inventor Jan Reedijk
Jan Reedijk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20080221328Abstract: Neutral lanthanide(III) complexes including at least one ligand are disclosed. The ligand includes a heterocyclic aromatic ring with at least one carboxylic acid group attached thereto, wherein a heteroatom of the heterocyclic ring and the carboxylate function of the carboxylic acid group co-ordinate (chelate) to the lanthanide. The complexes can be used in luminescent lamps and luminescent displays. The complexes can be synthesized by heating a mixture of a lanthanide 3+ salt and ligand L in a suitable solvent until a precipitate of the lanthanide complex forms. In one embodiment, the formal 3+ charge on the lanthanide is neutralized by providing in the ligands for the complex, three coordinating carboxylate groups, (RCO2?). The heteroatom coordinated to the lanthanide may be nitrogen, oxygen, sulfur or phosphorus.Type: ApplicationFiled: March 3, 2008Publication date: September 11, 2008Inventors: Jan Reedijk, Wen Tian Fu, Patrick Gamez-Enamorado, Tiddo J. Mooibroek
-
Patent number: 7217813Abstract: The present invention provides a labeled nucleoside having formula: where X represents an aliphatic diamine, and the labeling moiety comprises a label and a spacer, where the spacer is coupled at one end to a platinum atom and at the other end to the label, which spacer comprises a chain having at least four carbon atoms and at least one oxygen atom in the chain. The invention further provides a method for labeling a nucleoside, kits for labeling a nucleoside, and kits for producing a labeled nucleic acid.Type: GrantFiled: September 27, 2004Date of Patent: May 15, 2007Assignee: Kreatech Biotechnology B.V.Inventors: Hendrick Jan Houthoff, Jan Reedijk, Tinka Jelsma, Robert Jochem Heetebrij, Herman Hendricus Volkers
-
Publication number: 20070080478Abstract: A protective element for a breakwater or wave-retarding construction comprises a body that has at least two opposing projections. The projections are on either side of a flat base and extend transversely thereto. The periphery of the base is non-circular, so that rolling of the protective element under the influence of the beating of the waves is resisted.Type: ApplicationFiled: December 11, 2006Publication date: April 12, 2007Applicant: HBG CIVIEL B.V.Inventors: Jan Reedijk, Martijn Klabbers, Markus Muttray
-
Publication number: 20050214075Abstract: A protective element for a breakwater or wave-retarding construction comprises a body that has at least two opposing projections. The projections are on either side of a flat base and extend transversely thereto. The periphery of the base is non-circular, so that rolling of the protective element under the influence of the beating of the waves is resisted.Type: ApplicationFiled: July 24, 2003Publication date: September 29, 2005Applicant: HBG CIVIEL B.V.Inventors: Jan Reedijk, Martijn Klabbers, Markus Muttray
-
Publication number: 20050118621Abstract: The present invention provides a labeled nucleoside having formula: where X represents an aliphatic diamine, and the labeling moiety comprises a label and a spacer, where the spacer is coupled at one end to a platinum atom and at the other end to the label, which spacer comprises a chain having at least four carbon atoms and at least one oxygen atom in the chain. The invention further provides a method for labeling a nucleoside, kits for labeling a nucleoside, and kits for producing a labeled nucleic acid.Type: ApplicationFiled: September 27, 2004Publication date: June 2, 2005Inventors: Hendrick Houthoff, Jan Reedijk, Tinka Jelsma, Robert Heetebrij, Herman Volkers
-
Patent number: 6797818Abstract: The present invention provides a labeled nucleotide having formula: where X is an aliphatic diamine, and the labeling moiety comprises a label and a spacer, where the spacer is coupled at one end to a platinum atom and at the other end to the label, which spacer comprises a chain having at least four atoms. The invention further provides a method for labeling a nucleotide, kits for labeling a nucleotide, and kits containing labeled nucleotides.Type: GrantFiled: January 14, 2002Date of Patent: September 28, 2004Assignee: Kreatech Biotechnology B.V.Inventors: Hendrick Jan Houthoff, Jan Reedijk, Tinka Jelsma, Robert Jochem Heetebrij, Herman Hendricus Volkers
-
Publication number: 20020160396Abstract: The present invention provides a labeled nucleotide having formula: 1Type: ApplicationFiled: January 14, 2002Publication date: October 31, 2002Inventors: Hendrick Jan Houthoff, Jan Reedijk, Tinka Jelsma, Robert Jochem Heetebrij, Herman Hendricus Volkers
-
Patent number: 6338943Abstract: The present invention provides improved methods for labeling nucleotides. The method of the invention for labeling nucleotides comprises the steps of: reacting a reactive moiety of a linker, which linker is a platinum compound having a stabilizing bridge and two reactive moieties, with an electron donating moiety of a spacer, which spacer comprises a chain having at least four atoms and at least one heteroatom in the chain, which spacer further comprises said electron donating moiety at one end of the chain and a reactive moiety at the other end of the chain; reacting the reactive moiety of said spacer with a label; reacting the other reactive moiety of said linker with a nucleotide. A major advantage of the invention is that all nucleotides can be labeled by the method of the invention, whereas until now the attachment of a label was mostly restricted to one or certain nucleotides.Type: GrantFiled: October 8, 1999Date of Patent: January 15, 2002Assignee: Kreatech Biotechnology B.V.Inventors: Hendrick Jan Houthoff, Jan Reedijk, Tinka Jelsma, Robert Jochem Heetebrij, Herman Hendricus Volkers
-
Patent number: 6248531Abstract: The present invention is concerned with a trans-platinum based compound for use in a method for labelling a bio-organic molecule, having formula (I), wherein A represents a reactive moiety for attachment to a label, D represents a reactive moiety for attachment to a bio-organic molecule, and X1 and X2 represent the same or different inert moieties.Type: GrantFiled: December 21, 1999Date of Patent: June 19, 2001Assignee: Kreatech Biotechnology B.V.Inventors: Hendrik-Jan Houthoff, Jan Reedijk, Herman H. Volkers, Robert Jochem Heetebrij
-
Patent number: 6133038Abstract: The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other Pt.sup.II and Pt.sup.IV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.Type: GrantFiled: August 10, 1998Date of Patent: October 17, 2000Assignee: Kreatech DiagnosticsInventors: Hendrik J. Houthoff, Jan Reedijk, Tinka Jelsma, Remco Maria Van Es, Franciscus Michiel van den Berg, Edwin Leo Mario Lempers, Marieke Johanna Bloemink
-
Patent number: 5985566Abstract: The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other Pt.sup.II and Pt.sup.IV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.Type: GrantFiled: August 12, 1997Date of Patent: November 16, 1999Assignee: Kreatech DiagnosticsInventors: Hendrik J. Houthoff, Jan Reedijk, Tinka Jelsma, Remco Maria Van Es, Franciscus Michiel van den Berg, Edwin Leo Mario Lempers, Marieke Johanna Bloemink
-
Patent number: 5714327Abstract: The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other Pt.sup.II and Pt.sup.IV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.Type: GrantFiled: June 6, 1995Date of Patent: February 3, 1998Assignee: Kreatech DiagnosticsInventors: Hendrik J. Houthoff, Jan Reedijk, Tinka Jelsma, Remco Maria Van Es, Franciscus Michiel van den Berg, Edwin Leo Marlo Lempers, Marieke Johanna Bloemink
-
Patent number: 5580990Abstract: Pt-containing compound with the formula {Pt.sup.II (w)(x)(y)(z)} or {Pt.sup.IV (u)(v)(w)(x)(y)(z)}, wherein u, v, w, x, y and z represent whether or not the same whether or not interconnected ligands, of which at least one is a leaving ligand and at least one of the remaining ligands represents a detectable marker group. According to the invention (CH.sub.3).sub.2 SO, Cl or H.sub.2 O appears to be suitable as a leaving ligand while as detectable marker group a fluorescent group merits preference and is the ligand fluorescein or tetramethyl rhodamine. A suitable Pt-containing compounds is {Pt(ethylenediamine)(Me.sub.2 SO)(fluorescein-NH(CS)-NHCH.sub.3)} (PtF). Further, the invention comprises a process for the preparation of the Pt-containing compounds, where the Pt-containing compounds are prepared in a manner known per se for analogous compounds.Type: GrantFiled: October 29, 1993Date of Patent: December 3, 1996Assignees: Stichting Klinische Research Academisch Medisch Centrum, Rijksuniversiteit LeidenInventors: Franciscus M. van den Berg, Edwin L. M. Lempers, Marieke J. Bloemink, Jan Reedijk
-
Patent number: RE40557Abstract: The present invention provides improved methods for labeling nucleotides. The method of the invention for labeling nucleotides comprises the steps of: reacting a reactive moiety of a linker, which linker is a platinum compound having a stabilizing bridge and two reactive moieties, with an electron donating moiety of a spacer, which spacer comprises a chain having at least four atoms and at least one heteroatom in the chain, which spacer further comprises said electron donating moiety at one end of the chain and a reactive moiety at the other end of the chain; reacting the reactive moiety of said spacer with a label; reacting the other reactive moiety of said linker with a nucleotide. A major advantage of the invention is that all nucleotides can be labeled by the method of the invention, whereas until now the attachment of a label was mostly restricted to one or certain nucleotides.Type: GrantFiled: October 8, 1997Date of Patent: October 28, 2008Assignee: Kreatech Biotechnology B.V.Inventors: Jan Hendrick Houthoff, Jan Reedijk, Tinka Jelsma, Robert Jochem Heetebrij, Herman Hendricus Volkers