Patents by Inventor Jan S. Tkacz

Jan S. Tkacz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Maxi-k channel blockers, methods of use and process for making the same
    Patent number: 7294646
    Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: November 13, 2007
    Assignee: Merck & Co. Inc.
    Inventors: Maria L. Garcia, Michael A. Goetz, Gregory J. Kaczorowski, Owen B. McManus, Richard L. Monaghan, William R. Strohl, Jan S. Tkacz
  • Process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
    Patent number: 5684128
    Abstract: An improved process for the preparation of side chain derivatives of cyclohexapeptidyl lipopeptides represented by the formula ##STR1## wherein R.sup.1 is fully defined, is disclosed.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: November 4, 1997
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski, Akinlolu A. Adefarati, Jan S. Tkacz
  • Process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
    Patent number: 5646245
    Abstract: An improved process for the preparation of side chain derivatives of cyclohexapeptidyl lipopeptides represented by the formula ##STR1## wherein R.sup.1 is fully defined, is disclosed.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: July 8, 1997
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski, Akinlolu A. Adefarati, Jan S. Tkacz
  • Cyclohexapeptide compound
    Patent number: 5310873
    Abstract: A cyclohexapeptide base which is the nucleus of closely related antibiotics obtained by culturing Zalerion arboricola and its salts are described. They are useful intermediates for the preparation of new semisynthetic compounds having antimicrobial activity.
    Type: Grant
    Filed: March 12, 1990
    Date of Patent: May 10, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Dennis M. Schmatz, Jan S. Tkacz, Robert E. Schwartz, Mervyn Turner
  • Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
    Patent number: 5021341
    Abstract: An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity and its production and isolation are described.
    Type: Grant
    Filed: March 12, 1990
    Date of Patent: June 4, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Giacobbe, Jan S. Tkacz, Prakash S. Masurekar, Louis Kaplan, Margaret S. Sosa