Patents by Inventor Jan Sap

Jan Sap has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel receptor-type phosphotyrosine phosphatase-alpha
    Publication number: 20050037380
    Abstract: A novel receptor-type protein tyrosine phosphatase (RPTP) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of proteins are human RPTP?, human RPTP? and human RPTP?. The RPTP protein or glycoprotein may be produced by recombinant means. Antibodies to the proteins, methods for measuring the quantity of the proteins, methods for screening compounds, such as drugs, which can bind to the proteins and inhibit or stimulate their activity, are provided.
    Type: Application
    Filed: February 13, 2004
    Publication date: February 17, 2005
    Inventors: Joseph Schlessinger, Jan Sap
  • Novel receptor-type phosphotyrosine phosphatase-alpha
    Publication number: 20050036999
    Abstract: A novel receptor-type protein tyrosine phosphatase (RPTP) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of proteins are human RPTP?, human RPTP? and human RPTP?. The RPTP protein or glycoprotein may be produced by recombinant means. Antibodies to the proteins, methods for measuring the quantity of the proteins, methods for screening compounds, such as drugs, which can bind to the proteins and inhibit or stimulate their activity, are provided.
    Type: Application
    Filed: February 13, 2004
    Publication date: February 17, 2005
    Inventors: Joseph Schlessinger, Jan Sap
  • Novel receptor-type phosphotyrosine phosphatase-alpha
    Publication number: 20050032087
    Abstract: A novel receptor-type protein tyrosine phosphatase (RPTP) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of proteins are human RPTP?, human RPTP? and human RPTP?. The RPTP protein or glycoprotein may be produced by recombinant means. Antibodies to the proteins, methods for measuring the quantity of the proteins, methods for screening compounds, such as drugs, which can bind to the proteins and inhibit or stimulate their activity, are provided.
    Type: Application
    Filed: February 13, 2004
    Publication date: February 10, 2005
    Inventors: Joseph Schlessinger, Jan Sap
  • Treatment of diabetes mellitus and insulin receptor signal transduction
    Publication number: 20030091551
    Abstract: The present invention relates to novel modalities of treatment of diabetes, and other diseases caused by dysfunctional signal transduction by insulin receptor type tyrosine kinases (IR-PTK). Applicants discovered that IR-PTK activity may be modified by modulating the activity of a tyrosine phosphatase, and IR-PTK signal transduction may be triggered even in the absence of ligand. Methods for identifying compounds that, by modulating RPTP&agr; or RPTP&egr; activity, elicit or modulate insulin receptor signal transduction are also described.
    Type: Application
    Filed: October 11, 2002
    Publication date: May 15, 2003
    Applicant: New York University/Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.v.
    Inventors: Axel Ullrich, Reiner Lammers, Alexei Kharitonnenkov, Jan Sap, Joseph Schlessinger
  • Treatment of diabetes mellitus and insulin receptor signal transduction
    Publication number: 20020022023
    Abstract: The present invention relates to novel modalities of treatment of diabetes, and other diseases caused by dysfunctional signal transduction by insulin receptor type tyrosine kinases (IR-PTK). Applicants discovered that IR-PTK activity may be modified by modulating the activity of a tyrosine phosphatase, and IR-PTK signal transduction may be triggered even in the absence of ligand. Methods for identifying compounds that, by modulating RPTP&agr; or RPTP&egr; activity, elicit or modulate insulin receptor signal transduction are also described.
    Type: Application
    Filed: March 19, 2001
    Publication date: February 21, 2002
    Inventors: Axel Ullrich, Reiner Lammers, Alexei Kharitonnenkov, Jan Sap, Joseph Schlessinger