Abstract: A process for the preparation of 5-substituted 4-amino-2-methylpyrimidines of the formula wherein R is CONH2 or CN, and of acid addition salts thereof, characterized in that a compound of formula H2N—CH?C(R) CN (II) is reacted with acetimidic acid methyl ester or an acid addition salt thereof and that, if desired, a compound of formula I is transferred into an acid addition salt, and the transformation of a compound of formula II wherein R is CONH2 into a compound of formula II wherein R is CN by treatment with POCl3.

Abstract: A process for the preparation of 5-substituted 4-amino-2-methylpyrimidines of the formula wherein R is CONH2 or CN, and of acid addition salts thereof, characterized in that a compound of formula H2N—CH?C(R) CN (II) is reacted with acetimidic acid methyl ester or an acid addition salt thereof and that, if desired, a compound of formula I is transferred into an acid addition salt, and the transformation of a compound of formula II wherein R is CONH2 into a compound of formula II wherein R is CN by treatment with POCl3.

Abstract: Described is the use of a nucleic acid molecule encoding an IL-12 polypeptide for the preparation of a pharmaceutical composition for the treatment of a tumor, wherein the pharmaceutical composition is for intra-tumoral administration.

Abstract: Described is the use of a nucleic acid molecule encoding an IL-12 polypeptide for the preparation of a pharmaceutical composition for the treatment of a tumor, wherein the pharmaceutical composition is for intra-tumoral administration.

Abstract: A system for analyzing the balance of a golfer during a golf swing and to determine weight shifts from one foot to the other and between the heel and toe of each foot during a golf swing. Basically the system comprises two foot pads capable of measuring weight on each pad and on the front and rear portions of each pad, a display for displaying weight information in digital and/or graphical form, a sound sensor for sensing the impact of a golf club against a golf ball and a microprocessor system for receiving information from the pads and generating the display. In use, a golfer positions the foot pads where his feet would be in his normal golf stance, arranges the display in front of the pads a safe distance away, positions the cable between footpads and display out of the way and places a normal golf ball on a tee or on the ground the appropriate distance from the footpads. The unit is turned on and parameters are set, the golfer stands on the footpads and then takes his normal swing at the golf ball.