Patents by Inventor Jan Simoni

Jan Simoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic compositions for viral-associated disease states and methods of making and using same
    Patent number: 9669151
    Abstract: A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: June 6, 2017
    Assignee: IMMUTRIX THERAPEUTICS, INC.
    Inventors: Carol A. Rae, Jan Simoni, Grace Simoni, John F. Moeller
  • Therapeutic Compositions for Viral-Associated Disease States and Methods of Making and Using Same
    Publication number: 20150297821
    Abstract: A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
    Type: Application
    Filed: March 9, 2015
    Publication date: October 22, 2015
    Inventors: Carol A. Rae, Jan Simoni, Grace Simoni, John F. Moeller
  • Methods of treating acute blood loss
    Publication number: 20070270333
    Abstract: The present invention relates to novel methods of using blood substitutes to treat acute blood loss and novel pharmaceutical compositions comprising blood substitutes. Blood substitutes useful for the methods of the present invention can (1) induce expression of erythropoietin as tested in a cell culture under normoxic conditions, and/or (2) induce erythropoiesis under normoxic conditions as measured by (a) a decrease in the doubling time of the subject's hematocrit or hemoglobin, and/or (b) an increase in the subject's circulating erythropoietin level. Blood substitutes useful for the pharmaceutical compositions of the present invention can (1) stabilize HIF-1 alpha expression, and/or (2) down regulate NF-kappa B.
    Type: Application
    Filed: May 16, 2006
    Publication date: November 22, 2007
    Inventors: Jan Simoni, Grace Simoni, Mario Feola