Abstract: The invention provides compositions and methods for determining the increased risk for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprising determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

Abstract: The invention provides compositions and methods for determining the increased risk for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprising determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

Abstract: The invention provides compositions and methods for determining the increased risk for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprising determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

Abstract: The invention provides compositions and methods for determining the increased risks for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprising determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

Abstract: The invention provides compositions and methods for determining the increased risks for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprising determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

Abstract: The present invention discloses a novel single nucleotide polymorphism (SNP) in the isolated 5? tandem repeats of the thymidylate synthase (TS) gene and methods for its use. The novel SNP, located in the 12th nucleotide of a 28 bp third tandem repeat (3R) of the TS gene, substitutes a C for a G, and is the variant form of the repeat. Subjects with the wild-type form of 3R have greater transcription of the TS gene than subjects with the variant form. The invention also reveals that a six base pair deletion in the 3? region of TS (?6 bp/1494) indicates mRNA instability and thus reduced production of TS. In diseased tissue, such as cancer, reduced production of TS is beneficial because it prevents the cancerous cells from growing and spreading. Analysis of either polymorphism or both together allows for prediction of a subject's response to chemotherapeutic and anti-cardiovascular disease treatments because both diseases are related to TS levels in a subject.

Abstract: The invention provides a method for determining the colorectal cancer susceptibility of a patient comprising determining a patient's genotype at the manganese superoxide dismutase (MnSOD) gene locus, wherein a patient with one or two alleles encoding alanine at position −9 of the signal peptide has an increased risk of developing colorectal cancer. Also provided are nucleic acid probes and kits for determining a patient's colorectal cancer risk.

Abstract: The invention provides a method for determining the colorectal cancer susceptibility of a patient comprising determining a patient's genotype at the manganese superoxide dismutase (MnSOD) gene locus, wherein a patient with one or two alleles encoding alanine at position −9 of the signal peptide has an increased risk of developing colorectal cancer. Also provided are nucleic acid probes and kits for determining a patient's colorectal cancer risk.

Abstract: The invention provides a method for determining the colorectal cancer susceptibility of a patient comprising determining a patient's genotype at the manganese superoxide dismutase (MnSOD) gene locus, wherein a patient with one or two alleles encoding alanine at position −9 of the signal peptide has an increased risk of developing colorectal cancer. Also provided are nucleic acid probes and kits for determining a patient's colorectal cancer risk.