Patents by Inventor Jan ter Wiel

Jan ter Wiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6503723
    Abstract: The invention provides a method for detecting ATP in a sample, wherein the sample is contacted with a reaction mixture to effect a light signal, the reaction mixture comprising luciferin, luciferase and one or more water-soluble salts, the total salt concentration being at least 0.05 mole/liter, and wherein the light signal is measured. A kit is described for detecting ATP in a sample comprising luciferin, luciferase and a buffer solution comprising salts. A composition for detecting ATP in a sample comprising a total salt concentration of at least 0.05 mole/liter for prolonging a light signal occurring in a luciferin-luciferase reaction is also provided.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: January 7, 2003
    Assignee: Packard Bioscience B.V.
    Inventors: Harry van Lune, Jan ter Wiel
  • Patent number: 5512753
    Abstract: A scintillation counting system utilizing scintillator capsules for the detection of radioactive substances in a sample for analysis include a liquid scintillator core encapsulated within a shell. The liquid scintillator comprises a base component or components and one or more fluors. The base component preferably includes one or more aromatic solvents. The fluors useful in the liquid or gel scintillator include any of the organic fluors well-known in the scintillation counting art. The liquid or gel scintillator can also include a wavelength shifter (i.e. secondary fluors). Useful wavelength shifters are also well known in the scintillation counting art. Additionally, a other materials can be added to the scintillator capsules to modify the characteristics of the scintillator capsules, and the scintillator capsules can be used in a variety of scintillation counting applications.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: April 30, 1996
    Assignee: Packard Instrument, B.V.
    Inventors: James Thomson, Jan ter Wiel, Harry van Lune, Herbert M. Bosel, Gerhard H. Kremer
  • Patent number: 5410155
    Abstract: A liquid scintillation medium for homogeneous flow systems which comprises solvent, fluor and optionally surfactant, wherein the solvent comprises benzyltoluene. The solvent may comprise the positional isomers of benzyltoluene, and other solvents such as diphenylethane. This new solvent system for use in flow-through scintillation counting is characterized by low viscosity, high flash point and low vapour pressure.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: April 25, 1995
    Assignee: Packard Instrument, B.V.
    Inventors: James Thomson, Jan ter Wiel
  • Patent number: 4624799
    Abstract: A liquid, homogeneous mixture for use in the LSC (Liquid Scintillation Counting) analysis technique, comprising a scintillation liquid, a scintillator and a surfactant, wherein the surfactant includes one or more phosphoric acid esters having formula 1 and/or formula 2 of the sheet of formulae, in which R', R" and R'" represent an organic group, which phosphor acid esters are neutralized to a pH, at which the neutralization product comprises a mono- and/or diphosphate with an alkaline material having a pK.sub.a of at least 5, and in which of the organic phosphoric acid esters having formula 1, R" and R'" may be the same or different.
    Type: Grant
    Filed: September 14, 1984
    Date of Patent: November 25, 1986
    Assignee: Packard Instrument B.V.
    Inventors: Theodorus C. J. M. Hegge, Jan ter Wiel