Patents by Inventor Jan Torzewski

Jan Torzewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF INTERLEUKIN 10 MRNA TRANSFECTED MACROPHAGES IN ANTI-INFLAMMATORY THERAPIES
    Publication number: 20160206699
    Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.
    Type: Application
    Filed: March 15, 2016
    Publication date: July 21, 2016
    Applicants: Ruprecht-Karls-Universität Heidelberg, Universität Ulm
    Inventors: Ziya KAYA, Hugo KATUS, Oliver ZIMMERMANN, Wolfgang ROTTBAUER, Jan TORZEWSKI
  • Use of interleukin 10 mRNA transfected macrophages in anti-inflammatory therapies
    Patent number: 9315558
    Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: April 19, 2016
    Assignees: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, UNIVERSITÄT ULM
    Inventors: Ziya Kaya, Hugo Katus, Oliver Zimmermann, Wolfgang Rottbauer, Jan Torzewski
  • USE OF INTERLEUKIN 10 MRNA TRANSFECTED MACROPHAGES IN ANTI-INFLAMMATORY THERAPIES
    Publication number: 20130303596
    Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.
    Type: Application
    Filed: November 14, 2011
    Publication date: November 14, 2013
    Applicants: UNIVERSITAT ULM, RUPRECHT-LARLS-UNIVERSITAT- HEIDELBERG
    Inventors: Ziya Kaya, Hugo Katus, Oliver Zimmermann, Wolfgang Rottbauer, Jan Torzewski
  • mRNA-TRANSFECTION OF ADULT PROGENITOR CELLS FOR SPECIFIC TISSUE REGENERATION
    Publication number: 20110104127
    Abstract: The present invention relates to progenitor cells, medicaments containing progenitor cells and also uses thereof for specific tissue regeneration. Such processes are required in all medical sectors, in particular in the treatment of cardiovascular, haematological, nephrological, neurological, dermatological, gastroenterological or orthopaedic disorders. The progenitor cells are characterized in that they are transfected with mRNA which codes for a protein which promotes colonization of the progenitor cells in a target tissue and/or the differentiation of the progenitor cells in target cells or target tissue cells.
    Type: Application
    Filed: February 8, 2007
    Publication date: May 5, 2011
    Applicant: UNIVERSITAT ULM
    Inventors: Jan Torzewski, Vinzenz Hombach, Juliane Ingeborg Marie Wiehe, Jochen Greiner, Michael Schmitt, Markus Wiesneth, Oliver Zimmermann, Hubert Schrezenmeier