Patents by Inventor Jan Trka

Jan Trka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEANS AND METHODS FOR ACCURATELY ASSESSING CLONAL IMMUNOGLOBULIN (IG)/T CELL RECEPTOR (TR) GENE REARRANGEMENTS
    Publication number: 20240018596
    Abstract: The invention relates to means and methods for assessing clonal immunoglobulin (IG)/T cell receptor (TR) gene rearrangements in a clinical, diagnostic and/or research setting. Provided is a quality control composition comprising a mixture of genomic DNA isolated from a set of nine cultured cell lines, said set comprising the B cell lines ALL/MIK (ALL), Raji (Burkitt lymphoma), REH (B cell precursor ALL), TMM (CML-BC/EBV+B-LCL), TOM-1 (B cell precursor ALL), WSU-NHL (B cell lymphoma) and the T cell lines JB6 (ALCL), Karpas299 (ALCL) and MOLT-13 (ALL), or wherein one or more cell lines of said set is replaced with one or more other cell line(s) comprising the same IG/TR gene rearrangements. Also provided is a quality control composition consisting of essentially equimolar amounts of genomic DNA isolated from healthy human thymus, healthy human tonsil and healthy human peripheral blood mononuclear cells.
    Type: Application
    Filed: March 18, 2020
    Publication date: January 18, 2024
    Inventors: Monika Ursula Helga Brüggemann, Michaela Kotrová, Henrik Knecht, Nikolaos Darzentas, Giovanni Cazzaniga, Frédéric Bernard Louis Davi, Jacobus Johannes Maria Van Dongen, Ramón Garcia-Sanz, David Gonzalez De Castro, Patricia Johanna Theodore Groenen, Michael Andreas Hummel, Elizabeth Anne Macintyre-Davi, Konstantinos Stamatopoulos, Christiane Pott, Jan Trka, Anthonie Willem Langerak