Patents by Inventor Jan van de Winkel

Jan van de Winkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human monoclonal antibodies to FC gamma receptor II (CD32)
    Publication number: 20070253958
    Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to CD32 with high affinity and have particular functional properties, such as inhibiting ligand binding, down-modulating surface expression of CD32 or specifically binding to the Fc?RIIa-H131 allotype but not the Fc?RIIa-R131 allotype. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules, vaccine conjugates and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting CD32, in particular for detecting the Fc?RIIa-H131 allotype, methods of treatment using the antibodies of the invention, such as methods for treating autoimmune hemolytic anemia, and methods for enhancing antigen presentation using the antibodies of the invention.
    Type: Application
    Filed: March 30, 2007
    Publication date: November 1, 2007
    Applicant: MEDAREX, INC.
    Inventors: Jan Van De Winkel, Marcus Van Dijk, Arnout Gerritsen
  • Antibodies against IL-13 receptor alpha1 and uses thereof
    Publication number: 20060263356
    Abstract: An antibody binding to IL-13R?1, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of said antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9 is useful in the treatment of asthma and allergic diseases.
    Type: Application
    Filed: January 3, 2006
    Publication date: November 23, 2006
    Inventors: Josef Endl, Maria Fuentes, Yvo Graus, Adelbert Grossmann, Sebastian Neumann, Paul Parren, Frank Rebers, Joerg Regula, Ralf Schumacher, Stefan Seeber, Jan stracke, Kay-Gunnar Stubenrauch, Jan Van De Winkel, Martine Van Vugt, Sandra Vereecken-Verploegen
  • Anti-P-selectin antibodies
    Publication number: 20050226876
    Abstract: This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
    Type: Application
    Filed: April 8, 2005
    Publication date: October 13, 2005
    Inventors: Yvo Graus, Jacques Himber, Miranda Jansen-Molenaar, Dorothee Kling, Erhard Kopetzki, Paul Parren, Frank Rebers, Beat Steiner, Anne Stern, Pamela Strein, Kay-Gunnar Stubenrauch, Jan van de Winkel, Martine van Vugt
  • Antibodies against insulin-like growth factor 1 receptor and uses thereof
    Publication number: 20050008642
    Abstract: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
    Type: Application
    Filed: July 8, 2004
    Publication date: January 13, 2005
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vugt
  • Antibodies against insulin-like growth factor 1 receptor and uses thereof
    Publication number: 20040228859
    Abstract: Antibodies which bind to IGF-IR and inhibit the binding of IGF-I and IGF-II to IGF-IR are characterized. These antibodies are implicated in anti-tumor therapy.
    Type: Application
    Filed: April 1, 2004
    Publication date: November 18, 2004
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vriesema-van Vugt