Patents by Inventor Jan Van Humbeeck
Jan Van Humbeeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8790697Abstract: The invention provides a controlled release delivery system comprising a bio-active compound and a matrix carrier, wherein said matrix carrier is an amorphous microporous non-fibrous silicon or titanium oxide being loaded with said bio-active compound and wherein the micropores of said matrix carrier have a mean size in the range of 0.4 to 2.0 nm.Type: GrantFiled: September 9, 2005Date of Patent: July 29, 2014Assignee: K.U. Leuven Research & DevelopmentInventors: Johan Martens, Guy Van Den Mooter, Jan Van Humbeeck, Caroline Aerts, Randy Mellaerts
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Patent number: 8663317Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.Type: GrantFiled: September 14, 2012Date of Patent: March 4, 2014Assignee: Boston Scientific Scimed, Inc.Inventors: Ivan De Scheerder, Jurgen Sohier, Natasja van der Leden, Jan Van Humbeeck
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Patent number: 8512734Abstract: A coated implantable medical device is described, wherein the coating comprises a coating matrix and particles of one or more molecular sieves, preferably zeolite of zeogrid particles, optionally loaded with one or more bioactive agents. The coating matrix itself can function as a second drug-carrying interface. The coating comprising the molecular sieve material has an excellent biocompatibility and allows suitable drug delivery into the body of an animal, preferably a mammal and most preferably a human.Type: GrantFiled: July 5, 2005Date of Patent: August 20, 2013Assignee: Katholieke Universiteit Leuven, K.U.Leuven R&DInventors: Johan Martens, Jan Van Humbeeck, Ivan De Scheerder
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Publication number: 20130004650Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.Type: ApplicationFiled: September 14, 2012Publication date: January 3, 2013Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Ivan De Scheerder, Jûrgen Sohier, Natasja van der Leden, Jan Van Humbeeck
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Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs
Patent number: 8273371Abstract: The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.Type: GrantFiled: July 6, 2009Date of Patent: September 25, 2012Inventors: Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck -
Patent number: 8267991Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.Type: GrantFiled: March 1, 2010Date of Patent: September 18, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Ivan De Scheerder, Jurgen Sohier, Natasja van der Leden, Jan Van Humbeeck
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CRYSTALLINE MESOPOROUS OXIDE BASED MATERIALS USEFUL FOR THE FIXATION AND CONTROLLED RELEASE OF DRUGS
Publication number: 20110086099Abstract: The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.Type: ApplicationFiled: July 6, 2009Publication date: April 14, 2011Applicant: K.U. Leuven Research & DevelopmentInventors: Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck -
Patent number: 7789907Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.Type: GrantFiled: February 14, 2006Date of Patent: September 7, 2010Assignee: Boston Scientific Scimed, Inc.Inventors: Ivan De Scheerder, Jurgen Sohier, Natasja van der Leden, Jan Van Humbeeck
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Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs
Patent number: 7749521Abstract: The invention describes a new class of crystalline silica material having two levels or porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.Type: GrantFiled: June 28, 2004Date of Patent: July 6, 2010Assignee: K.U. Leuven Research & DevelopmentInventors: Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck -
Publication number: 20100152836Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.Type: ApplicationFiled: March 1, 2010Publication date: June 17, 2010Applicant: Boston Scientific Scimed, Inc.Inventors: Ivan De Scheerder, Jurgen Sohier, Natasja van der Leden, Jan Van Humbeeck
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CRYSTALLINE MESOPOROUS OXIDE BASED MATERIALS USEFUL FOR THE FIXATION AND CONTROLLED RELEASE OF DRUGS
Publication number: 20100008990Abstract: The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.Type: ApplicationFiled: July 6, 2009Publication date: January 14, 2010Applicant: K.U. Leuven Research & DevelopmentInventors: Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck -
Publication number: 20080003256Abstract: A coated implantable medical device is described, wherein the coating comprises a coating matrix and particles of one or more molecular sieves, preferably zeolite of zeogrid particles, optionally loaded with one or more bioactive agents. The coating matrix itself can function as a second drug-carrying interface. The coating comprising the molecular sieve material has an excellent biocompatibility and allows suitable drug delivery into the body of an animal, preferably a mammal and most preferably a human.Type: ApplicationFiled: July 5, 2005Publication date: January 3, 2008Inventors: Johan Martens, Jan Van Humbeeck, Ivan De Scheerder
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Publication number: 20070275068Abstract: The invention provides a controlled release delivery system comprising a bio-active compound and a matrix carrier, wherein said matrix carrier is an amorphous microporous non-fibrous silicon or titanium oxide being loaded with said bio-active compound and wherein the micropores of said matrix carrier have a mean size in the range of 0.4 to 2.0 nm.Type: ApplicationFiled: September 9, 2005Publication date: November 29, 2007Inventors: Johan Martens, Guy Van Den Mooter, Jan Van Humbeeck, Caroline Aerts, Randy Mellaerts
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Patent number: 7135039Abstract: The radially expandable prosthesis for implantation in a lumen comprises a tubular wall produced from sheet metal and showing cuts enabling the prosthesis to expand. By using water guided laser cutting technology to make these cuts and/or specific electrochemical polishing technology a more biocompatible prosthesis is obtained, causing less thrombogenicity and less foreign body reaction. By covering an intraluminal prosthesis with a titaniumnitride coating the biocompatibility of the prosthesis is improved. By applying perforating or non-perforating holes (4) and filling these holes with a therapeutic agent, the intraluminal prosthesis can be used to locally administer medicines, genes and or other substances to prevent in this way thrombotic occlusions and/or neointimal hyperplasia and prosthesis narrowing. Using this specific perforated prosthesis design the total drug capacity can be increased and also the drug release time prolongs significantly.Type: GrantFiled: March 6, 2001Date of Patent: November 14, 2006Assignee: Boston Scientific Scimed, Inc.Inventors: Ivan De Scheerder, Jürgen Sohier, Natasja van der Leden, Jan Van Humbeeck
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Publication number: 20060129231Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.Type: ApplicationFiled: February 14, 2006Publication date: June 15, 2006Applicant: Boston Scientific Scimed, Inc.Inventors: Ivan De Scheerder, Jurgen Sohier, Natasja van der Leden, Jan Van Humbeeck