Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: A digital printing process for printing an image (I) including a white area (W) and/or a coloured area (C) on a packaging material includes selecting a packaging material with a substantially white side, and preparing print data to be sent to a printing means taking into account that the side of the packaging material is substantially white. The print data represents one or more first image areas (A1) representing the image (I), and one or more second image areas (A2) representing a packaging look (L), to be printed on the substantially white side of the packaging material, outside the one or more first image areas (A1) where the image (I) is to be located. The method further includes printing by the printing means on the substantially white side of the packaging material using the print data.

Abstract: A method for printing a plurality of scan lines with one or more inkjet heads includes receiving at least one scanline; creating, from pixels of said at least one scanline, a plurality of bundles of a predetermined size comprising first bundles and consecutive bundles, said first and consecutive bundles comprising pixels for which nozzles of the one or more inkjet heads have to be fired within a first time period and within a consecutive time period, respectively; and storing said plurality of bundles in a first memory. The method includes transferring said plurality of bundles from first memory to second memory; and repeating until all said pixels are available in the second memory as the first bundles. Nozzles of the one or more inkjet heads are fired in accordance with the first bundles within the first time period and steps repeated for consecutive bundles and associated respective consecutive time periods.

Abstract: A method for printing at least a first and a later print job includes receiving a first print job containing first image data of one or more first images to be printed in a printable area and a later print job containing later image data associated with a colour, determining a first sub-area of said printable area where no image of the first images is to be printed, using the first image data; printing the one or more first images in the printable area and at least one first control patch in the first sub-area, using for said at least one first control patch at least one colour representative for the colour associated with the later image data, measuring the colour of the printed at least one first control patch, and using the measured colour of the at least one first control patch for controlling the later print job.

Abstract: A digital printing process for printing an image (I) including a white area (W) and/or a coloured area (C) on a packaging material includes selecting a packaging material with a substantially white side, and preparing print data to be sent to a printing means taking into account that the side of the packaging material is substantially white. The print data represents one or more first image areas (A1) representing the image (I), and one or more second image areas (A2) representing a packaging look (L), to be printed on the substantially white side of the packaging material, outside the one or more first image areas (A1) where the image (I) is to be located. The method further includes printing by the printing means on the substantially white side of the packaging material using the print data.

Abstract: A method for printing at least a first and a later print job includes receiving a first print job containing first image data of one or more first images to be printed in a printable area and a later print job containing later image data associated with a colour, determining a first sub-area of said printable area where no image of the first images is to be printed, using the first image data; printing the one or more first images in the printable area and at least one first control patch in the first sub-area, using for said at least one first control patch at least one colour representative for the colour associated with the later image data, measuring the colour of the printed at least one first control patch, and using the measured colour of the at least one first control patch for controlling the later print job.

Abstract: A robotic system is provided for assisting during bone surgery, adapted to control the position of a limb. The robotic system includes a robotic arm connected to a fixation device for rigidly connecting the distal bone to the robotic arm and allowing movement in six degrees of freedom. Specifically, the fixation device provides at least two fixation points to the distal bone. The first fixation point can be rigidly connected to the distal bone near the joint and the second fixation point can be rigidly connected to a distal position of the distal bone. The rigid connection of the distal bone to the robotic arm allows the robotic system to impose controlled movement on the distal bone in six degrees of freedom.

Abstract: Knee prostheses that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or accommodating internal tibial rotation, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a natural way. Such prostheses may include an insert component disposed between a femoral component and a tibial component, the insert component featuring, among other things, a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes. Other surfaces can be shaped using iterative automated techniques that allow testing and iterative design taking into account a manageable set of major forces acting on the knee during normal functioning, together with information that is known about natural knee joint kinetics and kinematics.

Abstract: A method for printing with an inkjet head includes: printing with an inkjet head comprising a plurality n of parallel nozzle rows, where n is at least 2; where each nozzle row comprises a plurality of nozzles, where adjacent nozzle rows of the plurality of nozzle rows are shifted with respect to each other; where a distance between two nozzle rows, seen in the printing direction, is d; and where said printing includes: moving the substrate with respect to the inkjet head in the printing direction at a printing speed v?; and firing each nozzle of the plurality of nozzles with a firing frequency f?; where the plurality of nozzle rows are fired at different instants in time, such that the distance d? between printed rows of dots printed by the two nozzle rows, seen in the printing direction, is larger or smaller than d.

Abstract: A method for printing with an inkjet head includes: printing with an inkjet head comprising a plurality n of parallel nozzle rows, where n is at least 2; where each nozzle row comprises a plurality of nozzles, where adjacent nozzle rows of the plurality of nozzle rows are shifted with respect to each other; where a distance between two nozzle rows, seen in the printing direction, is d; and where said printing includes: moving the substrate with respect to the inkjet head in the printing direction at a printing speed v?; and firing each nozzle of the plurality of nozzles with a firing frequency f?; where the plurality of nozzle rows are fired at different instants in time, such that the distance d? between printed rows of dots printed by the two nozzle rows, seen in the printing direction, is larger or smaller than d.

Abstract: A method for printing a plurality of scan lines with one or more inkjet heads includes receiving at least one scanline; creating, from pixels of said at least one scanline, a plurality of bundles of a predetermined size comprising first bundles and consecutive bundles, said first and consecutive bundles comprising pixels for which nozzles of the one or more inkjet heads have to be fired within a first time period and within a consecutive time period, respectively; and storing said plurality of bundles in a first memory. The method includes transferring said plurality of bundles from first memory to second memory; and repeating until all said pixels are available in the second memory as the first bundles. Nozzles of the one or more inkjet heads are fired in accordance with the first bundles within the first time period and steps repeated for consecutive bundles and associated respective consecutive time periods.

Abstract: Knee prostheses that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or accommodating internal tibial rotation, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a natural way. Such prostheses may include an insert component disposed between a femoral component and a tibial component, the insert component featuring, among other things, a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes. Other surfaces can be shaped using iterative automated techniques that allow testing and iterative design taking into account a manageable set of major forces acting on the knee during normal functioning, together with information that is known about natural knee joint kinetics and kinematics.

Abstract: Knee prostheses that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or accommodating internal tibial rotation, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a natural way. Such prostheses may include an insert component disposed between a femoral component and a tibial component, the insert component featuring, among other things, a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes. Other surfaces can be shaped using iterative automated techniques that allow testing and iterative design taking into account a manageable set of major forces acting on the knee during normal functioning, together with information that is known about natural knee joint kinetics and kinematics.

Abstract: This tibial implant (2) comprises a tibial base (3) intended to be fastened to a resected proximal end of a tibia of a patient, the tibial base (3) comprising a medial bearing portion (7) and a lateral bearing portion (8); and a tibial insert (4) shaped to be mounted on the tibial base (3), the tibial insert (4) comprising a medial insert portion (17) including a concave medial bearing surface (18) intended to cooperate with a medial condyle of a femoral component or of a femur, and a lateral insert portion (19) including a concave lateral bearing surface (21) intended to cooperate with a lateral condyle of the femoral component or of the femur. The lateral insert portion (19) has, at its postero-lateral edge (24), an insert notch (26) for the passage of the tendon of the popliteus, and/or the lateral bearing portion (8) has, at its postero-lateral edge (12), a base notch (13) for the passage of the tendon of the popliteus.

Abstract: A digital printing apparatus using liquid toner including a carrier liquid, a dispersing agent and imaging particles. The apparatus includes a first image forming unit for a first colour; a second image forming unit for a second colour, and a substrate support assembly for supporting the substrate during the subsequent transfer of first and second liquid toner from the first and second image forming unit to the substrate. The second image forming unit is arranged downstream of the first image forming unit along the substrate support assembly. The first image forming unit and the substrate support assembly are arranged such that the substrate is compressed in a first nip between the first image forming unit and the substrate support assembly. A control mechanism adjusts the first and/or second pattern to compensate for the increased width of the substrate downstream of the first image forming unit.

Abstract: Knee prostheses featuring components that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or at least accommodating internal tibial rotation in a controlled way, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a more natural way. In a preferred embodiment, such prostheses include an insert component disposed between a femoral component and a tibial component, the insert component preferably featuring among other things a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes.

Abstract: Knee prostheses that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or accommodating internal tibial rotation, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a natural way. Such prostheses may include an insert component disposed between a femoral component and a tibial component, the insert component featuring, among other things, a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes. Other surfaces can be shaped using iterative automated techniques that allow testing and iterative design taking into account a manageable set of major forces acting on the knee during normal functioning, together with information that is known about natural knee joint kinetics and kinematics.

Abstract: This tibial implant (2) comprises a tibial base (3) intended to be fastened to a resected proximal end of a tibia of a patient, the tibial base (3) comprising a medial bearing portion (7) and a lateral bearing portion (8); and a tibial insert (4) shaped to be mounted on the tibial base (3), the tibial insert (4) comprising a medial insert portion (17) including a concave medial bearing surface (18) intended to cooperate with a medial condyle of a femoral component or of a femur, and a lateral insert portion (19) including a concave lateral bearing surface (21) intended to cooperate with a lateral condyle of the femoral component or of the femur. The lateral insert portion (19) has, at its postero-lateral edge (24), an insert notch (26) for the passage of the tendon of the popliteus, and/or the lateral bearing portion (8) has, at its postero-lateral edge (12), a base notch (13) for the passage of the tendon of the popliteus.

Abstract: Knee prostheses featuring components that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or at least accommodating internal tibial rotation in a controlled way, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a more natural way. In a preferred embodiment, such prostheses include an insert component disposed between a femoral component and a tibial component, the insert component preferably featuring among other things a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes.

Abstract: Knee prostheses featuring components that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or at least accommodating internal tibial rotation in a controlled way, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a more natural way. In a preferred embodiment, such prostheses include an insert component disposed between a femoral component and a tibial component, the insert component preferably featuring among other things a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes.