Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.

Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.

Abstract: The present invention relates to the provision of novel centrifuge activated assembly that can be used for reconstitution of dry formulations on addition of diluent and to pharmaceutical or veterinary products suitable for parenteral administration that have been prepared with or in the devices according to the novel method of the invention.

Abstract: The present invention relates to maintaining bioactive molecules in their native or substantially near-native form and preventing or reduce aggregation. In particular, the present invention relates to precipitation-protective or stabilizing additives and a method of using said precipitation-protective/stabilizing additives to protect and maintain the bioactive molecules in a native or substantially near-native form and to prevent or reduce aggregation during or following precipitation to form particles.

Abstract: The present invention relates to the provision of a novel method for preparing dry amorphous precipitated protein particles. In particular to a method provides amorphous precipitated protein particles suitable for use in dry protein formulations which can be reconstituted to provide clear, foam free concentrated protein solutions.

Abstract: The present invention relates to the provision of a novel method for the reconstitution of dry formulations comprising biomolecules, and in particular, to dry protein formulations, and to pharmaceutical or veterinary products suitable for parenteral administration containing reconstituted formulations prepared according to the novel method of the invention.

Abstract: The present invention relates to the provision of micron or sub-micron sized particles formed from one or more water-soluble crystals comprising a surface coating comprising one or more bioactive molecules wherein the particles are prepared such that in use the release of the bioactive molecule(s) is/are delayed and/or continually released over a period of time. Processes for the preparation of said particles, as well as the particles themselves are described, as well as uses of the particles.

Abstract: The present invention relates to the provision of micron or sub-micron sized particles formed from one or more water-soluble crystals comprising a surface coating comprising one or more bioactive molecules wherein the particles are prepared such that in use the release of the bioactive molecule(s) is/are delayed and/or continually released over a period of time. Processes for the preparation of said particles, as well as the particles themselves are described, as well as uses of the particles.

Abstract: The present invention relates to maintaining bioactive molecules in their native or substantially near-native form and preventing or reduce aggregation. In particular, the present invention relates to precipitation-protective or stabilising additives and a method of using said precipitation-protective/stabilising additives to protect and maintain the bioactive molecules in a native or substantially near-native form and to prevent or reduce aggregation during or following precipitation to form particles.

Abstract: A liquid is filtered with a microsieve. Use is made of a crossflow channel running along a supply surface of the microsieve, and of a drain connected to a drain surface of the microsieve. During a filtering phase, a pressure drop is maintained from a point in the crossflow channel upstream of the microsieve to a point in the drain. The filtering phase is repeatedly interrupted by reducing a flow limitation in the crossflow channel downstream of the microsieve, such that a pressure difference across the microsieve reverses sign. As a result, the pressure reversal coincides with an increase of the flow through the crossflow channel, with a strongly cleaning effect on the microsieve.

Abstract: This invention relates in general to micron or sub-micron particles comprising one or more water-soluble crystals wherein the crystals have a surface coating comprising one or more bioactive molecules as well as efficient methods of forming such particles and rapid methods for screening preferred conditions to form such particles. The particles are suitable for pharmaceutical formulations.

Abstract: A liquid is filtered with a microsieve. Use is made of a crossflow channel running along a supply surface of the microsieve, and of a drain connected to a drain surface of the microsieve. During a filtering phase, a pressure drop is maintained from a point in the crossflow channel upstream of the microsieve to a point in the drain. The filtering phase is repeatedly interrupted by reducing a flow limitation in the crossflow channel downstream of the microsieve, such that a pressure difference across the microsieve reverses sign. As a result, the pressure reversal coincides with an increase of the flow through the crossflow channel, with a strongly cleaning effect on the microsieve.

Abstract: This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.

Abstract: A method and device for placing a component on an elongate, strip-shaped support which is provided with indexing holes and with a repetitive pattern, the positions of the patterns relative to indexing holes situated near an imaging device and positioned by means of pins being determined by means of this imaging device, after which the positions of the patterns relative to a component placement device are calculated, and subsequently a component is placed on a pattern in a desired position.

Abstract: A method, oven, and device for heating a strip-shaped carrier in an oven, which carrier is passed through the oven by a transport device, while the oven is displaced in a direction opposed to the transport direction when a malfunction is detected in the supply or removal of the strip-shaped carrier.

Abstract: An electrical component with an electric circuit element having two mutually parallel external leads which are directed parallel to the end faces of the circuit element which element is secured in a housing which is open on one side by an electrically insulating material, having the particularity that two pairs of resilient clamping members extend from side walls of the housing. The resilient clamping members of each respective pair converge inwardly and clamp a respective external lead of the circuit element in such a position that the leads are centered with respect to the walls of the housing.

Abstract: A drive for a variable-stroke swash plate machine, comprising a rotatably journalled shaft and a swash plate mounted so that the plate cannot rotate with respect to the shaft during operation. The plate is journalled on the shaft so that it is rotatable about an axis of rotation which intersects the shaft axis at an acute angle. A first conical gear on the plate engages a second conical gear on a sleeve arranged coaxially around the shaft. Control means rotate the sleeve and second conical gear with respect to the shaft.

Abstract: A hot-gas reciprocating machine comprises two intercommunicating spaces of variable volume and two pistons (1 and 11) for varying the volumes of these spaces. The two pistons are coupled to two parallel crank shafts (16 and 17) and are movable with an adjustable phase difference. For balancing the engine a system of counterweights is provided comprising a counterweight (30, 31) on each crank shaft and a counterweight (32, 33) on each of two auxiliary shafts (26, 28) which are coupled one to each crank shaft for rotation therewith at the same speed as and in the opposite direction, each auxiliary shaft extending parallel with the associated crank shaft on the side thereof remote from the other crank shaft.

Abstract: A matting comprised of a plurality of continuous amorphous synthetic thermoplastic filaments having an equivalent diameter of about 0.1 to 2.0 millimeters is disclosed to be used for the ground stabilization of road beds. The filaments comprising the matting are arranged in a number of superimposed contacting rows with an overlapping intersection of the loops of adjacent filaments in at least the same row with superficial bonding of the filaments at their points of intersection.