Patents by Inventor Jan W. Groenendaal

Jan W. Groenendaal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5264222
    Abstract: Oral pharmaceutical compositions in unit dosage form, especially capsules, comprising solid Colloidal Bismuth Subcitrate (CBS), optionally one or more auxilliary medicaments and excipients, the dosage units having a packing density of between 0.06 and 0.60 grams of CBS per ml.
    Type: Grant
    Filed: July 6, 1992
    Date of Patent: November 23, 1993
    Assignee: Gist-Brocades N.V.
    Inventors: Jan W. Groenendaal, Aart Muhlenbruch
  • Patent number: 5066436
    Abstract: A process for microencapsulating bioactive substances in biocompatible polymers according to the phase-separation principle, wherein an excess of an ethyl or isopropyl ester of a straight-chain fatty acid having 12-18 carbon atoms is used as the hardening liquid, and the pharmaceutical compositions containing the microcapsules prepared by this process. Isopropyl myristate and isopropyl palmitate are preferred hardening liquids.
    Type: Grant
    Filed: December 27, 1989
    Date of Patent: November 19, 1991
    Assignee: Gist-Brocades N.V.
    Inventors: Joseph Komen, Jan W. Groenendaal
  • Patent number: 4607029
    Abstract: Novel sodium amoxicillin preparations which are easily converted into stable, suitably injectable solutions which are free of allergic reactions-causing chemicals and which contain besides sodium amoxicillin, a small amount of sodium hydroxide and optionally also a small amount of sodium chloride, and a process for their preparation and a process for the preparation of aqueous sodium amoxicillin containing injection solutions. The sodium amoxicillin preparations are prepared by the as fast but gradual addition as possible of an excess of sodium hydroxide to a suspension of amoxicillin trihydrate in water until the amoxicillin has completely dissolved, whereafter optionally a part of the excess of base is immediately neutralized with hydrochloric acid while the temperature is kept between 0.degree.-30.degree. C., followed by sterile filtration of the obtained solution, freezing the solution and freeze drying the obtained solid in flasks or in bulk.
    Type: Grant
    Filed: April 23, 1985
    Date of Patent: August 19, 1986
    Assignee: Gist-Brocades N.V.
    Inventors: Hayo de Jonge, Jan W. Groenendaal, Gerrit J. Sijbrands, Annita Bagerman-Deetman