Patents by Inventor Jan W. Trofast

Jan W. Trofast has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5562923
    Abstract: A process for providing water-soluble micronized pharmaceutically acceptable inhalable substances, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of the pharmaceutically acceptable substances. This process is carried out by the steps of reducing, if necessary, the residual water from the micronized substance by drying at an elevated temperature and/or vacuum; conditioning the dried, micronized pharmaceutically acceptable inhalable substances with a solvent; and eliminating residual solvent by storing under dry conditions as, e.g., in a vacuum or by purging with a dry, inert gas.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 8, 1996
    Assignee: Aktiebolaget Astra
    Inventors: Jan W. Trofast, Eva A. Trofast, Edib Jakupovic, Katarina U. Bystrom
  • Patent number: 5434304
    Abstract: The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to certain formoterol related compounds per se.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: July 18, 1995
    Assignee: Aktiebolaget Astra
    Inventors: Jan W. Trofast, Edib Jakupovic, Katarina L. Mansson
  • Patent number: 5215979
    Abstract: The invention refers to compounds having activity against inflammatory, allergic, and dermatological conditions. The compounds are characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula R.sub.1 is selected from a straight or branched hydrocarbon chain having 1-4 carbon atoms.The invention also refers to processes for the preparation of these compounds, pharmaceutical preparations containing one of the compounds and a method for the treatment of inflammatory, allergic, muscoskeletal and dermatological conditions.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: June 1, 1993
    Assignee: Aktiebolaget Draco
    Inventors: Paul H. Andersson, Per T. Andersson, Bengt I. Axelsson, Ralph L. Brattsand, Bror A. Thalen, Jan W. Trofast
  • Patent number: 4950659
    Abstract: The invention refers to compounds having anti-inflamatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula the 1,2-position is saturated or is a double bondX.sub.1 is selected from hydrogen, fluorine, chlorine and bromineX.sub.2 is selected from hydrogen, fluorine, chlorine and bromineR.sub.1 is selected from hydrogen or a straight or branched hydrocarbon chain having 1-4 carbon atomsR.sub.2 is selected from hydrogen or straight and branched hydrocarbon chains having 1-10 carbon atoms andR.sub.3 is selected from ##STR2## is O or S R.sub.4 is selected from hydrogen, straight or branched hydrocarbon chains having 1-10 carbon atoms or from phenylR.sub.5 is selected from hydrogen or methyl andR.sub.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: August 21, 1990
    Assignee: Aktiebolaget Draco
    Inventors: Paul H. Andersson, Per T. Andersson, Bengt I. Axelsson, Bror A. Thalen, Jan W. Trofast
  • Patent number: 4804656
    Abstract: The invention refers to compounds having anti-inflammatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula X.sub.1 represents a hydrogen, chlorine, bromine or fluorine atom;X.sub.2 represents a hydrogen, chlorine, bromine or fluorine atom;R.sub.1 represents a .beta.-hydroxy group, a .beta.-chlorine atom or an oxo group;R.sub.2 represents a hydrogen atom, a methylene group or an .alpha.- or .beta.-methyl group;R.sub.3 represents a hydrogen atom or an acyl group of 1 through 8 carbon atoms;R.sub.4 represents a hydrogen atom, a (C.sub.1 -C.sub.5) alkyl group or a phenyl group;R.sub.5 represents a hydrogen atom, a (C.sub.1 -C.sub.5) alkyl group or a phenyl group;Y represents either CR.sub.7 R.sub.8, O, S or NR.sub.9, where R.sub.7, R.sub.8 and R.sub.9 are selected from hydrogen or from straight or branched hydrocarbon chains having 1-8 carbon atoms or from a phenyl group.R.sub.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: February 14, 1989
    Assignee: Aktiebolaget Draco
    Inventors: Paul H. Andersson, Per T. Andersson, Bengt I. Axelsson, Bror A. Thalen, Jan W. Trofast
  • Patent number: 4693999
    Abstract: Pharmaceutical composition for administration primarily to the respiratory tract when treating and controlling anti-inflammatory conditions comprising liposomes in combination with a compound of the formula ##STR1## and R.sup.1 is a saturated or unsaturated, straight or branched alkyl group with 11-19 carbon atoms and R is H, --COCH.sub.3, --COC.sub.2 H.sub.5, --CO(CH.sub.2).sub.2 CH.sub.3 or --CO(CH.sub.2).sub.3 CH.sub.3.The invention also refers to the compounds of the formula I per se processes for preparation of these compounds and to a method for the treatment of inflammatory conditions.
    Type: Grant
    Filed: July 3, 1985
    Date of Patent: September 15, 1987
    Assignee: Aktiebolaget Draco
    Inventors: Bengt I. Axelsson, Ralph L. Brattsand, Carl M. O. Dahlback, Leif A. Kallstrom, Jan W. Trofast