Abstract: A medical device includes a handle including an axle, a device shaft extending from the handle to a distal end, and a control device. The control device is coupled to the handle, and the control device includes a knob. The knob is rotatable relative to the handle. The control device also includes a control shaft extending from the knob, at least one spring clutch including two legs, and a spool. The spool is rotatable relative to the axle. The control device also includes one or more wires coupled to the spool. Rotation of the knob is configured to rotate the control shaft, causing the at least one spring clutch to loosen, the spool to rotate, and the one or more wires to move.

Abstract: A motor vehicle shell of a motor vehicle includes a frame structure that is formed by crossmembers and by longitudinal members. The frame structure is closed peripherally and protrudes downwardly in a vertical direction of the motor vehicle from a base element. A receiving chamber for receiving an electrical energy store is delimited by the frame structure. A cover is formed separately from the frame structure and is disposed opposite the base element. The receiving chamber is closed downwardly in the vertical direction of the motor vehicle by the cover. An annular and dimensionally stable intermediary element is formed separately from the frame structure and separately from the cover. The intermediary element is disposed between the frame structure and the cover and the intermediary element is fixed at least in a liquid-tight manner on the frame structure by a firmly bonded connection.

Abstract: A method comprises obtaining a transmission signal to be power-amplified in a power amplifier (361) prior to transmission; separating the transmission signal into two or more polyphase components of the transmission signal; feeding one or more polyphase components of the transmission signal comprised in the two or more polyphase components to each of two or more parallel predistortion circuits (320,321,322); selecting a dedicated predistortion model and dedicated predistortion coefficients for each of the two or more parallel predistortion circuits (320,321,322); performing non-linear memory-based modeling on the transmission signal according to the selected dedicated predistortion models and coefficients using the one or more polyphase components; and combining output signals of the two or more parallel predistortion circuits (320,321,322) to form a predistorted transmission signal (y[n]) to be applied to the power amplifier (361).

Abstract: A method for operating a vehicle operating system, wherein a navigation system provides map information, and a monitoring system monitors driver assistance information, which are displayed on a display device, wherein the navigation system, the monitoring system, the display device, and an operating device are coupled to a control device for data transfer, to display the map information and/or driver assistance information on the display, wherein an operating action is carried out by the operating device in order to change a display scale and/or a display angle in relation to a road surface between a first perspective and a second perspective, wherein the display scale and/or angle are adjusted continuously and/or discretely in at least two steps located within the two perspectives on a virtual visualization path, and wherein the first perspective is substantially perpendicular to the road surface and the second perspective is substantially parallel to the road surface.

Abstract: A method for predicting a response to and/or benefit of chemotherapy, including neoadjuvant chemotherapy, in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer, said method comprising the steps of: (a) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP, indicative of a response to chemotherapy for a tumor, or (b) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, BIRC5, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP; indicative of a response to chemotherapy for a tumor (c) mathematically combining expression level values for the genes of the said set which values were determined in the tumor sample to yield a combined score, wherein said combined score is predicting said response and/or benefit of chemotherapy.

Abstract: Methods and systems are provided for a turbocharger system. In one example, a system comprises an actuator configured to adjust a position of a plurality of guide vanes and a position of a coolant valve configured to adjust coolant flow through a turbine coolant jacket or a compressor coolant jacket.

Abstract: The present invention relates to the use as fungicides of compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to the compounds I and composition for compounds of formula I.

Abstract: A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also provided. A texturized coating (18), a cap layer (20) and/or other methods may be used to increase particle loading capacity of the balloon.

Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.

Abstract: Vascular valve systems for treating calcified vascular vessel valves by delivery of one or more calcium chelating agents are described. The vascular valve systems can include an expandable stent, a valve, and a material layer. The material layer includes a hydrogel, calcium chelating agent, and an acidifying agent. Methods of making the vascular valve systems are also described.

Abstract: A medical device such as a catheter includes a shaft that extends from a proximal region to a distal region and that defines a shaft lumen extending therethrough. A hub is secured relative to the proximal region. A strain relief extends proximally over the shaft from the hub. At least one of the hub and the strain relief include a printed battery.

Abstract: Medical devices for renal nerve ablation are disclosed. An example medical device for renal nerve ablation may include a catheter shaft having a distal region. The device may include an expandable member coupled to the distal region, a flexible circuit assembly coupled to the expandable member, and a pressure sensor disposed along the expandable member and positioned adjacent to the flexible circuit assembly. The flexible circuit assembly may include one or more pairs of bipolar electrodes and a temperature sensor.

Abstract: The present disclosure, in its various aspects, is directed to expandable guide devices, implementation methods, and related systems. In one example, an expandable guide device is configured to receive an instrument through an instrument lumen of the device. Each of a plurality of expandable members are disposed circumferentially about a body of the device that defines the instrument lumen, and each expandable member is configured to be independently transitionable between an expanded configuration and an unexpanded configuration.

Abstract: A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also provided. A texturized coating (18), a cap layer (20) and/or other methods may be used to increase particle loading capacity of the balloon.

Abstract: Medical devices for renal nerve ablation are disclosed. An example medical device for renal nerve ablation may include a catheter shaft having a distal region. The device may include an expandable member coupled to the distal region, a flexible circuit assembly coupled to the expandable member, and a pressure sensor disposed along the expandable member and positioned adjacent to the flexible circuit assembly. The flexible circuit assembly may include one or more pairs of bipolar electrodes and a temperature sensor.

Abstract: A mitral valve leaflet repair system may include a delivery catheter having at least one lumen extending proximally from a distal end of the delivery catheter, a plurality of anchor elements disposed within the at least one lumen, each of the plurality of anchor elements being configured to extend through one layer of mitral valve leaflet tissue, and a securing element configured to secure at least two of the plurality of anchor elements together on one side of the mitral valve leaflet tissue. The at least one lumen may include a suction lumen configured to grasp a mitral valve leaflet prior to extending the plurality of anchor elements through one layer of mitral valve leaflet tissue.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid from the fluid reservoir to the inflatable member during an inflation cycle. The pump assembly includes a first pump configured to inject the fluid into the inflatable member according to a first flow rate, and a second pump configured to inject fluid into the inflatable member according to a second flow rate, where the second flow rate is less than the first flow rate.

Abstract: A medical device for sympathetic nerve ablation may include a catheter shaft, an expandable member disposed on or coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit having a plurality of layers. The expandable member may be configured to shift between an unexpanded configuration and an expanded configuration. The plurality of electrode assemblies may be disposed on an outer surface of the expandable member. Each of the plurality of electrode assemblies may include enhanced tear resistance properties such as through the inclusion of a reinforcement structure with one or more of the layers of the electrode assemblies.

Abstract: An accessory device for use with a medical device includes a first cuff secured to a distal end of the medical device, a second cuff secured to the medical device proximal of the first cuff, an actuator, and at least one actuation wire extending from the first cuff, through the second cuff, to the actuator.

Abstract: Device sand methods for improving cardiac function are provided. The device includes a dome structure having a top end with an engagement element disposed thereon. The dome structure is moveable from a first inside out configuration to a second deployed configuration, and the dome structure is biased in the second deployed configuration. The dome structure includes a plurality of anchor members disposed around a bottom open end of the dome structure.