Abstract: A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also provided. A texturized coating (18), a cap layer (20) and/or other methods may be used to increase particle loading capacity of the balloon.

Abstract: A device for treating hemorrhoids includes a first ligating member which moves between a first position in which the first member is tightened to a degree required to maintain a desired position of the first member around the first portion without significantly cutting off blood flow and a second configuration in which the first member is cinched down around the first portion to substantially cut off blood flow to the encircled first portion. Also, the device includes a first applicator having a proximal lumen and first and second opposed distal lumens open to the proximal lumen. The first member is extending from a proximal end distally through the proximal lumen into the first lumen to exit a distal end of the first lumen, loop around and enter the distal end of the second lumen. The first member is passing through the second lumen into the proximal lumen.

Abstract: A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also provided. A texturized coating (18), a cap layer (20) and/or other methods may be used to increase particle loading capacity of the balloon.

Abstract: An inlet tube of a circulatory support device includes a first end configured to receive incoming blood and a second end coupled to a first end of a blood pump. A lumen extends from the first end to the second end, and a spiral feature is disposed within the lumen and configured to support a spiral flow of the incoming blood.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has magnesium and one or more additional alloying elements, including aluminum. The alloy has a microstructure comprising equiaxed Mg-rich solid solution phase grains having an average grain diameter of less than or equal to 5 microns and continuous or discontinuous second-phase precipitates in grain boundaries between the Mg-rich solid solution-phase grains, the second-phase precipitates having an average longest dimension of 0.5 micron or less.

Abstract: An accessory device for use with a medical device includes a first cuff secured to a distal end of the medical device, a second cuff secured to the medical device proximal of the first cuff, an actuator, and at least one actuation wire extending from the first cuff, through the second cuff, to the actuator.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid from the fluid reservoir to the inflatable member during an inflation cycle. The pump assembly includes a first pump configured to inject the fluid into the inflatable member according to a first flow rate, and a second pump configured to inject fluid into the inflatable member according to a second flow rate, where the second flow rate is less than the first flow rate.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid from the fluid reservoir to the inflatable member during an inflation cycle. The pump assembly includes a first pump configured to inject the fluid into the inflatable member according to a first flow rate, and a second pump configured to inject fluid into the inflatable member according to a second flow rate, where the second flow rate is less than the first flow rate.

Abstract: A medical device includes a handle including an axle, a device shaft extending from the handle to a distal end, and a control device. The control device is coupled to the handle, and the control device includes a knob. The knob is rotatable relative to the handle. The control device also includes a control shaft extending from the knob, at least one spring clutch including two legs, and a spool. The spool is rotatable relative to the axle. The control device also includes one or more wires coupled to the spool. Rotation of the knob is configured to rotate the control shaft, causing the at least one spring clutch to loosen, the spool to rotate, and the one or more wires to move.

Abstract: A medical device includes a handle including an axle, a device shaft extending from the handle to a distal end, and a control device. The control device is coupled to the handle, and the control device includes a knob. The knob is rotatable relative to the handle. The control device also includes a control shaft extending from the knob, at least one spring clutch including two legs, and a spool. The spool is rotatable relative to the axle. The control device also includes one or more wires coupled to the spool. Rotation of the knob is configured to rotate the control shaft, causing the at least one spring clutch to loosen, the spool to rotate, and the one or more wires to move.

Abstract: A system, device, and methods for providing protection of an appendage of a human or animal is provided. The protective system can be a protective boot that includes a cage sized and configured to follow the contours of the distal limb of an animal such as a horse. A plurality of openings are defined in the cage. The cage provides protection of the distal limb and permeability of air flow towards and/or around the distal limb.

Abstract: A device for treating hemorrhoids includes a first ligating member which moves between a first position in which the first member is tightened to a degree required to maintain a desired position of the first member around the first portion without significantly cutting off blood flow and a second configuration in which the first member is cinched down around the first portion to substantially cut off blood flow to the encircled first portion. Also, the device includes a first applicator having a proximal lumen and first and second opposed distal lumens open to the proximal lumen. The first member is extending from a proximal end distally through the proximal lumen into the first lumen to exit a distal end of the first lumen, loop around and enter the distal end of the second lumen. The first member is passing through the second lumen into the proximal lumen.

Abstract: A device for treating hemorrhoids includes a first ligating member which moves between a first position in which the first member is tightened to a degree required to maintain a desired position of the first member around the first portion without significantly cutting off blood flow and a second configuration in which the first member is cinched down around the first portion to substantially cut off blood flow to the encircled first portion. Also, the device includes a first applicator having a proximal lumen and first and second opposed distal lumens open to the proximal lumen. The first member is extending from a proximal end distally through the proximal lumen into the first lumen to exit a distal end of the first lumen, loop around and enter the distal end of the second lumen. The first member is passing through the second lumen into the proximal lumen.

Abstract: Embodiments herein relate to systems and methods for thawing cells using magnetic particles, such as Curie-magnetic or Néel-magnetic particles. In an embodiment, a cell storage medium for cryopreservation is included. The cell storage medium can include a cryoprotective agent; and a plurality of particles comprising a magnetic material. In an embodiment, a method for thawing a frozen cell sample is included. The method can include obtaining a frozen cell sample comprising particles, the particles comprising a magnetic material and applying an alternating electromagnetic field to the frozen cell sample to induce heating of the magnetic material. Other embodiments are also included herein.

Abstract: Grooming tools and systems for grooming an animal. An illustrative grooming tool may comprise a housing having a top edge, a bottom edge, and a sidewall extending between the top edge and the bottom edge. A first pad and a second pad may each form a portion of a bottom surface of the housing. A plurality of cleaning fibers may extend from each of the first and second pads. A motor configured to drive rotation of the pads may be disposed within the cavity of the housing. The first pad may be configured to rotate in a first direction relative to a center of the bottom surface of the housing and the second pad may be configured to rotate in a second direction opposite the first direction.

Abstract: An accessory device for use with a medical device includes a first cuff secured to a distal end of the medical device, a second cuff secured to the medical device proximal of the first cuff, an actuator, and at least one actuation wire extending from the first cuff, through the second cuff, to the actuator.

Abstract: An accessory device for use with a medical device includes a first cuff secured to a distal end of the medical device, a second cuff secured to the medical device proximal of the first cuff, an actuator, and at least one actuation wire extending from the first cuff, through the second cuff, to the actuator.

Abstract: A device includes a balloon configured for inflation with a light-diffusing fluid and configured, upon inflation, to expand a body lumen within which it is positioned and a flexible light-emitting device attached to the balloon having a light-emitting side facing radially inward toward the fluid so that, during a medical procedure, light emitted from the light-emitting side is diffused by the fluid and illuminates a treatment area within the body lumen proximal to the balloon.

Abstract: A mitral valve leaflet repair system may include a delivery catheter having at least one lumen extending proximally from a distal end of the delivery catheter, a plurality of anchor elements disposed within the at least one lumen, each of the plurality of anchor elements being configured to extend through one layer of mitral valve leaflet tissue, and a securing element configured to secure at least two of the plurality of anchor elements together on one side of the mitral valve leaflet tissue. The at least one lumen may include a suction lumen configured to grasp a mitral valve leaflet prior to extending the plurality of anchor elements through one layer of mitral valve leaflet tissue.

Abstract: A cooling article includes thermally conductive material and heat absorbing material comprising a phase change material having a phase change temperature greater than 0° C. The cooling article may be used to cool a subject or the limb of a subject. A cooling article may include passive cooling material and reinforcing fibers configured to support the passive cooling layer, where the cooling article is configured to conform to a portion of a subject's body. The cooling article may be a sheet, a blanket, or a sleeve. A method of cooling a subject includes cooling the cooling article to a temperature below the phase change temperature; and applying the cooling article to the subject.