Patents by Inventor Jan Werij

Jan Werij has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fungal production of FDCA
    Patent number: 11034979
    Abstract: The invention relates to fungal cells for the production of FDCA. The fungal cell is genetically modified to have at least one of a) a genetic modification that confers to or increases in the cell the ability to oxidize 5-hydroxymethyl-2-furancarboxylic acid to 5-formyl-2-furoic acid; and, b) a genetic modification that reduces catabolism of 2,5-furandicarboxylic acid in the cell. The fungal cell can further be genetically modified to increase the cell's ability to oxidize furanic aldehydes to the corresponding furanic carboxylic acids. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) wherein the cells of the invention are used for oxidation of a furanic precursors of FDCA.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: June 15, 2021
    Assignee: Purac Biochem B.V.
    Inventors: Johannes Adrianus Maria de Bont, Harald Johan Ruijssenaars, Jan Werij
  • FDCA-decarboxylating monooxygenase-deficient host cells for producing FDCA
    Publication number: 20200102584
    Abstract: The invention relates to fungal cells for the production of FDCA. The fungal cell has genetic modification that reduces specific 2,5-furandicarboxylic acid (FDCA) decarboxylating monooxygenase activity in the cell, as compared to a corresponding parent cell lacking the genetic modification. The fungal cell can further be genetically modified to increase the cell's ability to oxidize furanic aldehydes to the corresponding furanic carboxylic acids. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) wherein the cells of the invention are used for oxidation of a furanic precursors of FDCA to FDCA.
    Type: Application
    Filed: March 21, 2018
    Publication date: April 2, 2020
    Applicant: Purac Biochem B.V.
    Inventors: Johannes Adrianus Maria de Bont, Harald Johan Ruijssenaars, Jan Werij
  • Fungal production of FDCA
    Publication number: 20180265896
    Abstract: The invention relates to fungal cells for the production of FDCA. The fungal cell is genetically modified to have at least one of a) a genetic modification that confers to or increases in the cell the ability to oxidize 5-hydroxymethyl-2-furancarboxylic acid to 5-formyl-2-furoic acid; and, b) a genetic modification that reduces catabolism of 2,5-furandicarboxylic acid in the cell. The fungal cell can further be genetically modified to increase the cell's ability to oxidize furanic aldehydes to the corresponding furanic carboxylic acids. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) wherein the cells of the invention are used for oxidation of a furanic precursors of FDCA.
    Type: Application
    Filed: September 21, 2016
    Publication date: September 20, 2018
    Applicant: Purac Biochem B.V.
    Inventors: Johannes Adrianus Maria de Bont, Harald Johan Ruijssenaars, Jan Werij