Abstract: The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.

Abstract: The invention relates to antimicrobial peptides, pharmaceutical compositions comprising the peptides and to uses thereof for in the treatment or prevention of microbial, bacterial, fungal, viral and parasitic infection.

Abstract: The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.

Abstract: Methods and systems for automatically generating robust metrology targets which can accommodate a variety of lithography processes and process perturbations. Individual steps of an overall lithography process are modeled into a single process sequence to simulate the physical substrate processing. That process sequence drives the creation of a three-dimensional device geometry as a whole, rather than “building” the device geometry element-by-element.

Abstract: The disclosure relates to antimicrobial peptides, pharmaceutical compositions comprising the peptides and to uses thereof for treatment or prevention of microbial, bacterial, fungal, viral and parasitic infection.

Abstract: Aspects of the present invention are generally directed to a modulation enhancement strategy that helps improve ITD perception by explicitly modulating the electrical stimulation signal. In an embodiment, the timing of the applied modulations is based on amplitude inflections (i.e., peaks or troughs) in the received sound signal. In an embodiment, the identified inflections (i.e., peaks or troughs) represent the most energetic portions of the signal over a particular time period (e.g., the time period prior to the inflection having a length equal to the expected fundamental period of the signal. Further, in an embodiment, the cochlear implant applies a delay to the stimulation signal to help maintain interaural timing cues. The application of this delay helps account for the traveling wave delay in the acoustic path of the opposite ear in embodiments in which the opposite ear is fitted with a hearing aid or is not fitted with a hearing device.

Abstract: The invention relates to an exercise device, such as a bicycle or spinning bike, comprising a frame and a set of crank arms connected to a rotary shaft having an imaginary rotational axis stationary with respect to the frame. A further set of crank arms is mounted eccentrically with respect to the rotational axis of the shaft.

Abstract: The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.

Abstract: Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.

Abstract: A Coriolis flow sensor including a loop-shaped Coriolis tube mounted in a housing with two ends lying next to one another, the ends being fixed in a fixation element, while the portion of the tube located between the ends lies free from the housing, which flow sensor includes an excitation element for causing the tube to oscillate about an excitation axis as well as a detection element for detecting displacements of portions of the tube during operation. The tube is connected through the fixation element to a balancing member, the assembly of the balancing member and the tube being resiliently arranged with respect to the housing, while the excitation element are arranged to rotate the tube and the balancing member with counter-phase about the excitation axis.

Abstract: Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.

Abstract: A Coriolis flow sensor including a loop-shaped Coriolis tube mounted in a housing with two ends lying next to one another, the ends being fixed in a fixation element, while the portion of the tube located between the ends lies free from the housing, which flow sensor includes an excitation element for causing the tube to oscillate about an excitation axis as well as a detection element for detecting displacements of portions of the tube during operation.

Abstract: A Coriolis flow sensor including a loop-shaped Coriolis tube mounted in a housing with two ends lying next to one another, the ends being fixed in a fixation element, while the portion of the tube located between the ends lies free from the housing, which flow sensor includes an excitation element for causing the tube to oscillate about an excitation axis as well as a detection element for detecting displacements of portions of the tube during operation. The tube is connected through the fixation element to a balancing member, the assembly of the balancing member and the tube being resiliently arranged with respect to the housing, while the excitation element are arranged to rotate the tube and the balancing member with counter-phase about the excitation axis.

Abstract: Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.

Abstract: Disclosed is a method and system for allowing a recipient of a hearing aid device, and in one aspect, a bilateral hearing aid system, to locate the source of a sound signal about the recipient. The method uses localization cues in the sound signal and modifies these to provide useable localization cues to generate a stimulating signal for application to the recipient. In one example, a detected localization cue such as an interaural level difference (ILD) is transposed to a lower frequency.

Abstract: The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.

Abstract: A liposomal composition, preferably a vaccine, comprising liposomes formed of liposome forming compounds, containing coentrapped polysaccharide antigen and T-cell dependent protein carrier, such as tetanus toxoid or diphtheria toxin modified to render it non-toxic. The invention is of use in the production of vaccines against Haemophilus influenzae, Streptococcus pneumoniae or Neisseria meningitidis.

Abstract: The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.

Abstract: The present invention relates to conjugates comprising a peptide of at least 10 amino acid residues comprising the amino acid sequence GITELKKL for induction of potent humoral and cellular immune responses when administered to subjects having antibodies against tetanus toxoid. In one embodiment the invention relates to a prophylactic and therapeutic vaccine and in a further embodiment the invention relates to the treatment or prevention of cancer or an infectious disease.

Abstract: Aspects of the present invention are generally directed to a modulation enhancement strategy that helps improve ITD perception by explicitly modulating the electrical stimulation signal. In an embodiment, the timing of the applied modulations is based on amplitude inflections (i.e., peaks or troughs) in the received sound signal. In an embodiment, the identified inflections (i.e., peaks or troughs) represent the most energetic portions of the signal over a particular time period (e.g., the time period prior to the inflection having a length equal to the expected fundamental period of the signal. Further, in an embodiment, the cochlear implant applies a delay to the stimulation signal to help maintain interaural timing cues. The application of this delay helps account for the traveling wave delay in the acoustic path of the opposite ear in embodiments in which the opposite ear is fitted with a hearing aid or is not fitted with a hearing device.