Patents by Inventor Jan Zygmunt
Jan Zygmunt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150133536Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: ApplicationFiled: January 23, 2015Publication date: May 14, 2015Applicant: Tapestry Pharmaceuticals, Inc.Inventors: Jan ZYGMUNT, James FERRARA, James D. MCCHESNEY
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Patent number: 8962870Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: GrantFiled: November 24, 2010Date of Patent: February 24, 2015Assignee: Tapestry Pharmaceuticals, Inc.Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
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Publication number: 20150025266Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: July 16, 2013Publication date: January 22, 2015Applicant: Pioneer Energy, Inc.Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
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Patent number: 8927789Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: GrantFiled: July 16, 2013Date of Patent: January 6, 2015Assignee: Pioneer EnergyInventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
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Publication number: 20140283438Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: March 20, 2013Publication date: September 25, 2014Applicant: Pioneer EnergyInventors: John T. Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
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Publication number: 20140256992Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: March 8, 2013Publication date: September 11, 2014Applicant: PIONEER ENERGYInventors: John Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
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Publication number: 20140245658Abstract: Ketene chemistry and hydrogenation reactions are used to synthesize fuels and chemicals. Ketene from acetic acid is hydrogenated to form fuels and chemicals; acetic acid can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc. In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass.Type: ApplicationFiled: February 7, 2014Publication date: September 4, 2014Applicant: PIONEER ENERGY INCInventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
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Publication number: 20130291430Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: March 28, 2013Publication date: November 7, 2013Applicant: Pioneer EnergyInventors: John T. Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
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Publication number: 20130118063Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: November 8, 2012Publication date: May 16, 2013Applicant: Pioneer EnergyInventors: John Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
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Patent number: 8423526Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.Type: GrantFiled: January 30, 2012Date of Patent: April 16, 2013Assignee: ThinkVillage-OIP, LLCInventor: Jan Zygmunt
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Publication number: 20120130707Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.Type: ApplicationFiled: January 30, 2012Publication date: May 24, 2012Inventor: Jan Zygmunt
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Publication number: 20120077871Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: ApplicationFiled: November 24, 2010Publication date: March 29, 2012Applicant: TAPESTRY PHARMACEUTICALS, INC.Inventors: Jan ZYGMUNT, James FERRARA, James D. MCCHESNEY
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Patent number: 8131714Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.Type: GrantFiled: December 31, 2008Date of Patent: March 6, 2012Assignee: Think Village-OIP, LLCInventor: Jan Zygmunt
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Patent number: 7879904Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.Type: GrantFiled: June 2, 2010Date of Patent: February 1, 2011Assignee: Tapestry Pharmaceuticals, Inc.Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
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Publication number: 20100324128Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.Type: ApplicationFiled: June 2, 2010Publication date: December 23, 2010Applicant: TAPESTRY PHARMACEUTICALS, INC.Inventors: Jan ZYGMUNT, James FERRARA, James D. MCCHESNEY
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Patent number: 7745650Abstract: The present invention relates to taxane analogs for the treatment of cancer having the general formula: wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R3 is hydroxyl or OP1; R4 and R5 are each hydroxyl or R7COO; R6 is hydroxyl, OP2, R7COO, or an ether functionality; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 and P2 are each hydroxyl protecting groups; R8 and R9 are each selected from H, alkyl group, olefinic or aromatic group. The present invention is also directed to production methods and intermediates useful in the formation of these new taxane analogs. The methods may begin with a starting compound, such as paclitaxel or docetaxel, which is converted into a taxane analog through various intermediate compounds.Type: GrantFiled: September 27, 2004Date of Patent: June 29, 2010Assignee: Tapestry Pharmaceuticals, IncInventors: Jan Zygmunt, James Ferrara, James D. McChesney
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Publication number: 20090171949Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.Type: ApplicationFiled: December 31, 2008Publication date: July 2, 2009Inventor: Jan Zygmunt
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Publication number: 20050148657Abstract: The present invention relates to taxane analogs for the treatment of cancer having the general formula: wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R3 is hydroxyl or OP,; R4 and R5 are each hydroxyl or R7COO; R6 is hydroxyl, OP2, R7COO, or an ether functionality; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 and P2 are each hydroxyl protecting groups; R8 and R9 are each selected from H, alkyl group, olefinic or aromatic group. The present invention is also directed to production methods and intermediates useful in the formation of these new taxane analogs. The methods may begin with a starting compound, such as paclitaxel or docetaxel, which is converted into a taxane analog through various intermediate compounds.Type: ApplicationFiled: September 27, 2004Publication date: July 7, 2005Inventors: Jan Zygmunt, James Ferrara, James McChesney
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Publication number: 20050090431Abstract: The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.Type: ApplicationFiled: November 17, 2004Publication date: April 28, 2005Applicant: University of KansasInventors: Valentino Stella, Jan Zygmunt, Ingrid Georg, Muhammad Safadi
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Patent number: 6479679Abstract: The present invention relates to a method of producing paclitaxel from a protected coupled ester compound having a formula: wherein P1 is a hydrogenatable protecting group, comprising the steps of deprotecting the 7-O-position, 3′-N-position and 2′-O-position thereof in the presence of an acid to form a first intermediate compound having a formula: wherein HA is said acid, and benzoylating the first intermediate compound at the 3′-N-position thereby to produce paclitaxel.Type: GrantFiled: April 25, 2001Date of Patent: November 12, 2002Assignee: NaPro BioTherapeutics, Inc.Inventors: Jan Zygmunt, James D. McChesney