Patents by Inventor Jan Zygmunt

Jan Zygmunt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150133536
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Applicant: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan ZYGMUNT, James FERRARA, James D. MCCHESNEY
  • Patent number: 8962870
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: February 24, 2015
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Publication number: 20150025266
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: July 16, 2013
    Publication date: January 22, 2015
    Applicant: Pioneer Energy, Inc.
    Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Patent number: 8927789
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: January 6, 2015
    Assignee: Pioneer Energy
    Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Publication number: 20140283438
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: March 20, 2013
    Publication date: September 25, 2014
    Applicant: Pioneer Energy
    Inventors: John T. Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
  • Publication number: 20140256992
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 11, 2014
    Applicant: PIONEER ENERGY
    Inventors: John Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
  • Publication number: 20140245658
    Abstract: Ketene chemistry and hydrogenation reactions are used to synthesize fuels and chemicals. Ketene from acetic acid is hydrogenated to form fuels and chemicals; acetic acid can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc. In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass.
    Type: Application
    Filed: February 7, 2014
    Publication date: September 4, 2014
    Applicant: PIONEER ENERGY INC
    Inventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Publication number: 20130291430
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: March 28, 2013
    Publication date: November 7, 2013
    Applicant: Pioneer Energy
    Inventors: John T. Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
  • Publication number: 20130118063
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: November 8, 2012
    Publication date: May 16, 2013
    Applicant: Pioneer Energy
    Inventors: John Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
  • Patent number: 8423526
    Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: April 16, 2013
    Assignee: ThinkVillage-OIP, LLC
    Inventor: Jan Zygmunt
  • Publication number: 20120130707
    Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.
    Type: Application
    Filed: January 30, 2012
    Publication date: May 24, 2012
    Inventor: Jan Zygmunt
  • Publication number: 20120077871
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Application
    Filed: November 24, 2010
    Publication date: March 29, 2012
    Applicant: TAPESTRY PHARMACEUTICALS, INC.
    Inventors: Jan ZYGMUNT, James FERRARA, James D. MCCHESNEY
  • Patent number: 8131714
    Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: March 6, 2012
    Assignee: Think Village-OIP, LLC
    Inventor: Jan Zygmunt
  • Patent number: 7879904
    Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: February 1, 2011
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Publication number: 20100324128
    Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 23, 2010
    Applicant: TAPESTRY PHARMACEUTICALS, INC.
    Inventors: Jan ZYGMUNT, James FERRARA, James D. MCCHESNEY
  • Patent number: 7745650
    Abstract: The present invention relates to taxane analogs for the treatment of cancer having the general formula: wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R3 is hydroxyl or OP1; R4 and R5 are each hydroxyl or R7COO; R6 is hydroxyl, OP2, R7COO, or an ether functionality; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 and P2 are each hydroxyl protecting groups; R8 and R9 are each selected from H, alkyl group, olefinic or aromatic group. The present invention is also directed to production methods and intermediates useful in the formation of these new taxane analogs. The methods may begin with a starting compound, such as paclitaxel or docetaxel, which is converted into a taxane analog through various intermediate compounds.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: June 29, 2010
    Assignee: Tapestry Pharmaceuticals, Inc
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Publication number: 20090171949
    Abstract: System and Methods determine a linguistic preference between two or more phrases. Each of the phrases is submitted to at least one search engine as a search string. Search results are retrieved from each of the at least one search engine for each submitted search string and total hit values of each search result are compared. One of the two or more phrases associated with the greatest total hit value are displayed to a user as the preferred phrase.
    Type: Application
    Filed: December 31, 2008
    Publication date: July 2, 2009
    Inventor: Jan Zygmunt
  • Publication number: 20050148657
    Abstract: The present invention relates to taxane analogs for the treatment of cancer having the general formula: wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R3 is hydroxyl or OP,; R4 and R5 are each hydroxyl or R7COO; R6 is hydroxyl, OP2, R7COO, or an ether functionality; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 and P2 are each hydroxyl protecting groups; R8 and R9 are each selected from H, alkyl group, olefinic or aromatic group. The present invention is also directed to production methods and intermediates useful in the formation of these new taxane analogs. The methods may begin with a starting compound, such as paclitaxel or docetaxel, which is converted into a taxane analog through various intermediate compounds.
    Type: Application
    Filed: September 27, 2004
    Publication date: July 7, 2005
    Inventors: Jan Zygmunt, James Ferrara, James McChesney
  • Publication number: 20050090431
    Abstract: The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.
    Type: Application
    Filed: November 17, 2004
    Publication date: April 28, 2005
    Applicant: University of Kansas
    Inventors: Valentino Stella, Jan Zygmunt, Ingrid Georg, Muhammad Safadi
  • Patent number: 6479679
    Abstract: The present invention relates to a method of producing paclitaxel from a protected coupled ester compound having a formula: wherein P1 is a hydrogenatable protecting group, comprising the steps of deprotecting the 7-O-position, 3′-N-position and 2′-O-position thereof in the presence of an acid to form a first intermediate compound having a formula: wherein HA is said acid, and benzoylating the first intermediate compound at the 3′-N-position thereby to produce paclitaxel.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: November 12, 2002
    Assignee: NaPro BioTherapeutics, Inc.
    Inventors: Jan Zygmunt, James D. McChesney