Patents by Inventor Jane A. Gross

Jane A. Gross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MURINE ZCYTOR17 LIGAND POLYPEPTIDES AND POLYNUCLEOTIDES
    Publication number: 20090192292
    Abstract: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: January 29, 2009
    Publication date: July 30, 2009
    Inventors: Cindy A. Sprecher, Joseph L. Kuijper, Maria M. Dasovich, Francis J. Grant, Jane A. Gross, Angela K. Hammond, Rolf E. Kuestner
  • DOSING METHODS FOR TREATING AUTOIMMUNE DISEASES USING A TACI-Ig FUSION PROTEIN SUCH AS ATACICEPT
    Publication number: 20090186040
    Abstract: In various embodiments, the present invention provides methods, compositions, dosing, and administration schedules for treatment of autoimmune diseases, including systemic erythematosus (SLE), for example, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule such as atacicept. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BLyS and APRIL, in particular the use of multiple administrations of the fusion molecule at relatively low dose over the course of the treatment.
    Type: Application
    Filed: June 13, 2008
    Publication date: July 23, 2009
    Inventors: Sharon J. Busby, Jane A. Gross, Jennifer Visich, Ivan Nestorov, Alain Munafo, Orestis Papasouliotis, Claudia Pena Rossi
  • ANTIBODIES TO HUMAN ZCYTOR17 LIGAND
    Publication number: 20090149635
    Abstract: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: August 18, 2008
    Publication date: June 11, 2009
    Inventors: CINDY A. SPRECHER, JOSEPH L. KUIJPER, MARIA M. DASOVICH, FRANCIS J. GRANT, ANGELA K. HAMMOND, JANE A. GROSS
  • Antibodies to murine zcytor17 ligand
    Patent number: 7531636
    Abstract: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: May 12, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Joseph L. Kuijper, Maria M. Dasovich, Francis J. Grant, Angela K. Hammond, Jane A. Gross, Rolf E. Kuestner
  • METHODS OF PREDICTING THERAPEUTIC RESPONSE IN ATOPIC DERMATITIS TO IL-31 ANTAGONISTS
    Publication number: 20090092999
    Abstract: The present invention relates to predicting therapeutic response of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cells in atopic dermatitis. The invention also includes methods of predicting a therapeutically responsive patient population.
    Type: Application
    Filed: September 26, 2008
    Publication date: April 9, 2009
    Inventors: Janine Bilsborough, Jane A. Gross
  • Murine ZCYTOR17 ligand polypeptides
    Patent number: 7507795
    Abstract: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: March 24, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Joseph L. Kuijper, Maria M. Dasovich, Francis J. Grant, Jane A. Gross, Angela K. Hammond, Rolf E. Kuestner
  • TACI-immunoglobulin fusion proteins
    Patent number: 7501497
    Abstract: Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: March 10, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Mark W. Rixon, Jane A. Gross
  • Polynucleotide encoding cytokine receptor zcytor17 multimer
    Patent number: 7494804
    Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: February 24, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Zeren Gao, Joseph L. Kuijper, Maria M. Dasovich, Francis J. Grant, Scott R. Presnell, Theodore E. Whitmore, Angela K. Hammond, Julia E. Novak, Jane A. Gross, Stacey R. Dillon
  • Cytokine zalpha11 ligand fusion proteins
    Patent number: 7491800
    Abstract: The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: February 17, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Julia E. Novak, Scott R. Presnell, Cindy A. Sprecher, Donald C. Foster, Richard D. Holly, Jane A. Gross, Janet V. Johnston, Andrew J. Nelson, Stacey R. Dillon, Angela K. Hammond
  • Cytokine zalpha11 ligand
    Patent number: 7473765
    Abstract: The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: January 6, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Julia E. Novak, Scott R. Presnell, Cindy A. Sprecher, Donald C. Foster, Richard D. Holly, Jane A. Gross, Janet V. Johnston, Andrew J. Nelson, Stacey R. Dillon, Angela K. Hammond
  • Cytokine zcytor17 ligand polynucleotides
    Patent number: 7459293
    Abstract: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: December 2, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Joseph L. Kuijper, Maria M. Dasovich, Francis J. Grant, Angela K. Hammond, Jane A. Gross
  • METHODS OF USING IL-31 TO TREAT AIRWAY HYPER-RESPONSIVENESS AND ASTHMA
    Publication number: 20080260686
    Abstract: Use of IL-31 agonists, including IL-31, are used to treat agonists are used to treat asthma, airway hyper-responsiveness or allergic rhinitis. The method comprise inhibiting, reducing, limiting or minimizing production of proimflammatory cytokines and include administration of the IL-31 agonsit during sensitization or challenge resulting in the asthma, airway hyper-responsiveness or allergic rhinitis state.
    Type: Application
    Filed: January 10, 2008
    Publication date: October 23, 2008
    Inventors: Janine M. Bilsborough, Eric M. Chadwick, Sherri L. Mudri, Yue Yao, Hongping Ren, Jane A. Gross
  • Cytokine zcytor17 ligand polypeptides
    Patent number: 7425325
    Abstract: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: September 16, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Joseph L. Kuijper, Maria M. Dasovich, Francis J. Grant, Angela K. Hammond, Jane A. Gross
  • METHODS FOR TREATING AUTOIMMUNE DISEASES USING A TACI-IG FUSION MOLECULE
    Publication number: 20070274984
    Abstract: In various embodiments, the present invention provides methods and compositions for treatment of autoimmune diseases, including rheumatoid arthritis, for example comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BlyS and APRIL.
    Type: Application
    Filed: May 15, 2007
    Publication date: November 29, 2007
    Applicants: ARES TRADING S.A., ZYMOGENETICS, INC.
    Inventors: Herve Broly, Jennifer Visich, Ivan Nestorov, Sharon Busby, Jane Gross
  • HUMAN TUMOR NECROSIS FACTOR RECEPTOR
    Publication number: 20070264689
    Abstract: Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.
    Type: Application
    Filed: June 22, 2007
    Publication date: November 15, 2007
    Inventors: Jane Gross, Wenfeng Xu, Randal Henne, Francis Grant
  • CYTOKINE ZCYTOR17 LIGAND POLYPEPTIDES AND POLYNUCLEOTIDES
    Publication number: 20070249020
    Abstract: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: December 12, 2006
    Publication date: October 25, 2007
    Inventors: Cindy Sprecher, Joseph Kuijper, Maria Dasovich, Francis Grant, Angela Hammond, Jane Gross
  • HUMAN TUMOR NECROSIS FACTOR RECEPTOR POLYNUCLEOTIDES
    Publication number: 20070178492
    Abstract: Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.
    Type: Application
    Filed: November 13, 2006
    Publication date: August 2, 2007
    Inventors: JANE GROSS, Wenfeng Xu, Randal Henne, Francis Grant
  • CYTOKINE ZALPHA11 LIGAND FUSION PROTEINS
    Publication number: 20070166794
    Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
    Type: Application
    Filed: October 23, 2006
    Publication date: July 19, 2007
    Inventors: Julia Novak, Scott Presnell, Cindy Sprecher, Donald Foster, Richard Holly, Jane Gross, Janet Johnston, Andrew Nelson, Stacey Dillon, Angela Hammond
  • CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS
    Publication number: 20070140964
    Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
    Type: Application
    Filed: October 26, 2006
    Publication date: June 21, 2007
    Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon
  • CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS
    Publication number: 20070140963
    Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
    Type: Application
    Filed: October 26, 2006
    Publication date: June 21, 2007
    Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon