Patents by Inventor Jane C. Schneider
Jane C. Schneider has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10689640Abstract: The present invention provides an array for rapidly identifying a host cell population capable of producing a heterologous recombinant protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous recombinant protein of interest in a periplasm compartment or may secrete the heterologous recombinant protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest including therapeutic proteins, hormones, growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: GrantFiled: December 19, 2016Date of Patent: June 23, 2020Assignee: Pfenex Inc.Inventors: Diane M. Retallack, Charles H. Squires, Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider, Charles D. Hershberger
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Patent number: 10612034Abstract: The present invention provides novel promoter and terminator sequences for use in heterologous gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a heterologous gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the heterologous gene; and methods for identifying promoters.Type: GrantFiled: June 1, 2012Date of Patent: April 7, 2020Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: Jane C. Schneider, Bo Liu, Rekha Seshadri
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Publication number: 20170183646Abstract: The present invention provides an array for rapidly identifying a host cell population capable of producing heterologous protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous protein of interest in a periplasm compartment, or may secrete the heterologous protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest, including therapeutic proteins, hormones, a growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: ApplicationFiled: December 19, 2016Publication date: June 29, 2017Inventors: Diane M. Retallack, Charles H. Squires, Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider, Charles D. Hershberger
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Patent number: 9580719Abstract: The present invention provides an array for rapidly identifying a host cell population capable of producing a heterologous protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous protein of interest in a periplasm compartment or may secrete the heterologous protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest including therapeutic proteins, hormones, growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: GrantFiled: October 30, 2009Date of Patent: February 28, 2017Assignee: PFENEX, INC.Inventors: Diane M. Retallack, Charles H. Squires, Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider, Charles D. Hershberger
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Patent number: 9394571Abstract: The present invention provides an array for rapidly identifying a host cell population capable of producing a heterologous protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous protein of interest in a periplasm compartment or may secrete the heterologous protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest including therapeutic proteins, hormones, growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: GrantFiled: April 25, 2008Date of Patent: July 19, 2016Assignee: PFENEX INC.Inventors: Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider, Charles D. Hershberger, Diane M. Retallack, Charles H. Squires
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Patent number: 9328336Abstract: The present invention provides diacylglycerol acyltransferase (DGAT) genes, including genes encoding localization peptides. The present invention also provides recombinant cells, such as algae, transformed with DGAT genes and methods of using such recombinant cells to produce triglyceride.Type: GrantFiled: October 16, 2012Date of Patent: May 3, 2016Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: Jane C Schneider, Eric Moellering, Erik Holtzapple, Soyan Lieberman, Gena Roy
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Patent number: 8883993Abstract: The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the gene; and methods for stably transforming eukaryotic algae such as Tetraselmis with transgenes.Type: GrantFiled: December 4, 2012Date of Patent: November 11, 2014Assignee: ExxonMobil Research and Engineering CompanyInventors: Jane C. Schneider, Soyan Lieberman, Bo Liu, Eric R. Moellering, John H. Verruto, Amanda Skaggs
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Publication number: 20140154806Abstract: The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the gene; and methods for stably transforming eukaryotic algae such as Tetraselmis with transgenes.Type: ApplicationFiled: December 4, 2012Publication date: June 5, 2014Applicant: ExxonMobil Research and Engineering CompanyInventors: Jane C. Schneider, Soyan Lieberman, Bo Liu, Eric R. Moellering, John H. Verruto, Amanda Skaggs
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Publication number: 20140106417Abstract: The present invention provides novel diacylglycerol acyltransferase (DGAT) genes, including novel genes encoding localization peptides. The present invention also provides recombinant cells, such as algae, transformed with DGAT genes and methods of using such recombinant cells to produce triglyceride.Type: ApplicationFiled: October 16, 2012Publication date: April 17, 2014Inventors: Jane C Schneider, Eric Moellering, Erik Holtzapple, Soyan Lieberman, Gena Roy
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Publication number: 20130323780Abstract: The present invention provides novel promoter and terminator sequences for use in heterologous gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a heterologous gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the heterologous gene; and methods for identifying promoters.Type: ApplicationFiled: June 1, 2012Publication date: December 5, 2013Applicant: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: JANE C. SCHNEIDER, BO LIU, REKHA SESHADRI
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Patent number: 8288127Abstract: The present invention provides an improved expression system for the production of recombinant polypeptides utilizing auxotrophic selectable markers. In addition, the present invention provides improved recombinant protein production in host cells through the improved regulation of expression.Type: GrantFiled: July 30, 2009Date of Patent: October 16, 2012Assignee: Pfenex, IncInventors: Jane C. Schneider, Lawrence C. Chew, Anne Kathryn Badgley, Thomas Martin Ramseier
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Patent number: 8034604Abstract: Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent concentration in food, industrial and oilfield applications. Methods for increasing the viscosity of xanthan include inducing particular key genes and increasing copy number of particular key genes.Type: GrantFiled: December 6, 2010Date of Patent: October 11, 2011Assignees: C.P. Kelco U.S., Inc., Fundacion Instituto LeloirInventors: Yamini Patel, Jane C. Schneider, Luis Ielpi, Maria Veronica Ielmini
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Patent number: 7985564Abstract: Improved methods and prokaryotic expression systems for producing recombinant proteins using Sec-system secretion signal peptides are described using Pseudomonas fluorescens Sec secretion systems. Specific novel Sec-system secretion signal peptides are described, as are fusion proteins and coding sequences for improved secretion of recombinant proteins and peptides.Type: GrantFiled: November 22, 2004Date of Patent: July 26, 2011Assignee: Pfenex, Inc.Inventors: Diane M. Retallack, Jane C. Schneider, Thomas Martin Ramseier
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Publication number: 20110111482Abstract: Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent concentration in food, industrial and oilfield applications. Methods for increasing the viscosity of xanthan include inducing particular key genes and increasing copy number of particular key genes.Type: ApplicationFiled: December 6, 2010Publication date: May 12, 2011Applicant: CP KELCO U.S., INC.Inventors: Yamini Patel, Jane C. Schneider, Luis Ielpi, Maria Veronica Ielmini
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Publication number: 20110020830Abstract: The present invention provides methods and compositions for the generation and identification of expression constructs that can be used to express sufficient levels of a polypeptide of interest. The compositions include a population of expression vectors, wherein members of the population have a type IIS restriction enzyme recognition site adjacent to a regulatory sequence, and wherein the regulatory element is distinct in at least two members of the population of expression vectors. In various embodiments, the expression vectors further comprise a polynucleotide sequence encoding a polypeptide of interest, wherein the polynucleotide encoding the polypeptide, the polynucleotide of the regulatory sequence, or both, are distinct in at least two members of the population. The compositions are useful for identifying a combination of coding sequences and/or regulatory elements useful for the heterologous expression of the polypeptide of interest.Type: ApplicationFiled: March 31, 2009Publication date: January 27, 2011Inventors: Jane C. Schneider, Charles H. Squires, Huizhu Liu
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Patent number: 7868168Abstract: Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent concentration in food, industrial and oilfield applications. Methods for increasing the viscosity of xanthan include inducing particular key genes and increasing copy number of particular key genes.Type: GrantFiled: September 16, 2008Date of Patent: January 11, 2011Assignees: C.P. Kelco U.S., Inc., Fundacion Instituto LeloirInventors: Yamini Patel, Jane C. Schneider, Luis Ielpi, Maria Veronica Ielmini
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Publication number: 20100137162Abstract: The present invention provides an array for rapidly identifying a host cell population capable of producing heterologous protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous protein of interest in a periplasm compartment, or may secrete the heterologous protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest, including therapeutic proteins, hormones, a growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like.Type: ApplicationFiled: October 30, 2009Publication date: June 3, 2010Applicant: Pfenex Biopharmaceuticals, Inc.Inventors: Diane M. Retallack, Charles H. Squires, Thomas M. Ramseier, Russell J. Coleman, Jane C. Schneider, Charies D. Hershberger
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Publication number: 20090325230Abstract: The present invention provides an improved expression system for the production of recombinant polypeptides utilizing auxotrophic selectable markers. In addition, the present invention provides improved recombinant protein production in host cells through the improved regulation of expression.Type: ApplicationFiled: July 30, 2009Publication date: December 31, 2009Applicant: DOW GLOBAL TECHNOLOGIES INC.Inventors: Jane C. Schneider, Lawrence C. Chew, Anne Kathryn Badgley, Thomas Martin Ramseier
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Patent number: 7618799Abstract: Compositions and methods for improving expression and/or secretion of protein or polypeptide of interest in a host cell are provided. Compositions comprising a coding sequence for a bacterial secretion signal peptide are provided. The coding sequences can be used in vector constructs or expression systems for transformation and expression of a protein or polypeptide of interest in a host cell. The compositions of the invention are useful for increasing accumulation of properly processed proteins in the periplasmic space of a host cell, or for increasing secretion of properly processed proteins from the host cell. In particular, isolated secretion signal peptide-encoding nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the nucleic acid molecules are encompassed.Type: GrantFiled: January 30, 2008Date of Patent: November 17, 2009Assignee: Dow Global Technologies IncInventors: Russell J. Coleman, Diane Retallack, Jane C. Schneider, Thomas M. Ramseier, Charles D. Hershberger, Stacey Lee, Sol M. Resnick
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Publication number: 20090093626Abstract: Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent concentration in food, industrial and oilfield applications. Methods for increasing the viscosity of xanthan include inducing particular key genes and increasing copy number of particular key genes.Type: ApplicationFiled: September 16, 2008Publication date: April 9, 2009Inventors: Yamini Patel, Jane C. Schneider, Luis Ielpi, Maria Veronica Ielmini