Patents by Inventor Jane E. Aubin

Jane E. Aubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ESTROGEN RECEPTOR-RELATED RECEPTOR GAMMA (ERR GAMMA) IN BONE AND CARTILAGE FORMATION AND METHODS AND COMPOSITIONS RELATING TO SAME
    Publication number: 20100285032
    Abstract: ERR? is expressed in bone and cartilage in vivo and osteoblastic and chondrocytic cells in vitro. ERR? is a transcriptional activator of an osteoblast-associated osteopontin (OPN) and chondrocyte-associated (Sox9) gene in osteoblasts and chondrocytes respectively. Knockdown of ERR? expression by antisense oligonucleotide strategies in osteoblastic cell cultures reduces alkaline phosphatase activity. Together these findings indicate that ERR? is expressed in and plays a functional role in bone and cartilage. The results also indicate that agonists and antagonists of ERR? may be useful as therapeutic agents in a wide variety of diseases affecting bones and joints.
    Type: Application
    Filed: June 9, 2008
    Publication date: November 11, 2010
    Inventors: Jane E. Aubin, Marco Cardelli, Ralph A. Zirngibl
  • Isolated mesenchymal cell population and method for isolating and using same
    Publication number: 20100150880
    Abstract: The present invention provides a novel isolated mesenchymal cell population of highly purified osteoprogenitors (HipOPs) that can be used in the formation of bone tissue and methods for isolating and using same.
    Type: Application
    Filed: November 4, 2009
    Publication date: June 17, 2010
    Applicant: The Governing Council of the University of Toronto
    Inventors: Jane E. Aubin, Shousaku Itoh
  • Estrogen Related Receptor, ERRalpha, A Regulator of Bone Formation
    Publication number: 20100119505
    Abstract: Methods and pharmaceutical compositions are provided for modulating bone formation in a mammal. Methods are also provided for screening compounds for their efficacy as modulators of bone formation.
    Type: Application
    Filed: August 10, 2009
    Publication date: May 13, 2010
    Inventors: Jane E. Aubin, Edith Bonnelye
  • Remedies for bone diseases
    Publication number: 20040254102
    Abstract: A therapeutic drugs for bone diseases containing as the active ingredient staniocalcin 1 which is found to have an effect of increasing bone mass. This drug for bone diseases is effective for bone diseases accompanied by anomalous osteogenesis or reduction in bone mass, such as osteoporosis, traumatic bone injuries, osteomalacia, rheumatic bone diseases, cancer-associated bone diseases, bone diseases associated with phosphorus metabolic error or calcium metabolic error, rachitis, and arthrosis deformans.
    Type: Application
    Filed: July 9, 2003
    Publication date: December 16, 2004
    Inventors: Yuji Yoshiko, Yoshio Koide, Akira Igarashi, Shoichi Takano, Norihiko Maeda, Jane E Aubin
  • Estrogen receptor-related receptor alpha (ERRalpha) and cartilage formation
    Publication number: 20020187953
    Abstract: Estrogen related receptor &agr; (ERR&agr;) is involved in control of cartilage formation in mammals. Increasing ERR&agr; activity causes stimulation of cartilage formation, providing a means of therapeutic intervention in diseases such as arthritis which involve cartilage destruction. Compounds may be screened for their potential as therapeutics by screening their effect on ERR&agr; cartilage promoting activity.
    Type: Application
    Filed: April 4, 2002
    Publication date: December 12, 2002
    Inventors: Jane E. Aubin, Edith Bonnelye