Patents by Inventor Jane Homan

Jane Homan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230019590
    Abstract: This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
    Type: Application
    Filed: November 11, 2021
    Publication date: January 19, 2023
    Inventors: Robert D. Bremel, Jane Homan
  • Patent number: 11434259
    Abstract: The present invention relates to vaccine compositions and therapeutic interventions for treating and preventing infections and diseases caused by flaviviruses, including Zika, dengue, and Usutu virus. It also relates to compositions and methods for diagnosis and differential diagnosis of flaviviruses and co-endemic pathogens.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: September 6, 2022
    Assignee: IOGENETICS, LLC
    Inventors: Robert D. Bremel, Jane Homan, Michael Imboden
  • Publication number: 20210375393
    Abstract: This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
    Type: Application
    Filed: July 6, 2020
    Publication date: December 2, 2021
    Inventors: Robert D. Bremel, Jane Homan
  • Publication number: 20210265008
    Abstract: The present invention provides methods and systems for identifying and classifying patterns comprising the T cell exposed motifs and the frequencies of such motifs in collections of proteins that make up the human proteome, immunoglobulinome, T cell receptor repertoire or microbiome, and other proteomes of environmental of microbial origin, or subsets thereof. It further provides graphical representations that facilitate comparisons of T cell exposed motif patterns between samples or between time points. The present invention also provides methods and systems for identifying and classifying patterns in repertoires of cells including receptor bearing cells and cells of tissue samples and detecting patterns of utility in diagnosis and monitoring of health and disease.
    Type: Application
    Filed: May 9, 2019
    Publication date: August 26, 2021
    Applicant: Iogenetics, LLC
    Inventors: Robert D. BREMEL, Jane HOMAN
  • Publication number: 20210023212
    Abstract: The present invention provides a means to prepare a product from domestic animal milk, blood or eggs which comprises an array of T-cell exposed motifs similar in identity, distribution and concentration to those found in human immunoglobulin variable regions and to prepare and apply the product as an immune modulating agent for administration either as a nutritional supplement or as a pharmaceutical product.
    Type: Application
    Filed: October 9, 2020
    Publication date: January 28, 2021
    Inventors: Robert D. Bremel, Jane Homan
  • Publication number: 20200402615
    Abstract: The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.
    Type: Application
    Filed: August 6, 2020
    Publication date: December 24, 2020
    Inventors: Robert D. Bremel, Jane Homan, Michael Imboden
  • Publication number: 20200390873
    Abstract: This invention provides a method for maximizing the immune response to mutated tumor specific proteins, either by means of stimulation of dendritic cells or T cells in vitro followed by administration of these cells to a patient, or by means of administration of a neoantigen vaccine in which de novo peptides, or their encoding nucleic acids, have been designed to ensure an appropriate level of binding affinity to a particular cancer patient's WIC alleles. This invention further provides for modulating the immune response in an immunopathology other than cancer.
    Type: Application
    Filed: June 11, 2020
    Publication date: December 17, 2020
    Inventors: Jane Homan, Robert D. Bremel
  • Patent number: 10799582
    Abstract: The present invention provides a means to prepare a product from domestic animal milk, blood or eggs which comprises an array of T-cell exposed motifs similar in identity, distribution and concentration to those found in human immunoglobulin variable regions and to prepare and apply the product as an immune modulating agent for administration either as a nutritional supplement or as a pharmaceutical product.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: October 13, 2020
    Assignee: IOGENETICS, LLC
    Inventors: Robert D. Bremel, Jane Homan
  • Patent number: 10755801
    Abstract: The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: August 25, 2020
    Assignee: IOGENETICS, LLC
    Inventors: Robert D. Bremel, Jane Homan, Michael Imboden
  • Patent number: 10706955
    Abstract: This invention relates to processes for identifying peptide and polypeptide ligands for a binding partner by using principal component analysis of amino acids to derive vectors describing amino acid subsets corresponding to peptides with known binding affinities and then using this information in a neural network modeling process to derive binding prediction equations. These binding prediction equations are then used in the analysis of subsets of amino acids from a target source to identify peptides or polypeptides ligands in the target source that have affinity for a binding partner.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: July 7, 2020
    Assignee: IOGENETICS, LLC
    Inventors: Robert D. Bremel, Jane Homan
  • Publication number: 20190070255
    Abstract: This invention pertains to the identification of antibody mediated epitope mimics and applications of the identification of said mimic peptides in the design of biotherapeutics and vaccines.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Inventors: Robert D. BREMEL, Jane HOMAN
  • Publication number: 20190031722
    Abstract: The present invention relates to vaccine compositions and therapeutic interventions for treating and preventing infections and diseases caused by flaviviruses, including Zika dengue, and Usutu virus. It also relates to compositions and methods for diagnosis and differential diagnosis of flaviviruses and co-endemic pathogens.
    Type: Application
    Filed: January 25, 2017
    Publication date: January 31, 2019
    Inventors: Robert D. Bremel, Jane Homan, Michael Imboden
  • Publication number: 20180221474
    Abstract: The present invention provides a means to prepare a product from domestic animal milk, blood or eggs which comprises an array of T-cell exposed motifs similar in identity, distribution and concentration to those found in human immunoglobulin variable regions and to prepare and apply the product as an immune modulating agent for administration either as a nutritional supplement or as a pharmaceutical product.
    Type: Application
    Filed: July 10, 2015
    Publication date: August 9, 2018
    Inventors: Robert D. Bremel, Jane Homan
  • Publication number: 20170161430
    Abstract: The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.
    Type: Application
    Filed: July 10, 2015
    Publication date: June 8, 2017
    Inventors: Robert D. Bremel, Jane Homan, Michael Imboden
  • Publication number: 20170039314
    Abstract: This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
    Type: Application
    Filed: September 13, 2012
    Publication date: February 9, 2017
    Applicant: IOGENETICS, LLC
    Inventors: Rober D. Bremel, Jane Homan
  • Publication number: 20160132631
    Abstract: This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
    Type: Application
    Filed: June 9, 2014
    Publication date: May 12, 2016
    Inventors: Robert D. Bremel, Jane Homan
  • Publication number: 20150284452
    Abstract: The present invention relates antimicrobial compositions, and in particular to antigen binding proteins comprising one or more domains that provide antimicrobial activity.
    Type: Application
    Filed: November 13, 2013
    Publication date: October 8, 2015
    Applicant: IOGENETICS, LLC
    Inventors: Robert Duane Bremel, Jane Homan, Michael Imboden, Brendan Keough
  • Patent number: 8703134
    Abstract: The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: April 22, 2014
    Assignees: ioGenetics, LLC, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Michael Imboden, Michael Riggs, Deborah A. Schaefer, Jane Homan, Robert D. Bremel
  • Publication number: 20130330335
    Abstract: This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
    Type: Application
    Filed: March 21, 2011
    Publication date: December 12, 2013
    Applicant: IOGENETICS, LLC
    Inventors: Robert D. Bremel, Jane Homan
  • Publication number: 20130230516
    Abstract: The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields.
    Type: Application
    Filed: February 6, 2013
    Publication date: September 5, 2013
    Applicants: Arizona Board of Regents on behalf of the University of Arizona, ioGenetics, LLC
    Inventors: Michael Imboden, Michael Riggs, Deborah A. Schaefer, Jane Homan, Robert D. Bremel