Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.

Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.

Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.

Abstract: Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.

Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.

Abstract: Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.

Abstract: Systems and methods directed to sampling endothelial cells within a pulmonary vasculature are provided. The system and method may include a cell sampling device having an elongated sheath extending from a proximal end to a distal end of the cell sampling device and defining an access lumen. An endovascular brush includes brush elements coupled to a shaft. The endovascular brush is dimensioned to be received in the access lumen of the elongated sheath. An actuation control is coupled to the shaft of the endovascular brush to axially translate the endovascular brush between a retracted position and an expanded position. Upon translation of the endovascular brush from the retracted position to the expanded position, the brush elements moves from within the access lumen to the pulmonary vasculature to obtain endothelial cells from a target artery of the pulmonary vasculature.

Abstract: The technology described herein is directed to agents that reduce the level of oxidant-modified ET-B Cys405, Cys403, or Cys402 and the identification and use of such agents for, e.g. to treat hypertension.

Abstract: The technology described herein is directed to agents that reduce the level of oxidant-modified ET-B Cys405, Cys403, or Cys402 and the identification and use of such agents for, e.g. to treat hypertension.

Abstract: We have surprisingly discovered that the enzyme glucose-6-phosphate dehydrogenase (G6PD) regulates angiogenesis. As a result of this discovery, the present invention provides modulation of angiogenesis in tissues where that angiogenesis depends upon the activity of G6PD.