Patents by Inventor Jane Leopold

Jane Leopold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and systems for generating fluid simulation models
    Patent number: 10748451
    Abstract: Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 18, 2020
    Assignees: DUKE UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Amanda Randles, Jane Leopold
  • METHODS AND SYSTEMS FOR GENERATING FLUID SIMULATION MODELS
    Publication number: 20180174490
    Abstract: Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.
    Type: Application
    Filed: December 15, 2017
    Publication date: June 21, 2018
    Inventors: Amanda Randles, Jane Leopold
  • Compositions and methods for treating hypertension
    Patent number: 9605047
    Abstract: The technology described herein is directed to agents that reduce the level of oxidant-modified ET-B Cys405, Cys403, or Cys402 and the identification and use of such agents for, e.g. to treat hypertension.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: March 28, 2017
    Assignee: The Brigham and Womens's Hospital, Inc.
    Inventors: Bradley Maron, Joseph Loscalzo, Jane Leopold
  • COMPOSITIONS AND METHODS FOR TREATING HYPERTENSION
    Publication number: 20150203563
    Abstract: The technology described herein is directed to agents that reduce the level of oxidant-modified ET-B Cys405, Cys403, or Cys402 and the identification and use of such agents for, e.g. to treat hypertension.
    Type: Application
    Filed: April 3, 2013
    Publication date: July 23, 2015
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Bradley Maron, Joseph Loscalzo, Jane Leopold
  • Method and composition for the modulation of angiogenesis
    Publication number: 20050032687
    Abstract: We have surprisingly discovered that the enzyme glucose-6-phosphate dehydrogenase (G6PD) regulates angiogenesis. As a result of this discovery, the present invention provides modulation of angiogenesis in tissues where that angiogenesis depends upon the activity of G6PD.
    Type: Application
    Filed: November 7, 2002
    Publication date: February 10, 2005
    Inventors: Joseph Loscalzo, Jane Leopold