Patents by Inventor Jane McGlade

Jane McGlade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF CBL AUTOINHIBITION AND RELATED METHODS
    Publication number: 20230212239
    Abstract: Described herein are agents that inhibit CBL autoinhibition, agents that activate CBL, SLAP and/or SLAP2 mimetics, and recombinant SLAP and/or SLAP2 or variants and/or fragments thereof that inhibit CBL autoinhibition. Also described are fusion proteins comprising these molecules as well as methods of inhibiting CBL autoinhibition and related uses thereof.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 6, 2023
    Inventors: C. Jane MCGLADE, Leanne WYBENGA-GROOT
  • Adapter gene
    Patent number: 7507801
    Abstract: The present invention relates to the identification and cloning of a novel gene, MARS (Modulator of Antigen Receptor Signaling), which is a putative tumor suppressor gene. The present invention also relates to the relation of the MARS gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the MARS gene, or lack the MARS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: March 24, 2009
    Assignee: The Hospital for Sick Children
    Inventors: Jane McGlade, Michael Loreto
  • Adapter gene
    Publication number: 20040171537
    Abstract: The present invention relates to the identification and cloning of a novel gene, MARS (Modulator of Antigen Receptor Signaling), which is a putative tumor suppressor gene. The present invention also relates to the relation of the MARS gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the MARS gene, or lack the MARS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
    Type: Application
    Filed: November 3, 2003
    Publication date: September 2, 2004
    Inventors: Jane McGlade, Michael Loreto
  • Novel Shc-binding protein
    Publication number: 20030170688
    Abstract: Novel Shc-binding protein, oligonucleotides encoding the same, methods of producing and use thereof are disclosed.
    Type: Application
    Filed: December 10, 2002
    Publication date: September 11, 2003
    Applicant: Amgen Canada, Inc.
    Inventors: Jane McGlade, Rosemary Schmandt
  • Polynucleotides encoding a novel SHC-binding protein
    Patent number: 6492138
    Abstract: Novel Shc-binding protein, oligonucleotides encoding the same, methods of producing and use thereof are disclosed.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: December 10, 2002
    Assignee: Amgen Canada Inc.
    Inventors: Jane McGlade, Rosemary Schmandt
  • Shc-binding protein
    Patent number: 6399747
    Abstract: Novel Shc-binding protein, oligonucleotides encoding the same, methods of producing and use thereof are disclosed.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: June 4, 2002
    Assignee: Amgen Canada, Inc.
    Inventors: Jane McGlade, Rosemary Schmandt