Patents by Inventor Jane Murphy
Jane Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140186918Abstract: A recombinant protein having luciferase activity and at least 60% similarity to a wild-type luciferase wherein in the sequence of the enzyme, the amino acid residue corresponding to residue 357 in Photinus pyralis luciferase is mutated as compared to the corresponding wild-type luciferase, such that the luciferase enzyme is able to emit light at a different wavelength as compared to the corresponding wild-type luciferase and/or has enhanced thermostability as compared to the corresponding wild-type luciferase. In general, the residue corresponding to 357 in Photinus pyralis luciferase is changed from an acidic amino acid to a non-acidic amino acid, and preferably an uncharged polar amino acid such as tyrosine. Mutant luciferases in accordance with the invention can produce a large (50 nm) wavelength shift in emitted light and have good thermostability. The resultant colour shift can be reversed by addition of coenzyme A. These properties make the mutant particularly useful in a variety of assays.Type: ApplicationFiled: February 14, 2014Publication date: July 3, 2014Applicant: PROMEGA CORPORATIONInventors: David James Squirrell, Melenie Jane Murphy, Rachel Louise Price, Peter John White, Tara Louise Willey
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Patent number: 8669087Abstract: A recombinant protein having luciferase activity and at least 60% similarity to a wild-type luciferase wherein in the sequence of the enzyme, the amino acid residue corresponding to residue 357 in Photinus pyralis luciferase is mutated as compared to the corresponding wild-type luciferase, such that the luciferase enzyme is able to emit light at a different wavelength as compared to the corresponding wild-type luciferase and/or has enhanced thermostability as compared to the corresponding wild-type luciferase. In general, the residue corresponding to 357 in Photinus pyralis luciferase is changed from an acidic amino acid to a non-acidic amino acid and preferably an uncharged polar amino acid such as tyrosine. Mutant luciferases in accordance with the invention can produce a large (50 nm) wavelength shift in emitted light and have good thermostability. The resultant colour shift can be reversed by addition of coenzyme A. These properties make the mutant particularly useful in a variety of assays.Type: GrantFiled: October 26, 2000Date of Patent: March 11, 2014Assignee: Promega CorporationInventors: David James Squirrell, Melenie Jane Murphy, Rachel Louise Price, Peter John White, Tara Louise Willey
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Patent number: 8187453Abstract: A method for the determination of the amount of cholesterol in a sample is provided. The method typically provides a breakdown of the HDL and LDL cholesterol contents of the sample.Type: GrantFiled: December 20, 2010Date of Patent: May 29, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Emma Naomi Kathleen Wallace-Davis, Lindy Jane Murphy, Andrew William Allan
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Publication number: 20110086373Abstract: A method for the determination of the amount of cholesterol in a sample is provided. The method typically provides a breakdown of the HDL and LDL cholesterol contents of the sample.Type: ApplicationFiled: December 20, 2010Publication date: April 14, 2011Inventors: Emma Naomi Kathleen WALLACE-DAVIS, Lindy Jane Murphy, Andrew William Allan
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Publication number: 20110031988Abstract: The invention relates to reducing signal distortions occurring when a potential is applied to an electrochemical cell. Electrochemical measurements are obtained in the presence of a specific chemical entity which is an aminoglycoside, an organic polyamine and/or a substance capable of raising the ionic strength of the sample.Type: ApplicationFiled: February 1, 2010Publication date: February 10, 2011Inventors: Lindy Jane Murphy, Hugh Allen Oliver Hill
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Publication number: 20100330596Abstract: Surfactants are provided which are particularly useful for carrying out cholesterol and triglyceride tests. These surfactants have particularly fast kinetics of response to cholesterol, cholesterol ester and triglyceride in all lipoprotein particles. Cholesterol or triglyceride sensors incorporating these surfactants therefore provide reliable measurements of the total cholesterol or triglyceride content of a sample in a short period of time. Also provided are a sensor comprising the subject surfactants for determining the amount of triglyceride and/or cholesterol in a sample, as well as methods for determining the amount of cholesterol and/or triglyceride in a sample, the method comprising: contacting the sample with a surfactant as defined above; and determining the amount of cholesterol and/or triglyceride present.Type: ApplicationFiled: December 11, 2009Publication date: December 30, 2010Inventor: Lindy Jane Murphy
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Patent number: 7754342Abstract: A corrosion resistant coating for gas turbine engine includes a glassy ceramic matrix wherein the glassy matrix is silica-based, and includes corrosion resistant particles selected from refractory particles and non-refractory MCrAlX particles, and combinations thereof. The corrosion resistant particles are substantially uniformly distributed within the matrix, and provide the coating with corrosion resistance. Importantly the coating of the present invention has a coefficient of thermal expansion (CTE) greater than that of alumina at engine operating temperatures. The CTE of the coating is sufficiently close to the substrate material such that the coating does not spall after frequent engine cycling at temperatures above 1200° F.Type: GrantFiled: December 19, 2005Date of Patent: July 13, 2010Assignee: General Electric CompanyInventors: Brian T. Hazel, Jane A. Murphy, Andrew J. Skoog, Bryan T. Bojanowski, Michael J. Weimer
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Publication number: 20090148872Abstract: According to the present invention there is provided a biosensor comprising a substrate containing a biochemical analyte, an enzyme system, a low molecular weight glycol ether and a detection means. The biochemical analyte is a low density lipoprotein. The enzyme system contains a cholesterol enzyme such as cholesterol esterase, cholesterol oxidase or cholesterol dehydrogenase.Type: ApplicationFiled: April 5, 2007Publication date: June 11, 2009Applicant: OXFORD BIOSENSORS LTD.Inventors: Lindy Jane Murphy, Herbert Frank Askew
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Publication number: 20080268421Abstract: A method for the determination of the amount of cholesterol in a sample is provided. The method typically provides a breakdown of the HDL and LDL cholesterol contents of the sample.Type: ApplicationFiled: December 21, 2006Publication date: October 30, 2008Inventors: Emma Naomi Kathleen Wallace-Davis, Lindy Jane Murphy, Andrew William Allan
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Publication number: 20070265955Abstract: An Internet trading network is operated by establishing supplier memberships of suppliers providing offerings to the trading network; establishing customer memberships of customers providing volume commitments; consolidating all volume commitments for a particular commodity or service when negotiating an offering with the supplier; managing memberships and their accounts.Type: ApplicationFiled: May 25, 2007Publication date: November 15, 2007Applicant: International Business Machines CorporationInventors: Theresa Broden, Glenn Codoy, Jane Murphy, Mark Musa, Sherry Wilson
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Publication number: 20070172585Abstract: An optical coating is applied to an article surface of an article by providing a deposition substrate other than the article surface, wherein the deposition substrate is made of a removable material. The optical coating is thereafter deposited onto the deposition substrate. The optical coating is thereafter transferred to the article surface using a transfer support, which may be the deposition substrate or may be a different piece. The method includes thereafter affixing the optical coating to the article surface, and thereafter removing the transfer support.Type: ApplicationFiled: January 16, 2007Publication date: July 26, 2007Applicant: GENERAL ELECTRIC COMPANYInventors: Daniel Ivkovich, Andrew Skoog, Jane Murphy, Thomas Rentz, William Stowell, Bryan Bojanowski
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Publication number: 20070141369Abstract: A corrosion resistant coating for gas turbine engine includes a glassy ceramic matrix wherein the glassy matrix is silica-based, and includes corrosion resistant particles selected from refractory particles and non-refractory MCrAlX particles, and combinations thereof. The corrosion resistant particles are substantially uniformly distributed within the matrix, and provide the coating with corrosion resistance. Importantly the coating of the present invention has a coefficient of thermal expansion (CTE) greater than that of alumina at engine operating temperatures. The CTE of the coating is sufficiently close to the substrate material such that the coating does not spall after frequent engine cycling at temperatures above 1200° F.Type: ApplicationFiled: December 19, 2005Publication date: June 21, 2007Applicant: General Electric CompanyInventors: Brian T. Hazel, Jane A. Murphy, Andrew J. Skoog
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Publication number: 20070141269Abstract: A coating and method for overcoating a TBC on a component used in a high-temperature environment, such as the combustor section of an industrial gas turbine. The coating defines the outermost surface of the component and is formed of at least two layers having different compositions. An inner layer of the coating contains alumina in a first silica-containing matrix material that is free of zinc titanate. An outer layer of the coating contains alumina, a glass material, and zinc titanate in a second silica-containing matrix material. The outer layer of the coating has a surface roughness of not greater than three micrometers Ra and forms the outermost surface of the component. The coating reduces the component temperature by reducing the convective and radiant heat transfer thereto.Type: ApplicationFiled: January 26, 2007Publication date: June 21, 2007Applicant: General Electric CompanyInventors: Wiliam Stowell, Daniel Ivkovich, Timothy Manning, Tara McGovern, Jane Murphy, Thomas Rentz, Mathew Roling, Raymond Rowe, Andrew Skoog
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Publication number: 20070104886Abstract: Electrostatic deposition of high performance powdered materials onto gas turbine surfaces. The process also includes post-deposition thermal staging of the deposited powder to provide a durable coating that will satisfy the demands of turbine engine operation. The process envisions application of organic-based powdered materials, glass/ceramic powdered materials and metal-based powdered materials and combinations thereof using electrostatic techniques to components exposed to low temperature operations, such as may be found in the front section of a gas turbine engine or to the exterior portions of an aircraft engine, and metal-containing glass ceramics, glass-ceramic materials, or materials that can be transformed into glass ceramic materials, when applied to components exposed to high temperature operations, such as may be found in the turbine and exhaust sections of a gas turbine engine or the flaps of an aircraft.Type: ApplicationFiled: November 10, 2005Publication date: May 10, 2007Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew Buczek, Andrew Skoog, Mark Rechtsteiner, Jane Murphy
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Publication number: 20060277084Abstract: A system for deploying to a client accounting installation a general procurement and accounts payable application specifically configured for the client by an enterprise includes a database server for (1) maintaining on a storage device a database of templates describing procedures for assessing, preparing, developing, deploying and supporting the application, and for (2) serving these templates to team members operating web-enabled terminals for coordinating, recording and tracking team activities with respect to the application while generating a description for adapting a front end server and an accounting system server to the requirements of the client.Type: ApplicationFiled: August 17, 2006Publication date: December 7, 2006Applicant: International Business Machines CorporationInventors: Ray Barnard, Philip Cirulli, Kerin Flannery, Carl Lanuti, Jane Murphy
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Publication number: 20060243368Abstract: A method for forming a ceramic layer on the surface of a turbine component. This method comprises the following steps: (a) providing a turbine component having a surface; (b) providing at least one ceramic tape overlaying the component surface; and (c) manually pressing the at least one ceramic tape against the component surface at a temperature of from about 150° to about 700° F. (from about 66° to about 371° C.) so as to cause the at least one ceramic tape to adhere to the component surface.Type: ApplicationFiled: April 28, 2005Publication date: November 2, 2006Inventors: William Stowell, Terry Kent, Thomas Rentz, Jane Murphy, Daniel Ivkovich, Andrew Skoog
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Publication number: 20060222777Abstract: A method for applying a plasma prayed coating using liquid injection is disclosed. The method includes providing a mixture of a liquid and solid particles. The solid particles are constituents of a thermal barrier coating. The mixture is injected into a plasma jet of a plasma spray device and the plasma jet is directed toward a substrate to deposit a gradient film formed from the constituents onto the substrate.Type: ApplicationFiled: April 5, 2005Publication date: October 5, 2006Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew Skoog, Jane Murphy, Thomas Tomlinson
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Publication number: 20060204666Abstract: A composition comprising a corrosion resistant metal particulate component comprising aluminum-containing metal particulates, wherein the aluminum-containing metal particulates have a phosphate and/or silica-containing insulating layer; and a glass-forming binder component. Also disclosed is a method comprising the following steps: (a) providing an article comprising a metal substrate; (b) imparting to the metal substrate an electrical charge; and (c) electrostatically depositing a coating composition on the electrically charged metal substrate, wherein the coating composition comprises aluminum-containing metal particulates having a phosphate and/or silica-containing insulating layer; and glass-forming binder component.Type: ApplicationFiled: March 10, 2005Publication date: September 14, 2006Inventors: Matthew Buczek, Andrew Skoog, Jane Murphy
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Publication number: 20060204665Abstract: A composition comprising a liquid mixture having: a corrosion resistant metal particulate component comprising aluminum-containing metal particulates, wherein the aluminum-containing metal particulates have a phosphate and/or silica-containing insulating layer; a glass-forming binder component; and a liquid carrier component. Also disclosed is a method comprising the following steps: (a) providing an article comprising a metal substrate; (b) imparting to the metal substrate an electrical charge; and (c) electrostatically applying a liquid coating composition to the electrically charged metal substrate, wherein the liquid coating composition comprises a liquid mixture having: a corrosion resistant metal particulate component comprising aluminum-containing metal particulates having a phosphate and/or silica-containing insulating layer; glass-forming binder component; and a liquid carrier component.Type: ApplicationFiled: March 10, 2005Publication date: September 14, 2006Inventors: Matthew Buczek, Andrew Skoog, Jane Murphy, Brian Hazel
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Publication number: 20060128548Abstract: A bond coat composition is provided for applying to the surface of a ceramic composite component between the composite substrate and the thermal barrier coat. The composition includes an alumina powder, a silica-yielding liquid, glass frits, and sufficient solvent to permit mixing of the components and forming a bond coat.Type: ApplicationFiled: February 10, 2004Publication date: June 15, 2006Applicant: General Electric CompanyInventors: Douglas Carper, Andrew Skoog, Jane Murphy