Patents by Inventor Jane P. Bearinger
Jane P. Bearinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12607589Abstract: The strip systems, methods, devices and associated kits disclosed herein are used to determine the presence and/or level a target analyte(s) in sample (e.g., a biological sample such as saliva or nasal swab) wherein the target analyte(s) may be a microorganism (e.g., a whole virus) or molecule (e.g., a viral antigen) associated with a healthy state, disease or injury or otherwise altered physiological condition. In certain embodiments, the systems, methods, devices and kits provide one or more improved properties relative to the lateral flow protein and other assays known in the art for the detection, including but not limited to, assay time, ease of use, risk of infection, accuracy, specificity, selectivity, limit of detection of the assay, quantitative detection and the effect of common interferents to the sensor output, cost, simplicity or a combination thereof. In certain embodiments, the systems, assays, methods and kids are multiplexed, i.e.Type: GrantFiled: January 13, 2022Date of Patent: April 21, 2026Assignee: Sorrento Therapeutics, Inc.Inventors: Mark William Grinstaff, Scott Edward Schaus, Jane P. Bearinger, Augustus Lang, Ziad Al-Shamsie, Dylann Ceriani
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Publication number: 20240309143Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: ApplicationFiled: May 22, 2024Publication date: September 19, 2024Inventors: Thomas S. Wilson, Jane P. Bearinger
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Publication number: 20240302317Abstract: The strip systems, methods, devices and associated kits disclosed herein are used to determine the presence and/or level a target analyte(s) in sample (e.g., a biological sample such as saliva or nasal swab) wherein the target analyte(s) may be a microorganism (e.g., a whole virus) or molecule (e.g., a viral antigen) associated with a healthy state, disease or injury or otherwise altered physiological condition. In certain embodiments, the systems, methods, devices and kits provide one or more improved properties relative to the lateral flow protein and other assays known in the art for the detection, including but not limited to, assay time, ease of use, risk of infection, accuracy, specificity, selectivity, limit of detection of the assay, quantitative detection and the effect of common interferents to the sensor output, cost, simplicity or a combination thereof. In certain embodiments, the systems, assays, methods and kids are multiplexed, i.e.Type: ApplicationFiled: January 13, 2022Publication date: September 12, 2024Inventors: Mark William Grinstaff, Scott Edward Schaus, Jane P. Bearinger, Augustus Lang, Ziad Al-Shamsie, Dylann Ceriani
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Publication number: 20240287240Abstract: This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.Type: ApplicationFiled: April 9, 2024Publication date: August 29, 2024Inventors: Thomas S. Wilson, Michael Keith Hearon, Jane P. Bearinger
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Patent number: 11993673Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling Chains by using monomers that are symmetrical and that have matching amine and hydroxyl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: GrantFiled: September 22, 2022Date of Patent: May 28, 2024Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Thomas S. Wilson, Jane P. Bearinger
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Patent number: 11958932Abstract: This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.Type: GrantFiled: December 16, 2022Date of Patent: April 16, 2024Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Thomas S. Wilson, Michael Keith Hearon, Jane P. Bearinger
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Patent number: 11933782Abstract: Detector systems are described, based on a primary binding compound and a secondary binding compound used in combination with a support to detect a target in a sample. The detection systems include a liquid medium hosting a first binding compound specific to a target, the first binding compound comprising a label; and a solid medium hosting a second binding compound specific to the target, the second binding compound being different from and non-competitive with respect to the first binding compound.Type: GrantFiled: August 15, 2017Date of Patent: March 19, 2024Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventor: Jane P. Bearinger
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Patent number: 11820852Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: GrantFiled: September 22, 2022Date of Patent: November 21, 2023Assignee: Lawrence Livermore National Security, LLCInventors: Thomas S. Wilson, Jane P. Bearinger
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Publication number: 20230141620Abstract: This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.Type: ApplicationFiled: December 16, 2022Publication date: May 11, 2023Inventors: Thomas S. Wilson, Michael Keith Hearon, Jane P. Bearinger
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Publication number: 20230030468Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: ApplicationFiled: September 22, 2022Publication date: February 2, 2023Inventors: Thomas S. Wilson, Jane P. Bearinger
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Publication number: 20230029649Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling Chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: ApplicationFiled: September 22, 2022Publication date: February 2, 2023Inventors: Thomas S. Wilson, Jane P. Bearinger
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Patent number: 11530291Abstract: This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.Type: GrantFiled: December 2, 2019Date of Patent: December 20, 2022Assignee: Lawrence Livermore National Security, LLCInventors: Thomas S. Wilson, Michael Keith Hearon, Jane P. Bearinger
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Patent number: 11453740Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: GrantFiled: December 23, 2019Date of Patent: September 27, 2022Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Thomas S. Wilson, Jane P. Bearinger
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Patent number: 11320432Abstract: Systems are described, based on a primary binding compound and a secondary binding compound used in combination with a support to detect a target in a sample. The systems includes at least one support structure, at least one small primary support portion containing at least one molecule covalently bound to a visual colloidal marker, a plurality of secondary support portions comprising secondary binding compounds that are covalently bound to the support portions and chemically active, at least one pH litmus indicator, at least one pH strip, a buffer for lateral flow on the porous membrane support that allows preservation and activity of binding compounds.Type: GrantFiled: August 15, 2017Date of Patent: May 3, 2022Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventor: Jane P. Bearinger
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Publication number: 20210070918Abstract: This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.Type: ApplicationFiled: December 2, 2019Publication date: March 11, 2021Inventors: Thomas S. Wilson, Michael Keith Hearon, Jane P. Bearinger
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Publication number: 20200131299Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Inventors: Thomas S. Wilson, Jane P. Bearinger
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Patent number: 10526437Abstract: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxyl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.Type: GrantFiled: August 14, 2017Date of Patent: January 7, 2020Assignee: Lawrence Livermore National Security, LLCInventors: Thomas S. Wilson, Jane P. Bearinger
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Patent number: 10494470Abstract: This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.Type: GrantFiled: December 21, 2016Date of Patent: December 3, 2019Assignee: Lawrence Livermore National Security, LLCInventors: Thomas S. Wilson, Michael Keith Hearon, Jane P. Bearinger
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Patent number: 10161390Abstract: A resistively heated shape memory polymer device is operated using resistive heating to heat the shape memory polymer device. The resistively heated shape memory polymer device is made by providing a wire that includes a resistive medium. The wire is coated with a first shape memory polymer. The wire is exposed and electrical leads are attached to the wire. In one embodiment the shape memory polymer device is in the form of a clot destruction device. In another embodiment the shape memory polymer device is in the form of a microvalve. In another embodiment the shape memory polymer device is in the form of a micropump. In yet another embodiment the shape memory polymer device is in the form of a thermostat or relay switch.Type: GrantFiled: March 14, 2013Date of Patent: December 25, 2018Assignee: Lawrence Livermore National Security, LLCInventors: John E. Marion, III, Jane P. Bearinger, Thomas S. Wilson, Ward Small, IV, Duncan J. Maitland
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Patent number: 10107270Abstract: A resistively heated shape memory polymer device is operated using resistive heating to heat the shape memory polymer device. The resistively heated shape memory polymer device is made by providing a wire that includes a resistive medium. The wire is coated with a first shape memory polymer. The wire is exposed and electrical leads are attached to the wire. In one embodiment the shape memory polymer device is in the form of a clot destruction device. In another embodiment the shape memory polymer device is in the form of a microvalve. In another embodiment the shape memory polymer device is in the form of a micropump. In yet another embodiment the shape memory polymer device is in the form of a thermostat or relay switch.Type: GrantFiled: February 25, 2016Date of Patent: October 23, 2018Assignee: Lawrence Livermore National Security, LLCInventors: John E. Marion, III, Jane P. Bearinger, Thomas S. Wilson, Ward Small, IV, Duncan J. Maitland