Abstract: Nodulisporic acids (NAs) comprise a group of indole diterpenes known for their potent insecticidal activities; however, biosynthesis of NAs by its natural producer, Hypoxylon pulicicidum (Nodulisporium sp.) is exceptionally difficult to achieve. The identification of genes responsible for NA production could enable biosynthetic pathway optimization to provide access to NAs for commercial applications. Obtaining useful quantities of NAs using published fermentations methods is challenging, making gene knockout studies an undesirable method to confirm gene function. Alternatively, heterologous gene expression of H. pulicicidum genes in a more robust host species like Penicillium paxilli provides a way to rapidly identify the function of genes that play a role in NA biosynthesis. In this work, we identified the function of four secondary-metabolic genes necessary for the biosynthesis of nodulisporic acid F (NAF) and reconstituted these genes in the genome of P.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: The present invention provides devices and system useful for transporting infants, minimizing vibrations, noise, and associated with transport. Devices of the invention include a head gear assembly, one or more body support rolls for elevating portions of the infant's body, and a mattress system with a removable insert. The invention further provides methods of use associated with such devices, including methods of stabilizing a position of an infant, reducing shock or vibration to an infant during transportation, reducing shock, vibration, or noise exposure to an infant during transportation, reducing shock or vibration while providing elevation to specific portions of an infant during transportation, and reducing the risk of intraventricular hemorrhage and/or persistent pulmonary hypertension to an infant during transportation.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: A head positioning aid includes at least one head positioning assistor and at least one securing member. Some head positioning aids include positioning members secured to a headwear member. The positioning members maintain an infant's head in midline. An optional cheek flap protects the skin on the face. An optional support member supports the neck and an open airway. Size adjustment members may also be used to secure and orient tubing for a nasal cannula.

Abstract: The present invention provides devices and system useful for transporting infants, minimizing vibrations, noise, and associated with transport. Devices of the invention include a head gear assembly, one or more body support rolls for elevating portions of the infants body, and a mattress system with a removable insert. The invention further provides methods of use associated with such devices, including methods of stabilizing a position of an infant, reducing shock or vibration to an infant during transportation, reducing shock, vibration, or noise exposure to an infant during transportation, reducing shock or vibration while providing elevation to specific portions of an infant during transportation, and reducing the risk of intraventricular hemorrhage and/or persistent pulmonary hypertension to an infant during transportation.

Abstract: A head immobilization aid includes immobilization members, a rear panel, at least one strap, and at least one flap. The immobilization members maintain a patient's head in a desired position. The strap secures the head immobilization aid to a patient's head and the flap secures the immobilization members in a desired position. The head immobilization aid may be used in conjunction with an attachment device to secure and orient tubing for continuous positive airway pressure (CPAP) and nasal cannulas to the head immobilization aid.

Abstract: A head positioning aid (100) includes positioning members (102) secured to a headwear member (110). The positioning members maintain an infant's head in midline. At least one strap (120) on the headwear member secures the head positioning aid to an infant's head. Optional securing devices (200) secure and orient tubing (172, 174) for CPAP and nasal cannulas to the headwear member.

Abstract: A head positioning aid includes at least one head positioning assistor and at least one securing member. Some head positioning aids include positioning members secured to a headwear member. The positioning members maintain an infant's head in midline. An optional cheek flap protects the skin on the face. An optional support member supports the neck and an open airway. Size adjustment members may also be used to secure and orient tubing for a nasal cannula.

Abstract: A head-positioning aid for treating or preventing plagiocephaly and torticollis is formed of a soft, compliant beanie-style cap. A soft and pliable deflector is attached to the beanie cap and extends downward from near the apex to near the lower edge of the cap. The cap is applied on an infant's head in an orientation to place the deflector at any required position about the circumference of the head. The cap and deflector are united by themed indicia designed to bring family acceptance of the cap to promote acceptance and thereby support long term usage, as may be required.

Abstract: A head-positioning aid for treating or preventing plagiocephaly and torticollis is formed of a soft, compliant beanie-style cap. A soft and pliable deflector is attached to the beanie cap and extends downward from near the apex to near the lower edge of the cap. The cap is applied on an infant's head in an orientation to place the deflector at any required position about the circumference of the head. The cap and deflector are united by themed indicia designed to bring family acceptance of the cap to promote acceptance and thereby support long term usage, as may be required.